Judith Margarete Gottwein

Judith Margarete Gottwein

Professor


  1. 2019
  2. Published

    Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants. / Jensen, Sanne Brun; Fahnøe, Ulrik; Pham, Long V.; Serre, Stéphanie Brigitte Nelly; Tang, Qi; Ghanem, Lubna; Pedersen, Martin Schou; Ramirez, Santseharay; Humes, Daryl; Pihl, Anne Finne; Filskov, Jonathan; Sølund, Christina Søhoel; Dietz, Julia; Fourati, Slim; Pawlotsky, Jean Michel; Sarrazin, Christoph; Weis, Nina; Schønning, Kristian; Krarup, Henrik; Bukh, Jens; Gottwein, Judith Margarete.

    In: Hepatology, Vol. 70, No. 3, 2019, p. 771-787.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape. / Pham, Long V.; Jensen, Sanne Brun; Fahnøe, Ulrik; Pedersen, Martin Schou; Tang, Qi; Ghanem, Lubna; Ramirez, Santseharay; Humes, Daryl; Serre, Stéphanie B.N.; Schønning, Kristian; Bukh, Jens; Gottwein, Judith M.

    In: Journal of Hepatology, Vol. 70, No. 3, 2019, p. 388-397.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2018
  5. Published

    Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1–7 and Escape Variants. / Gottwein, Judith M.; Pham, Long V.; Mikkelsen, Lotte S.; Ghanem, Lubna; Ramirez, Santseharay; Scheel, Troels K.H.; Carlsen, Thomas H.R.; Bukh, Jens.

    In: Gastroenterology, Vol. 154, No. 5, 04.2018, p. 1435-1448.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model. / Galli, Andrea; Mens, Helene; Gottwein, Judith M; Gerstoft, Jan; Bukh, Jens.

    In: Scientific Reports, Vol. 8, No. 1, 4619, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models. / Pham, Long; Ramirez Almeida, Santseharay; Gottwein, Judith Margarete; Fahnøe, Ulrik; Li, Yiping; Pedersen, Jannie; Bukh, Jens.

    In: Gastroenterology, Vol. 154, No. 8, 2018, p. 2194-2208.e12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals. / Pihl, Anne F.; Offersgaard, Anna F.; Mathiesen, Christian K.; Prentoe, Jannick; Fahnøe, Ulrik; Krarup, Henrik; Bukh, Jens; Gottwein, Judith M.

    In: Scientific Reports, Vol. 8, No. 1, 17505, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies. / Humes, Daryl; Ramirez, Santseharay; Jensen, Tanja B.; Li, Yi Ping; Gottwein, Judith M.; Bukh, Jens.

    In: Virology, Vol. 522, 2018, p. 177-192.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2017
  11. Published

    Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors. / Pham, Long V.; Ramirez Almeida, Santseharay; Carlsen, Thomas H R; Li, Yi-Ping; Gottwein, Judith M.; Bukh, Jens.

    In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 6, e00037-17, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2016
  13. Published

    Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir. / Ramirez Almeida, Santseharay; Mikkelsen, Lotte S.; Gottwein, Judith M.; Bukh, Jens.

    In: Gastroenterology, Vol. 151, No. 5, 11.2016, p. 973-985.e2.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2015
  15. Published

    Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance. / Jensen, Sanne B.; Serre, Stephanie B. N.; Humes, Daryl G.; Ramirez Almeida, Santseharay; Li, Yi-Ping; Bukh, Jens; Gottwein, Judith M.

    In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 12, 12.2015, p. 7426-7436.

    Research output: Contribution to journalJournal articleResearchpeer-review

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