Jesper Langgaard Kristensen

Jesper Langgaard Kristensen

Professor with special responsibilities

Primary fields of research

Research interests

Generally medicinal chemistry and the development of new methodology for the construction of compound classes of relevance to medicinal chemistry. Using these tools we are trying to develop new probes and tools that will help us to elucidate the underlying mechanisms responsible for the regulation of different pharmacological targets: Ion channels, enzymes and GPCR’s.

Please see group web-page for more informantion.

 - Member of the Horizon2020 “Click-It” consortium receiving 6 mio. Euro (2015-2020) where we are developing a new imaging technology based on in-vivo click-chemistry.

 - Member of the Marie Curie ETN "AlphaSy" consortium receiving 4.1 mio. Euro (2018-2022) where we are developing a new imaging agents to diagnose Parkisons disease at an early stage.

 - Coordinator of the ETN-EID project SAFER receiving 1.3 mio. Euro (2017-2021). SAFER aims to identify functionally Selective Agonists for the 5-HT2A Serotonin Receptor.

Selected publications

  1. E-pub ahead of print

    Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

    Clementson, S., Jessing, M., Pedersen, H., Vital, P. & Kristensen, J. L., 28 May 2019, In : Journal of the American Chemical Society.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

    Crestey, F., Jensen, A. A., Soerensen, C., Magnus, C. B., Andreasen T., J., Peters, G. H. J. & Kristensen, J. L., 2018, In : Journal of Medicinal Chemistry. 61, p. 1719-1729

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice

    Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, J. L., 2015, In : Psychopharmacology. 232, 6, p. 1039-47 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Metabolic fate of hallucinogenic NBOMes

    Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M. & Kristensen, J. L., 2016, In : Chemical Research in Toxicology. 29, 1, p. 96–100 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists

    Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, H. & Kristensen, J. L., 7 Jan 2014, In : A C S Chemical Neuroscience. 5, 3, p. 243-249 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1305029