Thue W. Schwartz

Thue W. Schwartz

Professor

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85

  • Nutrient and Metabolite Sensing

    Blegdamsvej 3B, Building: 07-6-85

    2200 København N

    Denmark


  1. Published

    7TM receptorer - fra lugtesans og nye hormoner til HIV-infektion. / Schwartz, Thue W.

    In: Ugeskrift for læger, No. 159, 1997, p. 1239-1245.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin. / Egerod, Kristoffer L; Engelstoft, Maja S; Grunddal, Kaare V; Nøhr, Mark K; Secher, Anna; Sakata, Ichiro; Pedersen, Jens; Windeløv, Johanne A; Füchtbauer, Ernst-Martin; Olsen, Jørgen; Sundler, Frank; Christensen, Jan P; Wierup, Nils; Olsen, Jesper V; Holst, Jens J; Zigman, Jeffrey M; Poulsen, Steen S; Schwartz, Thue W.

    In: Endocrinology, Vol. 153, No. 12, 01.12.2012, p. 5782-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus. / Kledal, Thomas N.; Rosenkilde, Mette Marie; Coulin, F.; Simmons, G.; Johnsen, A.H.; Alouani, S.; Schwartz, Thue W.; Poucer, C.A.; Lüttichau, H.R.; Gerstoft, J.; Clapham, P.R.; Clark-Lewis, I.; Wells, T.N.C.

    In: Kexue (Shanghai), No. 277, 1997, p. 1656-1659.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. / Holst, Birgitte; Nygaard, Rie; Hansen, Louise Valentin; Bach, Anders; Engelstoft, Maja S; Petersen, Pia S; Frimurer, Thomas M; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 285, No. 6, 2010, p. 3973-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A gut feeling for obesity: 7TM sensors on enteroendocrine cells. / Engelstoft, Maja Storm; Egerod, Kristoffer L; Holst, Birgitte; Schwartz, Thue W.

    In: Cell Metabolism, Vol. 8, No. 6, 2008, p. 447-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum. / Lüttichau, Hans Rudolf; J., Stine; Boesen, Thomas Peter; Johnsen, A.H.; Chantry, D.; Gerstoft, J.; Schwartz, Thue W.

    In: Journal of Experimental Medicine, No. 191, no. 1, 2000, p. 171-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6. / Lüttichau, Hans R; Clark-Lewis, Ian; Jensen, Peter Østrup; Moser, Claus; Gerstoft, Jan; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 278, No. Vol. 278 (13), 2003, p. 10928-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). / Heydorn, Arne; Søndergaard, Birgitte P; Ersbøll, Bjarne; Holst, Birgitte; Nielsen, Finn Cilius; Haft, Carol Renfrew; Whistler, Jennifer; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 279, No. 52, 2004, p. 54291-303.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39. / Storjohann, Laura; Holst, Birgitte; Schwartz, Thue W.

    In: Biochemistry, Vol. 47, No. 35, 2008, p. 9198-207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. / Hatse, Sigrid; Princen, Katrien; De Clercq, Erik; Rosenkilde, Mette M; Schwartz, Thue W; Hernandez-Abad, Pedro E; Skerlj, Renato T; Bridger, Gary J; Schols, Dominique.

    In: Biochemical Pharmacology, Vol. 70, No. 5, 2005, p. 752-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI. / Rosenkilde, Mette M; Andersen, Michael B; Nygaard, Rie; Frimurer, Thomas M; Schwartz, Thue W.

    In: Molecular Pharmacology, Vol. 71, No. 3, 2006, p. 930-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors. / Schwartz, Thue W; Holst, Birgitte.

    In: Journal of Receptors and Signal Transduction, Vol. 26, No. 1-2, 2006, p. 107-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74. / Rosenkilde, M M; Kledal, T N; Bräuner-Osborne, Hans; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 274, No. 2, 08.01.1999, p. 956-961.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? / Schwartz, Thue W; Holst, Birgitte.

    In: TIPS - Trends in Pharmacological Sciences, Vol. 28, No. 8, 2007, p. 366-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. / Els, Sylvia; Schild, Enrico; Petersen, Pia Steen; Kilian, Tom-Marten; Mokrosinski, Jacek; Frimurer, Thomas M; Chollet, Constance; Schwartz, Thue W; Holst, Birgitte; Beck-Sickinger, Annette G.

    In: Journal of Medicinal Chemistry, Vol. 55, No. 17, 13.09.2012, p. 7437-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    An enteroendocrine full package solution. / Schwartz, Thue W; Holst, Birgitte.

    In: Cell Metabolism, Vol. 11, No. 6, 2010, p. 445-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Biased Gs Versus Gq Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network. / Valentin-Hansen, Louise; Frimurer, Thomas M; Mokrosinski, Jacek; Holliday, Nicholas D; Schwartz, Thue W.

    In: The Journal of Biological Chemistry, Vol. 290, No. 40, 02.10.2015, p. 24495-508.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119. / Hassing, Helle A; Fares, Suzan; Larsen, Olav; Pad, Hamideh; Pedersen, Maria Hauge; Jones, Robert M; Schwartz, Thue W; Hansen, Harald S; Rosenkilde, Mette M.

