Jens Juul Holst

Jens Juul Holst

Professor


  1. 2017
  2. Published

    On the relationship between glucose absorption and glucose‐stimulated secretion of GLP‐1, neurotensin, and PYY from different intestinal segments in the rat. / Kuhre, Rune Ehrenreich; Christiansen, Charlotte Bayer; Saltiel, Monika Yosifova; Albrechtsen, Nicolai Jacob Wewer; Holst, Jens Juul.

    In: Physiological Reports, Vol. 5, No. 23, e13507, 03.12.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Discovery, characterization, and clinical development of the glucagon-like peptides. / Drucker, Daniel J; Habener, Joel F; Holst, Jens Juul.

    In: The Journal of Clinical Investigation, Vol. 127, No. 12, 01.12.2017, p. 4217-4227.

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    Roles of increased glycemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass. / Tharakan, George; Behary, Preeshila; Wewer Albrechtsen, Nicolai Jacob; Chahal, Harvinder; Kenkre, Julia; Miras, Alexander D; Ahmed, Ahmed R; Holst, Jens Juul; Bloom, Steve R; Tan, Tricia Mei Mei.

    In: European Journal of Endocrinology, Vol. 177, 01.12.2017, p. 455-464.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Glucagon-like peptide-1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP-1 receptors. / Ronn, Jonas; Jensen, Elisa P; Wewer Albrechtsen, Nicolai J; Holst, Jens Juul; Sorensen, Charlotte M.

    In: Physiological Reports, Vol. 5, No. 23, e13503, 12.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response. / Tura, A.; Bagger, J. I.; Ferrannini, E.; Holst, J. J.; Knop, F. K.; Vilsbøll, T.; Mari, A.

    In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 27, No. 12, 12.2017, p. 1123-1129.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Nutrient re-routing and altered gut-islet cell crosstalk may explain early relief of severe postprandial hypoglycaemia after reversal of Roux-en-Y gastric bypass. / Svane, M S; Toft-Nielsen, M B; Kristiansen, V B; Hartmann, B; Holst, J J; Madsbad, S; Bojsen-Møller, K N.

    In: Diabetic Medicine Online, Vol. 34, No. 12, 12.2017, p. 1783-1787.

    Research output: Contribution to journalLetterResearchpeer-review

  8. Published

    Semaglutide seems to be more effective the other GLP-1Ras. / Holst, Jens Juul; Madsbad, Sten.

    In: Annals of Translational Medicine, Vol. 5, No. 24, 505, 12.2017.

    Research output: Contribution to journalComment/debateResearch

  9. Published

    Genetic determinants of circulating GIP and GLP-1 concentrations. / Almgren, Peter; Lindqvist, Andreas; Krus, Ulrika; Hakaste, Liisa; Ottosson-Laakso, Emilia; Asplund, Olof; Sonestedt, Emily; Prasad, Rashmi B; Laurila, Esa; Orho-Melander, Marju; Melander, Olle; Tuomi, Tiinamaija; Holst, Jens Juul; Nilsson, Peter M; Wierup, Nils; Groop, Leif; Ahlqvist, Emma.

    In: JCI Insight, Vol. 2, No. 21, e93306, 02.11.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Cross-Validation of a Glucose-Insulin-Glucagon Pharmacodynamics Model for Simulation Using Data From Patients With Type 1 Diabetes. / Wendt, Sabrina Lyngbye; Ranjan, Ajenthen; Møller, Jan Kloppenborg; Schmidt, Signe; Knudsen, Carsten Boye; Holst, Jens Juul; Madsbad, Sten; Madsen, Henrik; Nørgaard, Kirsten; Jørgensen, John Bagterp.

