Thue W. Schwartz

Thue W. Schwartz

Professor

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85

    Mobile: +45 22 62 22 25

  • Nutrient and Metabolite Sensing

    Blegdamsvej 3B, Building: 07-6-85

    2200 København N

    Denmark

ORCID: 0000-0002-0261-6904

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  1. Published

    Molecular structure and function of 7TM/G-protein coupled receptors. / Schwartz, Thue W.; Holst, Birgitte.

    Textbook of receptor Pharmacology. 2002. p. 65-84.

    Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

  2. Published

    Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities. / Waldhoer, Maria; Kledal, Thomas N; Farrell, Helen; Schwartz, Thue W.

    In: Journal of Virology, Vol. 76, No. 16, 2002, p. 8161-8.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Mutation of Asp (171) and Asp (262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. / Hatse, S.; Princen, K.; Gerlach, Lars-Ole; Bridger, G.; Henson, G.; De Clercq, E.; Schwartz, Thue W.; Schols, D.

    In: Molecular Pharmacology, No. 60 (1), 2001, p. 164-173.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. / Hatse, S; Princen, K; Gerlach, L O; Bridger, G; Henson, G; De Clercq, E; Schwartz, T W; Schols, D.

    In: Molecular Pharmacology, Vol. 60, No. 1, 2001, p. 164-73.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening. / Norn, Christoffer; Pedersen, Maria Hauge; Engelstoft, Maja S.; Kim, Sun Hee; Lehmann, Juerg; Jones, Robert M.; Schwartz, Thue W.; Frimurer, Thomas M.

    In: Structure, Vol. 23, No. 12, 2015, p. 2377-2386.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptor. / Costa-Neto, C.M.; Miyakawa, A.A.; Oliveira, L.; Hjorth, Siv A.; Schwartz, Thue W.; Paiva, A.C.

    In: British Journal of Pharmacology, No. 130, no. 6, 2000, p. 1263-8.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors. / Jones, R.M.; Hjorth, Siv A.; Schwartz, Thue W.; Portoghese, P.S.

    In: Journal of Medicinal Chemistry, No. 41, 1998, p. 4911-4914.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry. / Hatse, Sigrid; Princen, Katrien; Vermeire, Kurt; Gerlach, Lars-Ole; Rosenkilde, Mette M; Schwartz, Thue W; Bridger, Gary; De Clercq, Erik; Schols, Dominique.

    In: FEBS Letters, Vol. 546, No. 2-3, 2003, p. 300-6.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype. / Martini, Lene; Hastrup, Hanne; Holst, Birgitte; Fraile-Ramos, Alberto; Marsh, Mark; Schwartz, Thue W.

    In: Molecular Pharmacology, Vol. 62, No. 1, 2002, p. 30-7.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor. / Rosenkilde, M M; Lucibello, M; Holst, B; Schwartz, T W.

    In: FEBS Letters, Vol. 439, No. 1-2, 1998, p. 35-40.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism. / Grunddal, Kaare Villum; Ratner, Cecilia F; Svendsen, Berit; Sommer, Felix; Engelstoft, Maja S; Madsen, Andreas N; Pedersen, Jens; Nøhr, Mark K; Egerod, Kristoffer L; Nawrocki, Andrea R; Kowalski, Timothy; Howard, Andrew D; Poulsen, Steen Seier; Offermanns, Stefan; Bäckhed, Gert Fredrik; Holst, Jens J; Holst, Birgitte; Schwartz, Thue W.

    In: Endocrinology, Vol. 157, No. 1, en20151600, 01.2016, p. 176-94.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. / Holst, Birgitte; Brandt, Erik; Bach, Anders; Heding, Anders; Schwartz, Thue W.

    In: Molecular Endocrinology, Vol. 19, No. 9, 2005, p. 2400-11.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor. / Heding, A; Elling, C E; Schwartz, T W.

    In: Journal of Receptors and Signal Transduction, Vol. 22, No. 1-4, 2002, p. 241-52.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors. / Engelstoft, M S; Schwartz, T W.

    In: Trends in Endocrinology and Metabolism, Vol. 27, No. 9, 09.2016, p. 665-675.

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor. / Hassing, H A; Engelstoft, M S; Sichlau, R M; Madsen, A N; Rehfeld, J F; Pedersen, J; Jones, R M; Holst, J J; Schwartz, T W; Rosenkilde, M M; Hansen, Harald S.

    In: BioFactors, Vol. 42, No. 6, 2016, p. 665-673.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. / Holst, Birgitte; Frimurer, Thomas M; Mokrosinski, Jacek; Halkjaer, Tine; Cullberg, Karina B; Underwood, Christina R; Schwartz, Thue W.

    In: Molecular Pharmacology, Vol. 75, No. 1, 2008, p. 44-59.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s). / Jorgensen, Rasmus; Kubale, Valentina; Vrecl, Milka; Schwartz, Thue W; Elling, Christian E.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 322, No. 1, 2007, p. 148-54.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95 : quantitative characterization of interactions. / Møller, Thor C; Wirth, Volker F; Roberts, Nina Ingerslev; Bender, Julia; Bach, Anders; Jacky, Birgitte P S; Strømgaard, Kristian; Deussing, Jan M; Schwartz, Thue W; Martinez, Karen L.

    In: PLOS ONE, Vol. 8, No. 5, e63352, 2013.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. E-pub ahead of print

    Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice. / Jepsen, Sara L.; Grunddal, Kaare V.; Wewer Albrechtsen, Nicolai J; Engelstoft, Maja S; Gabe, Maria B N; Jensen, Elisa P; Ørskov, Cathrine; Poulsen, Steen S; Rosenkilde, Mette M; Pedersen, Jens; Gribble, Fiona M; Reimann, Frank; Deacon, Carolyn F; Schwartz, Thue W; Christ, Andreas D; Martin, Rainer E; Holst, Jens J.

    In: A J P: Endocrinology and Metabolism (Online), 10.09.2019.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor. / Holst, B; Elling, C E; Schwartz, T W.

    In: Molecular Pharmacology, Vol. 58, No. 2, 2000, p. 263-70.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation. / Valentin-Hansen, Louise; Holst, Birgitte; Frimurer, Thomas M; Schwartz, Thue W; Hansen, Louise Valentin.

    In: Journal of Biological Chemistry, Vol. 287, No. 52, 21.12.2012, p. 43516-43526.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Phorbol esters and SDF-1 induce rapid endocytosis and down-modulation of the chemokine receptor CXCR4. / Signoret, N.; Oldridge, J.; Pelchen-Matthews, A.; Klasse, P.J.; Tran, T.; Brass, L.F.; Rosenkilde, Mette Marie; Schwartz, Thue W.; Luther, Michael A.; Wells, T.N.C.; Hoxie, J.A.; March, Mark.

    In: Journal of Cell Biology, No. 139, no. 3, 1997, p. 651-664.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Plagiarism of the host immune system - lessons about chemokine immunology from viruses. / Wells, T.N.C.; Schwartz, Thue W.

    In: Current Opinion in Biotechnology, No. 8, no. 6, 1997, p. 741-748.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. / Jensen, Pia C; Thiele, Stefanie; Ulven, Trond; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Journal of Biological Chemistry, Vol. 283, No. 34, 17.06.2008, p. 23121-23128.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. / Jensen, Pia C; Thiele, Stefanie; Ulven, Trond; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Journal of Biological Chemistry, Vol. 283, No. 34, 2008, p. 23121-8.

    Research output: Contribution to journal › Journal article › Research › peer-review

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