Oluf Borbye Pedersen

Oluf Borbye Pedersen

Professor


  1. 1991
  2. Published

    Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients. / Vestergaard, H; Bjørbaek, C; Andersen, P H; Bak, J F; Pedersen, O.

    In: Diabetes, Vol. 40, No. 12, 12.1991, p. 1740-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 1993
  4. Published

    The effect of intensive insulin therapy on the insulin-regulatable glucose transporter (GLUT4) expression in skeletal muscle in type 1 diabetes. / Andersen, P H; Vestergaard, H; Lund, S; Vedel, Peter; Junker, Steffen; Kahn, B B; Pedersen, O.

    In: Diabetic Medicine, Vol. 10, No. 8, 10.1993, p. 699-706.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. / Almind, K; Bjørbaek, C; Vestergaard, H; Hansen, Torben; Echwald, Søren Morgenthaler; Pedersen, O.

    In: Lancet, Vol. 342, No. 8875, 02.10.1993, p. 828-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus. / Hansen, Torben; Bjørbaek, C; Vestergaard, H; Grønskov, K; Bak, J F; Pedersen, O.

    In: The Journal of clinical endocrinology and metabolism, Vol. 77, No. 6, 12.1993, p. 1500-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 1994
  8. Published

    Expression of glycogen synthase and phosphofructokinase in muscle from type 1 (insulin-dependent) diabetic patients before and after intensive insulin treatment. / Vestergaard, H; Andersen, P H; Lund, S; Vedel, Peter; Pedersen, O.

    In: Diabetologia, Vol. 37, No. 1, 01.1994, p. 82-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM. / Bjørbaek, C; Echwald, Søren Morgenthaler; Hubricht, P; Vestergaard, H; Hansen, Torben; Zierath, J; Pedersen, O.

    In: Diabetes, Vol. 43, No. 8, 08.1994, p. 976-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM. / Chen, Y H; Hansen, L; Chen, Min; Bjørbaek, C; Vestergaard, H; Hansen, T; Cohen, Peter; Pedersen, O; Vestergaard, Henrik.

    In: Diabetes, Vol. 43, No. 10, 10.1994, p. 1234-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 1995
  12. Published

    Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects : a longitudinal study. / Vestergaard, H; Weinreb, J E; Rosen, A S; Bjørbaek, C; Hansen, L; Pedersen, O; Kahn, B B.

    In: The Journal of clinical endocrinology and metabolism, Vol. 80, No. 1, 01.1995, p. 270-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity. / Echwald, Søren Morgenthaler; Bjørbaek, C; Hansen, Torben; Clausen, J O; Vestergaard, H; Zierath, J R; Printz, R L; Granner, D K; Pedersen, O.

    In: Diabetes, Vol. 44, No. 3, 03.1995, p. 347-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy. / Vestergaard, H; Klein, H H; Hansen, T; Müller, J; Skovby, F; Bjørbaek, C; Røder, M E; Pedersen, O; Vestergaard, Henrik.

    In: The Journal of Clinical Investigation, Vol. 95, No. 4, 04.1995, p. 1925-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Unchanged gene expression of glycogen synthase in muscle from patients with NIDDM following sulphonylurea-induced improvement of glycaemic control. / Vestergaard, H; Lund, S; Bjørbaek, C; Pedersen, O.

    In: Diabetologia, Vol. 38, No. 10, 10.1995, p. 1230-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM. / Klein, H H; Vestergaard, H; Kotzke, G; Pedersen, O.

    In: Diabetes, Vol. 44, No. 11, 11.1995, p. 1310-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 1996
  18. Published

    Impaired insulin-stimulated nonoxidative glucose metabolism in glucose-tolerant women with previous gestational diabetes. / Damm, P; Vestergaard, H; Kühl, Carl Erik; Pedersen, O.

    In: American Journal of Obstetrics and Gynecology, Vol. 174, No. 2, 02.1996, p. 722-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Studies of insulin resistance in congenital generalized lipodystrophy. / Søvik, O; Vestergaard, H; Trygstad, O; Pedersen, O.

