Thue W. Schwartz

Thue W. Schwartz

Professor

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85

  • Nutrient and Metabolite Sensing

    Blegdamsvej 3B, Building: 07-6-85

    2200 København N

    Denmark


  1. Published

    MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. / Lüttichau, H R; Gerstoft, J; Schwartz, T W.

    In: Journal of Leukocyte Biology, Vol. 70, No. 2, 2001, p. 277-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. / Andersson, Ehm A; Holst, Birgitte; Sparsø, Thomas; Grarup, Niels; Banasik, Karina; Holmkvist, Johan; Jørgensen, Torben; Borch-Johnsen, Knut; Egerod, Kristoffer L; Lauritzen, Torsten; Sørensen, Thorkild I A; Bonnefond, Amélie; Meyre, David; Froguel, Philippe; Schwartz, Thue W; Pedersen, Oluf; Hansen, Torben.

    In: Diabetes, Vol. 59, No. 6, 2010, p. 1539-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid. / Valentin-Hansen, Louise; Park, Minyoung; Huber, Thomas; Grunbeck, Amy; Naganathan, Saranga; Schwartz, Thue W.; Sakmar, Thomas P.

    In: The Journal of Biological Chemistry, Vol. 289, No. 26, 27.06.2014, p. 18045-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor. / Gerlach, Lars Ole; Jakobsen, Janus S; Jensen, Kasper P; Rosenkilde, Mette R; Skerlj, Renato T; Ryde, Ulf; Bridger, Gary J; Schwartz, Thue W.

    In: Biochemistry, Vol. 42, No. 3, 2003, p. 710-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. / Elling, Christian E; Frimurer, Thomas M; Gerlach, Lars-Ole; Jorgensen, Rasmus; Holst, Birgitte; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 281, No. 25, 2006, p. 17337-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. / Holst, Birgitte; Elling, Christian E; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 277, No. 49, 2002, p. 47662-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors. / Elling, Christian E.; Thirstrup, Kenneth; Nielsen, Søren M.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Annals of the New York Academy of Sciences, No. 814, 1997, p. 142-151.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced obesity. / Arora, Tulika; Rudenko, Olga; Egerod, Kristoffer Lihme; Husted, Anna Sofie; Kovatcheva-Datchary, Petia; Akrami, Rozita; Kristensen, Mette; Schwartz, Thue W.; Backhed, Fredrik.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 316, No. 3, 03.2019, p. E453-E463.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Microbial regulation of the L cell transcriptome. / Arora, Tulika; Akrami, Rozita; Pais, Ramona; Bergqvist, Linda; Johansson, Bengt R; Schwartz, Thue W.; Reimann, Frank; Gribble, Fiona M; Bäckhed, Fredrik.

    In: Scientific Reports, Vol. 8, 1207, 2018, p. 1-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions. / Frimurer, Thomas M.; Mende, Franziska; Graae, Anne-Sofie; Engelstoft, Maja S.; Egerod, Kristoffer L.; Nygaard, Rie; Gerlach, Lars-Ole; Hansen, Jakob Bondo; Schwartz, Thue W.; Holst, Birgitte.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 3, 2017, p. 886-898.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor. / Hatse, Sigrid; Huskens, Dana; Princen, Katrien; Vermeire, Kurt; Bridger, Gary J; De Clercq, Erik; Rosenkilde, Mette M; Schwartz, Thue W; Schols, Dominique.

    In: Journal of Virology, Vol. 81, No. 7, 2007, p. 3632-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop. / Mokrosinski, Jacek; Frimurer, Thomas M; Sivertsen, Bjoern; Schwartz, Thue W; Holst, Birgitte.

    In: Journal of Biological Chemistry, Vol. 287, 09.2012, p. 33488-33502.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males. / Riis, Simon; Christensen, Britt; Nellemann, Birgitte; Moller, Andreas Ruch; Husted, Anna Sofie; Pedersen, Steen B.; Schwartz, Thue W.; Jorgensen, Jens Otto Lunde; Jessen, Niels.

    In: Journal of Applied Physiology, Vol. 126, No. 3, 2019, p. 569-577.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII. / Gbahou, F; Holst, B; Schwartz, T W.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 333, No. 1, 2010, p. 51-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine. / Mizoue, L S; Sullivan, S K; King, D S; Kledal, T N; Schwartz, T W; Bacon, K B; Handel, T M.

    In: Journal of Biological Chemistry, Vol. 276, No. 36, 2001, p. 33906-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1. / Lückmann, Michael; Trauelsen, Mette; Bentsen, Marie A; Nissen, Tinne A D; Martins, Joao; Fallah, Zohreh; Nygaard, Mads M; Papaleo, Elena; Lindorff-Larsen, Kresten; Schwartz, Thue W; Frimurer, Thomas M.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 14, 02.04.2019, p. 7123-7128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. / Jensen, Pia C; Nygaard, Rie; Thiele, Stefanie; Elder, Amy; Zhu, Guoming; Kolbeck, Roland; Ghosh, Shomir; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Molecular Pharmacology, Vol. 72, No. 2, 2007, p. 327-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. / Gerlach, Lars-Ole; Skerlj, R.T.; Bridger, G.J.; Schwartz, Thue W.

    In: Journal of Biological Chemistry, No. 276 (17), 2001, p. 14153-14160.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Molecular mechanism of 7TM receptor activation--a global toggle switch model. / Schwartz, Thue W; Frimurer, Thomas M; Holst, Birgitte; Rosenkilde, Mette M; Elling, Christian E.

    In: Annual Review of Pharmacology and Toxicology, Vol. 46, 2006, p. 481-519.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. / Rosenkilde, Mette M; Gerlach, Lars-Ole; Jakobsen, Janus S; Skerlj, Renato T; Bridger, Gary J; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 279, No. 4, 2004, p. 3033-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. / Rosenkilde, Mette Marie; Gerlach, Lars-Ole; Jakobsen, J.S.; Skerlj, R.T.; Bridger, Gary; Schwartz, Thue W.

    In: Journal of Biological Chemistry, No. VOl. 279, no. 4, 2004, p. 3033-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. / Storjohann, Laura; Holst, Birgitte; Schwartz, Thue W.

    In: FEBS Letters, Vol. 582, No. 17, 2008, p. 2583-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. / Rosenkilde, Mette M; Gerlach, Lars-Ole; Hatse, Sigrid; Skerlj, Renato T; Schols, Dominique; Bridger, Gary J; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 282, No. 37, 2007, p. 27354-65.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe. / Holst, Birgitte; Schwartz, Thue W.

    In: Annals of the New York Academy of Sciences, Vol. 994, 2003, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity. / Rosenkilde, Mette M; Benned-Jensen, Tau; Holst, Peter J; Kledal, Thomas N; Lüttichau, Hans R; Larsen, Jørgen K; Christensen, Jan P; Schwartz, Thue W; Andersen, Helene.

    In: Journal of Biological Chemistry, Vol. 281, No. 19, 2006, p. 13199-208.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 11601