    In: Biochemical Pharmacology, Vol. 119, No. 1, 26.08.2016, p. 66-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Bidirectional GPR119 agonism requires peptide YY and glucose for activity in mouse and human colon mucosa. / Tough, Iain R; Forbes, Sarah; Herzog, Herbert; Jones, Robert M; Schwartz, Thue W; Cox, Helen M.

    In: Endocrinology, Vol. 159, No. 4, 19.02.2018, p. 1704-1717.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists. / Larson, D.L.; Jones, R.M.; Hjorth, Siv A.; Schwartz, Thue W.; Portoghese, P.S.

    In: Journal of Medicinal Chemistry, No. 43, no. 8, 2000, p. 1573-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics. / Park, Minyoung; Sivertsen, Bjørn Behrens; Els-Heindl, Sylvia; Huber, Thomas; Holst, Birgitte; Beck-Sickinger, Annette G.; Schwartz, Thue W.; Sakmar, Thomas P.

    In: Chemistry & Biology, Vol. 22, No. 11, 19.11.2015, p. 1431-1436.

    Research output: Contribution to journalLetterResearchpeer-review

  22. Published

    Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors. / Tian, He; Naganathan, Saranga; Kazmi, Manija A; Schwartz, Thue W.; Sakmar, Thomas P; Huber, Thomas.

    In: ChemBioChem, Vol. 15, No. 12, 18.08.2014, p. 1820-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    C-terminal KDEL-modified cystatin C is retained in transfected CHO cells. / Johansen, Teit Eliot; Vogel, Charlotte Katrine; Schwartz, Thue W.

    In: Biochemical and Biophysical Research Communications, Vol. 172, No. 3, 1990, p. 1384-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor. / Casarosa, Paola; Waldhoer, Maria; LiWang, Patricia J; Vischer, Henry F; Kledal, Thomas; Timmerman, Henk; Schwartz, Thue W; Smit, Martine J; Leurs, Rob.

    In: Journal of Biological Chemistry, Vol. 280, No. 5, 2005, p. 3275-3285.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection. / Klasse, P.J.; Rosenkilde, Mette Marie; Signoret, N.; Pelchen-Matthews, A.; Schwartz, Thue W.; Marsh, M.

    In: Journal of Virology, No. 73, no. 9, 1999, p. 7453-7466.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Characterization of G-protein coupled receptor kinase interaction with the NK-1 receptor using BRET. / Joergensen, R.; Holliday, N.D.; Hansen, J.L.; Vrecl, M.; Heding, A.; Elling, C.E.; Schwartz, Thue W.

    In: Molecular Pharmaceutics, Vol. 73, No. 2, 2008, p. 349-358.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer. / Jorgensen, Rasmus; Holliday, Nicholas D; Hansen, Jakob L; Vrecl, Milka; Heding, Anders; Schwartz, Thue W; Elling, Christian E.

    In: Molecular Pharmacology, Vol. 73, No. 2, 2007, p. 349-58.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype. / Jorgensen, Rasmus; Martini, Lene; Schwartz, Thue W; Elling, Christian E.

    In: Molecular Endocrinology, Vol. 19, No. 3, 2005, p. 812-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands. / Turcatti, G.; Drozda, S.E.; Chassaing, G.; Schwartz, Thue W.; Chollet, André; Jensen, Sannah Zoffmann; Lowe III, J.A.

    In: Journal of Biological Chemistry, No. 272, no. 34, 1997, p. 21167-21175.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Characterizaton of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype. / Jorgensen, R.; Martini, Lene; Schwartz, Thue W.; Elling, Christian E.

    In: Molecular Endocrinology, No. Vol. 19, no.3, 2005, p. 812-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Common structural basis for constitutive activity of the ghrelin receptor family. / Holst, Birgitte; Holliday, Nicholas D; Bach, Anders; Elling, C E; Cox, Helen M; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 279, No. 51, 2004, p. 53806-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V. / Rosenkilde, Mette M; David, Ralf; Oerlecke, Ilka; Benned-Jensen, Tau; Geumann, Ulf; Beck-Sickinger, Anette G; Schwartz, Thue W.

    In: Molecular Pharmacology, Vol. 70, No. 6, 2006, p. 1892-901.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Conservation of a helix-stabilizing dipole moment in the PP-fold family of regulatory peptides. / Bjørnholm, B; Jørgensen, Flemming Steen; Schwartz, T W.

    In: Biochemistry, Vol. 32, No. 12, 1993, p. 2954-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation. / Nygaard, Rie; Hansen, Louise Valentin; Mokrosinski, Jacek; Frimurer, Thomas M; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 285, No. 25, 2010, p. 19625-36.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Constitutive activity of glucagon receptor mutants. / Hjorth, Siv A.; Ørskov, Cathrine; Schwartz, Thue W.

    In: Molecular Endocrinology, No. 12, no. 1, 1998, p. 78-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Constitutive and regulated activities of virus-encoded 7TM receptors. / Rosenkilde, Mette Marie; Schwartz, Thue W.

