Thue W. Schwartz

Thue W. Schwartz

Professor

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85

  • Nutrient and Metabolite Sensing

    Blegdamsvej 3B, Building: 07-6-85

    2200 København N

    Denmark


  1. Published

    Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor. / Rosenkilde, Mette Marie; Schwartz, Thue W.

    In: Molecular Pharmacology, No. 57, no. 3, 2000, p. 602-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. / Simmons, G.; Clapham, P.R.; Picard, L.; Offord, R.E.; Rosenkilde, Mette Marie; Schwartz, Thue W.; Buser, R.; Weels, T.N.C.; Proudfoot, A.

    In: Kexue (Shanghai), No. 276, 1997, p. 276-279.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Preassociation between the 5-HT7 serotonin receptor and G protein Gs : molecular determinants and association with low potency activation of adenylyl cyclase. / Ulsund, Andrea Hembre; Dahl, Marie; Frimurer, Thomas M.; Manfra, Ornella; Schwartz, Thue W.; Levy, Finn Olav; Andressen, Kjetil Wessel.

    In: FASEB Journal, Vol. 33, No. 3, 2019, p. 3870-3886.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Principles of Agonism - Undressing Efficacy. / Schwartz, Thue W.; Ijzermann, A.P.

    In: TIPS - Trends in Pharmacological Sciences, No. 19, no. 11, 1998, p. 433-436.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Processing of pro-CGRP in a rat medullary thyroid carcinoma cell line transfected with protease inhibitors. / Johansen, Teit Eliot; Schifter, S; Vogel, Charlotte Katrine; Tolstoy, Susanne; Schwartz, Thue W.

    In: Molecular and Cellular Endocrinology, Vol. 82, No. 1, 1991, p. 51-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms. / Egerod, Kristoffer L.; Petersen, Natalia; Timshel, Pascal N.; Rekling, Jens C.; Wang, Yibing; Liu, Qinghua; Schwartz, Thue W.; Gautron, Laurent.

    In: Molecular Metabolism, Vol. 12, 2018, p. 62-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91. / Trauelsen, Mette; Rexen Ulven, Elisabeth; Hjorth, Siv A; Brvar, Matjaz; Monaco, Claudia; Frimurer, Thomas M; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 6, No. 12, 12.2017, p. 1585-1596.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Regional distribution of putative NPY Y*U1 receptors and neurons expressing Y*U1 mRNA in forebrain areas of the rat central nervous system. / Larsen, Philip J.; Sheikh, Søren P.; Jakobsen, Cherine R.; Schwartz, Thue W.; Mikkelsen, J.D.

    In: European Journal of Neuroscience, No. Vol 5, 1993, p. 1622-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Release of PYY from pig intestinal mucosa; luminal and neural regulation. / Sheikh, S P; Holst, J J; Orskov, C; Ekman, R; Schwartz, T W.

    In: Regulatory Peptides, Vol. 26, No. 3, 12.1989, p. 253-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Research Resource : A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells. / Engelstoft, Maja S; Lund, Mari L; Grunddal, Kaare V; Egerod, Kristoffer L; Osborne-Lawrence, Sherri; Poulsen, Steen Seier; Zigman, Jeffrey M; Schwartz, Thue W.

    In: Molecular endocrinology (Baltimore, Md.), Vol. 29, No. 11, 11.2015, p. 1658-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. / Li, Yingrui; Vinckenbosch, Nicolas; Tian, Geng; Huerta-Sanchez, Emilia; Jiang, Tao; Jiang, Hui; Albrechtsen, Anders; Andersen, Gitte; Cao, Hongzhi; Korneliussen, Thorfinn Sand; Grarup, Niels; Guo, Yiran; Hellman, Ines; Jin, Xin; Li, Qibin; Liu, Jiangtao; Liu, Xiao; Sparsø, Thomas; Tang, Meifang; Wu, Honglong; Wu, Renhua; Yu, Chang; Zheng, Hancheng; Astrup, Arne; Bolund, Lars; Holmkvist, Johan; Jørgensen, Torben; Kristiansen, Karsten; Schmitz, Ole; Schwartz, Thue W; Zhang, Xiuqing; Li, Ruiqiang; Yang, Huanming; Wang, Jian; Hansen, Torben; Pedersen, Oluf; Nielsen, Rasmus; Wang, Jun.

