Thue W. Schwartz

Thue W. Schwartz

Professor

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85

  • Nutrient and Metabolite Sensing

    Blegdamsvej 3B, Building: 07-6-85

    2200 København N

    Denmark


  1. 2010
  2. Published

    Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII. / Gbahou, F; Holst, B; Schwartz, T W.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 333, No. 1, 2010, p. 51-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. / Gjesing, Anette P.; Larsen, Lesli Hingstrup; Torekov, Signe Sørensen; Hainerová, Irena Aldhoon; Kapur, Rahul; Johansen, Anders; Albrechtsen, Anders; Boj, Sylvia; Holst, Birgitte; Harper, Angela; Urhammer, Søren A.; Borch-Johnsen, Knut; Pisinger, Charlotta Holm; Echwald, Søren M; Eiberg, Hans Rudolf Lytchoff; Astrup, Arne; Lebl, Jan; Ferrer, Jorge; Schwartz, Thue W.; Hansen, Torben; Pedersen, Oluf.

    In: P L o S One, Vol. 5, No. 4, 2010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. / Holst, Birgitte; Nygaard, Rie; Hansen, Louise Valentin; Bach, Anders; Engelstoft, Maja S; Petersen, Pia S; Frimurer, Thomas M; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 285, No. 6, 2010, p. 3973-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. / Li, Yingrui; Vinckenbosch, Nicolas; Tian, Geng; Huerta-Sanchez, Emilia; Jiang, Tao; Jiang, Hui; Albrechtsen, Anders; Andersen, Gitte; Cao, Hongzhi; Korneliussen, Thorfinn Sand; Grarup, Niels; Guo, Yiran; Hellman, Ines; Jin, Xin; Li, Qibin; Liu, Jiangtao; Liu, Xiao; Sparsø, Thomas; Tang, Meifang; Wu, Honglong; Wu, Renhua; Yu, Chang; Zheng, Hancheng; Astrup, Arne; Bolund, Lars; Holmkvist, Johan; Jørgensen, Torben; Kristiansen, Karsten; Schmitz, Ole; Schwartz, Thue W; Zhang, Xiuqing; Li, Ruiqiang; Yang, Huanming; Wang, Jian; Hansen, Torben; Pedersen, Oluf; Nielsen, Rasmus; Wang, Jun.

    In: Nature Genetics, Vol. 42, No. 11, 2010, p. 969-72.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation. / Nygaard, Rie; Hansen, Louise Valentin; Mokrosinski, Jacek; Frimurer, Thomas M; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 285, No. 25, 2010, p. 19625-36.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The minor binding pocket: a major player in 7TM receptor activation. / Rosenkilde, Mette Marie; Benned-Jensen, Tau; Frimurer, Thomas M.; Schwartz, Thue W.

    In: Trends in Pharmacological Sciences, Vol. 31, No. 12, 2010, p. 567-574.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    An enteroendocrine full package solution. / Schwartz, Thue W; Holst, Birgitte.

    In: Cell Metabolism, Vol. 11, No. 6, 2010, p. 445-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Targeting CXCR4 in HIV Cell-Entry Inhibition. / Steen, Anne; Schwartz, T W; Rosenkilde, M M.

    In: Mini reviews in medicinal chemistry, Vol. 9, No. 14, 2010, p. 1605-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2009
  11. Published

    [Fine needle aspiration cytology of mammography screening]. / Engvad, B.; Laenkholm, A.V.; Schwartz, Thue W.; Bak, M.

    In: Ugeskrift for læger, Vol. 171, No. 34, 2009, p. 2379-2382.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. / Holst, Birgitte; Egerod, Kristoffer L; Jin, Chunyu; Petersen, Pia Steen; Østergaard, Mette Viberg; Hald, Jacob; Sprinkel, A M Ejernaes; Størling, Joachim; Mandrup-Poulsen, Thomas; Holst, Jens J; Thams, Peter; Orskov, Cathrine; Wierup, Nils; Sundler, Frank; Madsen, Ole D; Schwartz, Thue W.