    In: Acta Paediatrica. Supplement, Vol. 413, 06.1996, p. 29-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 1997
  21. Published

    Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase : effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index. / Hansen, Torben; Andersen, C B; Echwald, Søren Morgenthaler; Urhammer, S A; Clausen, J O; Vestergaard, H; Owens, D; Hansen, L; Pedersen, O.

    In: Diabetes, Vol. 46, No. 3, 03.1997, p. 494-501.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Short- and long-term metabolic effects of recombinant human IGF-I treatment in patients with severe insulin resistance and diabetes mellitus. / Vestergaard, H; Rossen, M; Urhammer, S A; Müller, J; Pedersen, O.

    In: European Journal of Endocrinology, Vol. 136, No. 5, 05.1997, p. 475-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM. / Hansen, L; Arden, K C; Rasmussen, S B; Viars, C S; Vestergaard, H; Hansen, T; Møller, A M; Woodgett, J R; Pedersen, O.

    In: Diabetologia, Vol. 40, No. 8, 08.1997, p. 940-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Expression of protein-tyrosine phosphatases in the major insulin target tissues. / Norris, K; Norris, F; Kono, D H; Vestergaard, H; Pedersen, O; Theofilopoulos, A N; Møller, N P.

    In: FEBS letters, Vol. 415, No. 3, 06.10.1997, p. 243-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 1998
  26. Published

    The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1α gene on estimates of the pancreatic β-cell function in Caucasian glucosetolerant first-degree relatives of type 2 diabetic patients. / Urhammer, Søren A.; Møller, Ann Merete; Nyholm, Birgit; Ekstrøm, Claus T.; Eiberg, Hans; Clausen, Jesper O.; Hansen, Torben; Pedersen, Oluf; Schmitz, Ole.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 83, No. 11, 20.11.1998, p. 3992-3995.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published
  28. 1999
  29. Published

    Alternative splicing of exon 17 and a missense mutation in exon 20 of the insulin receptor gene in two brothers with a novel syndrome of insulin resistance (congenital fiber-type disproportion myopathy). / Vorwerk, P; Christoffersen, C T; Müller, J; Vestergaard, H; Pedersen, O; De Meyts, P; Vestergaard, Henrik.

    In: Hormone Research, Vol. 52, No. 5, 1999, p. 211-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Intermediate Expansions of a GAA Repeat in the Frataxin Gene are not associated with Type 2 Diabetes or Altered Glucose-Induced ¿-cell function in Danish Caucasians. / Dalgaard, Louise Torp; Hansen, Torben; Urhammer, S.A.; Clausen, Jesper O.; Eiberg, Hans Rudolf Lytchoff; Pedersen, Oluf.

    In: Diabetes, No. 48, 1999, p. 914-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Implications of compound heterozygous insulin receptor mutations in congenital muscle fibre type disproportion myopathy for the receptor kinase activation. / Klein, H H; Müller, R; Vestergaard, H; Pedersen, O.

    In: Diabetologia, Vol. 42, No. 2, 02.1999, p. 245-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published
  33. Published

    Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene : Evaluation of their relation with alterations in insulin secretion and insulin sensitivity. / Almind, K.; Frederiksen, S. K.; Bernal, D.; Hansen, T.; Ambye, L.; Urhammer, S.; Ekstrøm, C. T.; Berglund, L.; Reneland, R.; Lithell, H.; White, M. F.; Van Obberghen, E.; Pedersen, O.

    In: Diabetologia, Vol. 42, No. 10, 11.10.1999, p. 1244-1249.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2000
  35. Published

    The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians. / Rasmussen, S. K.; Urhammer, S. A.; Pizzuti, A.; Echwald, S. M.; Ekstrom, C. T.; Hansen, L.; Hansen, T.; Borch-Johnsen, K.; Frittitta, L.; Trischitta, V.; Pedersen, O.

    In: Diabetes, Vol. 49, No. 9, 01.01.2000, p. 1608-1611.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus. / Rasmussen, Søren K.; Lautier, Corinne; Hansen, Lars; Echwald, Søren M.; Hansen, Torben; Ekstrøm, Claus T.; Urhammer, Søren A.; Borch-Johnsen, Knut; Grigorescu, Florin; Smith, Robert J.; Pedersen, Oluf.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 85, No. 4, 01.12.2000, p. 1606-1610.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2001
  38. Published

    A prevalent polymorphism in the putative promotor of the UCP3 gene and its relationship to body mass index in the Danish population. / Dalgaard, Louise Torp; Sørensen, Thorkild I.A.; Drivsholm, Thomas Bo; Borch-Johnsen, Knut; Andersen, T.; Hansen, T.; Pedersen, Oluf.