    Handbook of Cellular Signalling. Chapter 29. ed. 2004. p. 173-76.

    Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

  37. Published

    Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. / Holst, Birgitte; Schwartz, Thue W.

    In: TIPS - Trends in Pharmacological Sciences, Vol. 25, No. 3, 2004, p. 113-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Construction of covalently coupled, concatameric dimers of 7TM receptors. / Terpager, Marie; Scholl, D Jason; Kubale, Valentina; Martini, Lene; Elling, Christian E; Schwartz, Thue W.

    In: Journal of Receptors and Signal Transduction, Vol. 29, No. 5, 2009, p. 235-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor. / Elling, C E; Thirstrup, K; Holst, Birgitte; Schwartz, T W.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 22, 1999, p. 12322-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Conversion of agonist site to metal-ion chelator site in the ¿2-adrenergic receptor. / Elling, Christian E.; Thirstrup, Kenneth; Holst, Birgitte; Schwartz, Thue W.

    In: Proceedings of the National Academy of Science of the United States of America, No. 96, no. 22, 1999, p. 12322-12327.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system : new aspects on Alzheimer's disease. / Ádori, Csaba; Glück, Laura; Barde, Swapnali; Yoshitake, Takashi; Kovacs, Gabor G; Mulder, Jan; Maglóczky, Zsófia; Havas, László; Bölcskei, Kata; Mitsios, Nicholas; Uhlén, Mathias; Szolcsányi, János; Kehr, Jan; Rönnbäck, Annica; Schwartz, Thue; Rehfeld, Jens F; Harkany, Tibor; Palkovits, Miklós; Schulz, Stefan; Hökfelt, Tomas.

    In: Acta Neuropathologica, Vol. 129, No. 4, 04.2015, p. 541-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. / Petersen, Pia Steen; Jin, Chunyu; Madsen, Andreas Nygaard; Rasmussen, Maria; Kuhre, Rune; Egerod, Kristoffer L; Nielsen, Lars Bo; Schwartz, Thue W; Holst, Birgitte.

    In: FASEB Journal, 22.07.2011, p. 3803-3814.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Den normale hjerne : Ny viden på flere fronter. / Pakkenberg, Bente; Gundersen, Hans Jørgen G.; Mortensen, Erik Lykke; Lauritzen, Martin J.; Jeune, Bernard; Regeur, Lisbeth; West, Mark J.; Schwartz, Thue W.

    In: Ugeskrift for Laeger, Vol. 159, No. 6, 01.12.1997, p. 723-727.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom. / Rosenkilde, Mette M; Schwartz, Thue W.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 112, No. 7-8, 2004, p. 481-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Differential regulation of CXCR4 and CCR5 endocytosis. / Signoret, N.; Rosenkilde, Mette Marie; Klasse, P.J.; Schwartz, Thue W.; Malim, M.H.; Hoxie, J.A.; Marsh, M.

    In: Journal of Cell Science, No. 111, no. 18, 1998, p. 2819-2830.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Dissecting signaling and functions of adhesion G protein-coupled receptors. / Araç, Demet; Aust, Gabriela; Calebiro, Davide; Engel, Felix B; Formstone, Caroline; Goffinet, André; Hamann, Jörg; Kittel, Robert J; Liebscher, Ines; Lin, Hsi-Hsien; Monk, Kelly R; Petrenko, Alexander; Piao, Xianhua; Prömel, Simone; Schiöth, Helgi B; Schwartz, Thue W.; Stacey, Martin; Ushkaryov, Yuri A; Wobus, Manja; Wolfrum, Uwe; Xu, Lei; Langenhan, Tobias.

    In: Annals of the New York Academy of Sciences, Vol. 1276, 12.2012, p. 1-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. / Heydorn, Arne; Søndergaard, Birgitte P; Hadrup, Niels; Holst, Birgitte; Haft, Carol Renfrew; Schwartz, Thue W.

    In: FEBS Letters, Vol. 556, No. 1-3, 2004, p. 276-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Disulfide bridge engineering in the tachykinen NK1 receptor. / Elling, Christian E.; Raffetseder, Ute; Nielsen, Søren M.; Schwartz, Thue W.

    In: Biochemistry, No. 39, no. 4, 2000, p. 667-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. / Manfra, Ornella; Van Craenenbroeck, Kathleen; Skieterska, Kamila; Frimurer, Thomas; Schwartz, Thue W.; Levy, Finn Olav; Andressen, Kjetil Wessel.

    In: A C S Chemical Neuroscience, Vol. 6, No. 7, 07.2015, p. 1206–1218.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Dual agonistic and antagonistic proberty of non-peptide angiotensin AT1 ligands: Susceptibility to receptor mutations. / Perlman, Signe; Costa-Neto, C.M.; Miyakawa, A.A.; Schambye, Hans T.; Hjorth, Siv A.; Paiva, A.C.; Rivero, R.A.; Greenlee, W.J.; Schwartz, Thue W.

    In: Molecular Pharmaceutics, No. 51, no. 2, 1997, p. 301-311.

    Research output: Contribution to journalJournal articleResearchpeer-review

Previous 1 2 3 4 5 Next

ID: 11601