    In: Nature Genetics, Vol. 42, No. 11, 2010, p. 969-72.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Reversible switching of ultrastrong light-molecule coupling. / Schwartz, T; Hutchison, J A; Genet, C; Ebbesen, T W.

    In: Physical Review - Index, Vol. 106, 13.05.2011, p. 196405.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production. / Piccand, Julie; Vagne, Constance; Blot, Florence; Meunier, Aline; Beucher, Anthony; Strasser, Perrine; Lund, Mari L.; Ghimire, Sabitri; Nivlet, Laure; Lapp, Celine; Petersen, Natalia; Engelstoft, Maja S.; Thibault-Carpentier, Christelle; Keime, Celine; Correa, Sara Jimenez; Schreiber, Valerie; Molina, Nacho; Schwartz, Thue W.; De Arcangelis, Adele; Gradwohl, Gerard.

    In: Molecular Metabolism, Vol. 29, 2019, p. 24-39.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74. / Rosenkilde, M M; Kledal, T N; Holst, Peter Johannes; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 275, No. 34, 2000, p. 26309-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28. / Kledal, Thomas N.; Rosenkilde, Mette Marie; Schwartz, Thue W.

    In: FEBS Letters, No. 441, 1998, p. 209-214.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. / Engelstoft, Maja S; Park, Won-Mee; Sakata, Ichiro; Kristensen, Line V; Husted, Anna Sofie; Osborne-Lawrence, Sherri; Piper, Paul K; Walker, Angela K; Pedersen, Maria H; Nøhr, Mark K; Pan, Jie; Sinz, Christopher J; Carrington, Paul E; Akiyama, Taro E; Jones, Robert M; Tang, Cong; Ahmed, Kashan; Offermanns, Stefan; Egerod, Kristoffer Lihme; Zigman, Jeffrey M; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 2, No. 4, 11.2013, p. 376-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74. / McLean, Katherine A; Holst, Peter J; Martini, Lene; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Virology, Vol. 325, No. 2, 2004, p. 241-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Single-chain vascular endothelial growth factor variant with antagonist activity. / Boesen, Thomas P; Soni, Bobby; Schwartz, Thue W; Halkier, Torben.

    In: Journal of Biological Chemistry, Vol. 277, No. 43, 2002, p. 40335-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Split-receptors in the tachykinin NK-1 system - mutational analysis of intracellular loop 3. / Nielsen, Søren M.; Elling, Christian E.; Schwartz, Thue W.

    In: European Journal of Biochemistry, No. 251, 1998, p. 217-226.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor. / Holst, Birgitte; Jensen, Sannah Zoffmann; Elling, Christian E.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Molecular Pharmacology, No. 53, no. 1, 1998, p. 166-175.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. / Engelstoft, Maja Storm; Norn, C; Pedersen, Maria Hauge; Holliday, N D; Elster, L; Lehmann, J; Jones, R M; Frimurer, T M; Schwartz, T W.

    In: British Journal of Pharmacology, Vol. 171, No. 24, 12.2014, p. 5774-89.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structural biology: A moving story of receptors. / Schwartz, Thue W; Hubbell, Wayne L.

    In: Nature, Vol. 455, No. 7212, 2008, p. 473-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Structural biology: Full monty of family B GPCRs. / Schwartz, Thue W; Frimurer, Thomas M.

    In: Nature Chemical Biology, Vol. 13, No. 8, 2017, p. 819-821.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1. / Rexen Ulven, Elisabeth; Trauelsen, Mette; Brvar, Matjaz; Lückmann, Michael; Bielefeldt, Line Ø; Jensen, Lisa K I; Schwartz, Thue W; Frimurer, Thomas M.

    In: Scientific Reports, Vol. 8, No. 1, 10010, 2018, p. 1-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Structure-based discovery of novel US28 small molecule ligands with different modes of action. / Lückmann, Michael; Amarandi, Roxana-Maria; Papargyri, Natalia; Jakobsen, Mette H; Christiansen, Elisabeth; Jensen, Lars Juhl; Pui, Aurel; Schwartz, Thue W.; Rosenkilde, Mette Marie; Frimurer, Thomas Michael.

    In: Chemical Biology & Drug Design, Vol. 89, No. 3, 2017, p. 289–296.

    Research output: Contribution to journalJournal articleResearchpeer-review

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