Morten Hanefeld Dziegiel

Morten Hanefeld Dziegiel

Postgraduate clinical associate prof.

Primary fields of research

Our general focus is feto-maternal alloimmuno disease.

The main focus of my group is the elucidation of the molecular mechanism underlying gestational alloimmune liver disease abbreviated GALD. This disease causes acute liver failure in fetus and newborn and is often fatal. 

We are generally interested in mechanisms of immune destruction, immunoglobulins, effects of immunoglobulins, 'designer antibodies' with anti-hemolytic effect against anti-D antibodies, and recombinant therapeutic antibodies against Plasmodium falciparum.

A second interest is genetics of blood groups, and antenatal fetal blood group determination based on cell free fetal DNA in maternal plasma using PCR and Next Generation Sequencing (NGS).

For blood donors we have designed a complete panel of genetic assays for determination of all blood groups. 

We are now involved in the investigation of the feasibility of launching an 'RhD-like' effort for identification of pregnancies at risk of alloimmune thrombocytopenia. We have devised a cost-effective solution based on the same samples used for RhD typing and antibody screening.

My laboratory has investigated feto-maternal hemorrhage from fetus to mother by flow cytometry.

We use flow cytometry for sensitive and informative investigation of DAT positive erythrocytes.

 

DANSK

Interesseområder

Mine primære interesseomåder er føtomaternel immunhæmatologi.

Vores interesse er antistoffer, antistoffers effekter, 'designerantistoffer' med anti-hæmolytiske effekt overfor anti-D antistoffer samt antistoffer mod malariaparasitten. 

En anden interesse er blodtypers genetik, antenatale blodtypebestemmelser baseret på celle frit føtalt DNA i maternelt plasma med anvendelse af PCR og NGS.

Vores produktion af mere end 15.000 analyser af føtal RHD hos RHD negative gravide har muliggjort at vi har kunnet vise at preterm fødsel og præeklampsi kan prædikteres af vores kvantitering af celle frit føtalt DNA. 

Vi har forsket i metoder til måling af føtomaternel blødning ved flowcytometri.

Selected publications

  1. Published

    FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS

    Liu, Y., Carlsson, R., Comabella, M., Wang, J., Kosicki, M. K., Carrion, B., Hasan, M., Wu, X., Montalban, X., Dziegiel, M. H., Sellebjerg, F., Sørensen, P. S., Helin, K. & Navikas, S., 16 Feb 2014, In : Nature Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions

    Mathiesen, L., Nielsen, L. K., Andersen, J. T., Grevys, A., Sandlie, I., Michaelsen, T. E., Hedegaard, M., Knudsen, L. E. & Dziegiel, M. H., 10 Jul 2013, In : Blood. 122, 7, p. 1174-1181

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Report of the first nationally implemented clinical routine screening for fetal RHD in D- pregnant women to ascertain the requirement for antenatal RhD prophylaxis

    Clausen, F. B., Christiansen, M., Steffensen, R. N., Jørgensen, S., Nielsen, C., Jakobsen, M. A., Madsen, R. D., Jensen, K., Krog, G. R., Rieneck, K., Sprogøe, U., Homburg, K. M., Grunnet, N. & Dziegiel, M. H., 2012, In : Transfusion. 52, 4, p. 752-758

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Next-generation sequencing: proof of concept for antenatal prediction of the fetal Kell blood group phenotype from cell-free fetal DNA in maternal plasma

    Rieneck, K., Bak, M., Jønson, L., Clausen, F. B., Krog, G. R., Tommerup, N., Nielsen, L. K., Hedegaard, M. & Dziegiel, M. H., Nov 2013, In : Transfusion. 53, 11 Suppl 2, p. 2892-2898 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Identifying mild and severe preeclampsia in asymptomatic pregnant women by levels of cell-free fetal DNA

    Jakobsen, T. R., Clausen, F. B., Rode, L., Dziegiel, M. H. & Tabor, A., 16 Jan 2013, In : Transfusion.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery

    Jakobsen, T. R., Clausen, F. B., Rode, L., Dziegiel, M. H. & Tabor, A., Sep 2012, In : Journal of Prenatal Diagnosis and Therapy. 32, 9, p. 840-5 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Human recombinant antibodies against Plasmodium falciparum merozoite surface protein 3 cloned from peripheral blood leukocytes of individuals with immunity to malaria demonstrate antiparasitic properties

    Lundquist, R., Nielsen, L. K., Jafarshad, A., Soesoe, D., Christensen, L. H., Druilhe, P. & Dziegiel, M. H., Jun 2006, In : Infection and Immunity. 74, 6, p. 3222-31 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Recombinant anti-Plasmodium falciparum antibodies

    Dziegiel, M., Nielsen, L. K., Lundquist, R. & Druilhe, P., 2010, IPC No. JP4475949 (B2)

    Research output: PatentResearch

  9. Published

    Red blood cell antibodies in pregnancy and their clinical consequences: synergistic effects of multiple specificities

    Nordvall, M., Dziegiel, M. H., Hegaard, H. K., Bidstrup, M., Jonsbo, F., Christensen, B. & Hedegaard, M., Oct 2009, In : Transfusion. 49, 10, p. 2070-5 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle

    Borre, M. B., Dziegiel, M., Høgh, B., Pedersen, E., Rieneck, K., Riley, E., Meis, J. F., Aikawa, M., Nakamura, K. & Harada, M., 1991, In : Molecular and Biochemical Parasitology. 49, 1, p. 119-31 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Human anti-rhesus D IgG1 antibody produced in transgenic plants.

    Bouquin, T., Thomsen, M., Nielsen, L. K., Green, T. H., Mundy, J. & Dziegiel, M. H., 2002, In : Transgenic Research. 11, 2, p. 115-22 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 984777