    In: Journal of Clinical Endocrinology and Metabolism, No. 86, 2001, p. 1398-1402.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency. / Buemann, B.; Schierning, B.; Toubro, S.; Bibby, B. M.; Sørensen, Thorkild I.A.; Dalgaard, L.; Pedersen, Oluf; Astrup, A.

    In: International Journal of Obesity, Vol. 25, 2001, p. 467-471.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus. / Hansen, L; Jensen, J N; Ekstrøm, C T; Vestergaard, H; Hansen, T; Pedersen, O; Vestergaard, Henrik.

    In: Diabetologia, Vol. 44, No. 2, 02.2001, p. 237-240.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Serum leptin levels in pregnant women with type 1 diabetes mellitus. / Lauszus, Finn; Schmitz, Ole; Vestergaard, H; Klebe, J G; Pedersen, O; Vestergaard, Henrik.

    In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 80, No. 7, 07.2001, p. 596-601.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Rosiglitazone treatment of patients with extreme insulin resistance and diabetes mellitus due to insulin receptor mutations has no effects on glucose and lipid metabolism. / Vestergaard, H; Lund, S; Pedersen, O; Vestergaard, Henrik.

    In: Journal of Internal Medicine, Vol. 250, No. 5, 11.2001, p. 406-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. 2002
  44. Published

    Fat mass measured by DXA varies with scan velocity. / Black, Eva; Petersen, Liselotte; Kreutzer, Martin; Toubro, Søren; Sørensen, Thorkild I A; Pedersen, Oluf; Astrup, Arne.

    In: Obesity, Vol. 10, No. 2, 2002, p. 69-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function. / Hansen, Sara K; Párrizas, Marcelina; Jensen, Maria L; Pruhova, Stepanka; Ek, Jakob; Boj, Sylvia F; Johansen, Anders; Maestro, Miguel A; Rivera, Francisca; Eiberg, Hans; Andel, Michal; Lebl, Jan; Pedersen, Oluf; Ferrer, Jorge; Hansen, Torben.

    In: Journal of Clinical Investigation, Vol. 110, No. 6, 2002, p. 827-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Jagten på de genetiske determinanter for de formodede polygene former for type 2-diabetes. Status og perspektivering. / Pedersen, Oluf Borbye; Hansen, Torben; Hansen, Lars; Echwald, Søren Morgenthaler; Urhammer, Søren A.

    In: Ugeskrift for Laeger, Vol. 164, No. 16, 2002, p. 2163-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. / Buhl, Esben Selmer; Jessen, Niels; Pold, Rasmus; Ledet, Thomas; Flyvbjerg, Allan; Pedersen, Steen B; Pedersen, Oluf; Schmitz, Ole; Lund, Sten.

    In: Diabetes, Vol. 51, No. 7, 2002, p. 2199-206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Maturity-onset diabetes of the young--MODY. Molekylaergenetiske, patofysiologiske og kliniske karakteristika. / Hansen, Torben; Urhammer, Søren A; Pedersen, Oluf Borbye.

    In: Ugeskrift for Laeger, Vol. 164, No. 15, 2002, p. 2017-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients. / Jacobsen, Peter; Grarup, Niels; Tarnow, Lise; Parving, Hans-Henrik; Pedersen, Oluf.

    In: Nephrology, Dialysis, Transplantation, Vol. 17, No. 8, 2002, p. 1408-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. / Rasmussen, Søren K; Urhammer, Søren A; Berglund, Lars Erik; Jensen, Jan N; Hansen, Lars; Echwald, Søren Morgenthaler; Borch-Johnsen, Knut; Horikawa, Yukio; Mashima, Hirosato; Lithell, Hans; Cox, Nancy J; Hansen, Torben; Bell, Graeme I; Pedersen, Oluf.