    In: Endocrinology, Vol. 150, No. 6, 2009, p. 2577-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Ligand binding and micro-switches in 7TM receptor structures. / Nygaard, Rie; Frimurer, Thomas M; Holst, Birgitte; Rosenkilde, Mette M; Schwartz, Thue W.

    In: TIPS - Trends in Pharmacological Sciences, Vol. 30, No. 5, 2009, p. 249-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Construction of covalently coupled, concatameric dimers of 7TM receptors. / Terpager, Marie; Scholl, D Jason; Kubale, Valentina; Martini, Lene; Elling, Christian E; Schwartz, Thue W.

    In: Journal of Receptors and Signal Transduction, Vol. 29, No. 5, 2009, p. 235-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2008
  16. Published

    A gut feeling for obesity: 7TM sensors on enteroendocrine cells. / Engelstoft, Maja Storm; Egerod, Kristoffer L; Holst, Birgitte; Schwartz, Thue W.

    In: Cell Metabolism, Vol. 8, No. 6, 2008, p. 447-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. / Holst, Birgitte; Frimurer, Thomas M; Mokrosinski, Jacek; Halkjaer, Tine; Cullberg, Karina B; Underwood, Christina R; Schwartz, Thue W.

    In: Molecular Pharmacology, Vol. 75, No. 1, 2008, p. 44-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. / Jensen, Pia C; Thiele, Stefanie; Ulven, Trond; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Journal of Biological Chemistry, Vol. 283, No. 34, 2008, p. 23121-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. / Jensen, Pia C; Thiele, Stefanie; Ulven, Trond; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Journal of Biological Chemistry, Vol. 283, No. 34, 17.06.2008, p. 23121-23128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Characterization of G-protein coupled receptor kinase interaction with the NK-1 receptor using BRET. / Joergensen, R.; Holliday, N.D.; Hansen, J.L.; Vrecl, M.; Heding, A.; Elling, C.E.; Schwartz, Thue W.

    In: Molecular Pharmaceutics, Vol. 73, No. 2, 2008, p. 349-358.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Structural biology: A moving story of receptors. / Schwartz, Thue W; Hubbell, Wayne L.

    In: Nature, Vol. 455, No. 7212, 2008, p. 473-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39. / Storjohann, Laura; Holst, Birgitte; Schwartz, Thue W.

    In: Biochemistry, Vol. 47, No. 35, 2008, p. 9198-207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. / Storjohann, Laura; Holst, Birgitte; Schwartz, Thue W.

    In: FEBS Letters, Vol. 582, No. 17, 2008, p. 2583-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2007
  25. Published

    GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue. / Egerod, Kristoffer L; Holst, Birgitte; Petersen, Pia S; Hansen, Jacob B; Mulder, Jan; Hökfelt, Tomas; Schwartz, Thue W.

    In: Molecular Endocrinology, Vol. 21, No. 7, 2007, p. 1685-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor. / Hatse, Sigrid; Huskens, Dana; Princen, Katrien; Vermeire, Kurt; Bridger, Gary J; De Clercq, Erik; Rosenkilde, Mette M; Schwartz, Thue W; Schols, Dominique.

    In: Journal of Virology, Vol. 81, No. 7, 2007, p. 3632-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor. / Holliday, Nicholas D; Holst, Birgitte; Rodionova, Elena A; Schwartz, Thue W; Cox, Helen M.

    In: Molecular Endocrinology, Vol. 21, No. 12, 2007, p. 3100-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. / Holst, Birgitte; Mokrosinski, Jacek; Lang, Manja; Brandt, Erik; Nygaard, Rie; Frimurer, Thomas M; Beck-Sickinger, Annette G; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 282, No. 21, 2007, p. 15799-811.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. / Jensen, Pia C; Nygaard, Rie; Thiele, Stefanie; Elder, Amy; Zhu, Guoming; Kolbeck, Roland; Ghosh, Shomir; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Molecular Pharmacology, Vol. 72, No. 2, 2007, p. 327-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 11601