    In: Diabetes, Vol. 51, No. 12, 2002, p. 3561-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha. / Almind, Katrine; Delahaye, Laurent; Hansen, Torben; Van Obberghen, Emmanuel; Pedersen, Oluf; Kahn, C Ronald.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 4, 19.02.2002, p. 2124-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2003
  53. Published

    A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. / Muller, Yunhua Li; Bogardus, Clifton; Pedersen, Oluf; Baier, Leslie.

    In: Diabetes, Vol. 52, No. 3, 2003, p. 895-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    A genome-wide scan in families with maturity-onset diabetes of the young : evidence for further genetic heterogeneity. / Frayling, Timothy M; Lindgren, Cecilia M; Chevre, Jean Claude; Menzel, Stephan; Wishart, Marie; Benmezroua, Yamina; Brown, Alison; Evans, Julie C; Rao, Pamidghantam Subba; Dina, Christian; Lecoeur, Cécile; Kanninen, Timo; Almgren, Peter; Bulman, Michael P; Wang, Youxiang; Mills, James; Wright-Pascoe, Rosemarie; Mahtani, Melanie M; Prisco, Francesco; Costa, Angels; Cognet, Ignacio; Hansen, Torben; Pedersen, Oluf; Ellard, Sian; Tuomi, Tiinamaija; Groop, Leif C; Froguel, Philippe; Hattersley, Andrew T; Vaxillaire, Martine.

    In: Diabetes, Vol. 52, No. 3, 2003, p. 872-81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects. / Nielsen, Eva-Maria D; Hansen, Lars; Echwald, Søren Morgenthaler; Drivsholm, Thomas; Borch-Johnsen, Knut; Ekstrøm, Claus Thorn; Hansen, Torben; Pedersen, Oluf.

    In: Pharmacogenetics and Genomics, Vol. 13, No. 7, 2003, p. 417-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Impact of low-dose acetylsalicylic acid on kidney function in type 2 diabetic patients with elevated urinary albumin excretion rate. / Gaede, Peter; Hansen, Henrik Post; Parving, Hans-Henrik; Pedersen, Oluf.

    In: Nephrology, Dialysis, Transplantation, Vol. 18, No. 3, 2003, p. 539-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins : thrifty genotype, thrifty phenotype, or both? / Poulsen, Pernille; Andersen, Gitte; Fenger, Mogens; Hansen, Torben; Echwald, Søren Morgenthaler; Vølund, Aage; Beck-Nielsen, Henning; Pedersen, Oluf; Vaag, Allan.

    In: Diabetes, Vol. 52, No. 1, 2003, p. 194-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Insulin resistance and maximal oxygen uptake. / Seibaek, Marie; Vestergaard, Henrik; Burchardt, Hans; Sloth, Carsten; Torp-Pedersen, Christian; Nielsen, Steen Levin; Hildebrandt, Per; Pedersen, Oluf.

    In: Clinical Cardiology, Vol. 26, No. 11, 2003, p. 515-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Intensified multifactorial intervention and cardiovascular outcome in type 2 diabetes : the Steno-2 study. / Pedersen, Oluf; Gaede, Peter.

    In: Metabolism, Vol. 52, No. 8 Suppl 1, 2003, p. 19-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Leptin and bone mineral density : a cross-sectional study in obese and nonobese men. / Morberg, Cathrine M.; Tetens, Inge; Black, Eva; Toubro, Søren; Sørensen, Thorkild I.A.; Pedersen, Oluf Borbye; Astrup, Arne.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 88, No. 12, 2003, p. 5795-5800.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. / Gaede, Peter; Vedel, Pernille; Larsen, Nicolai; Jensen, Gunnar V H; Parving, Hans-Henrik; Pedersen, Oluf.

    In: Briefings from the New England Journal of Medicine, Vol. 348, No. 5, 2003, p. 383-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Steno-2-studiet : intensiv multifaktoriel behandling reducerer forekomsten af kardiovaskulaer sygdom hos patienter med type 2-diabetes. / Gaede, Peter Haulund; Jepsen, Pernille Vedel; Larsen, Jens Nicolai Brink; Jensen, Gunnar Vagn; Parving, Hans-Henrik; Pedersen, Oluf Borbye.

    In: Ugeskrift for Laeger, Vol. 165, No. 26, 2003, p. 2658-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

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