    In: Journal of Diabetes Science and Technology, Vol. 11, No. 6, 01.11.2017, p. 1101-1111.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Role of Glucagon in Catabolism and Muscle Wasting of Critical Illness and Modulation by Nutrition. / Thiessen, Steven E; Derde, Sarah; Derese, Inge; Dufour, Thomas; Vega, Chloé Albert; Langouche, Lies; Goossens, Chloë; Peersman, Nele; Vermeersch, Pieter; Vander Perre, Sarah; Holst, Jens J; Wouters, Pieter J; Vanhorebeek, Ilse; Van den Berghe, Greet.

    In: American Journal of Respiratory and Critical Care Medicine, Vol. 196, No. 9, 01.11.2017, p. 1131-1143.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. / Albrechtsen, Nicolai J. Wewer; Kuhre, Rune E.; Hornburg, Daniel; Jensen, Christian Z.; Hornum, Mads; Dirksen, Carsten; Svane, Maria; Gasbjerg, Laerke S.; Jorgensen, Nils B.; Gabe, Maria N.; Balk-Moller, Emilie; Albrechtsen, Reidar; Winther-Sorensen, Marie; Galsgaard, Katrine D.; Meissner, Felix; Jorsal, Tina; Lund, Asger; Vilsboll, Tina; Eliasen, Rasmus; Bojsen-Moller, Kirstine N.; Idorn, Thomas; Deacon, Carolyn F.; Knop, Filip K.; Rosenkilde, Mette M.; Hartmann, Bolette; Feldt-Rasmussen, Bo; Mann, Matthias; Madsbad, Sten; Holst, Jens J.

    In: Cell Reports, Vol. 21, No. 6, 11.2017, p. 1452-1460.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues. / Ten Kulve, Jennifer S; Veltman, Dick J; Gerdes, Victor E A; van Bloemendaal, Liselotte; Barkhof, Frederik; Deacon, Carolyn F; Holst, Jens J; Drent, Madeleine L; Diamant, Michaela; IJzerman, Richard G.

    In: Diabetes Care, Vol. 40, No. 11, 11.2017, p. 1522-1529.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Single-Dose Metformin Enhances Bile Acid-Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes. / Brønden, Andreas; Albér, Anders; Rohde, Ulrich; Rehfeld, Jens F; Holst, Jens J; Vilsbøll, Tina; Knop, Filip K.

    In: The Journal of clinical endocrinology and metabolism, Vol. 102, No. 11, 11.2017, p. 4153-4162.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    TRPV1 : A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities? / Gram, Dorte X; Holst, Jens J; Szallasi, Arpad.

    In: Trends in Molecular Medicine, Vol. 23, No. 11, 11.2017, p. 1002-1013.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals. / Mumme, Lena; Breuer, Thomas G K; Rohrer, Stephan; Schenker, Nina; Menge, Björn A; Holst, Jens J; Nauck, Michael A; Meier, Juris J.

    In: Diabetes Care, Vol. 40, No. 10, 10.2017, p. 1314-1322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition. / Kootte, Ruud S.; Levin, Evgeni; Salojärvi, Jarkko; Smits, Loek P.; Hartstra, Annick V.; Udayappan, Shanti D.; Hermes, Gerben; Bouter, Kristien E.; Koopen, Annefleur M.; Holst, Jens J.; Knop, Filip K.; Blaak, Ellen E.; Zhao, Jing; Smidt, Hauke; Harms, Amy C.; Hankemeijer, Thomas; Bergman, Jacques J.G.H.M.; Romijn, Hans A.; Schaap, Frank G.; Olde Damink, Steven W.M.; Ackermans, Mariette T.; Dallinga-Thie, Geesje M.; Zoetendal, Erwin; de Vos, Willem M.; Serlie, Mireille J.; Stroes, Erik S.G.; Groen, Albert K.; Nieuwdorp, Max.

    In: Cell Metabolism, Vol. 26, No. 4, 10.2017, p. 611-619.e6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Mathematical Modelling of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 following Ingestion of Glucose. / Røge, Rikke M; Bagger, Jonatan I; Alskär, Oskar; Kristensen, Niels R; Klim, Søren; Holst, Jens J; Ingwersen, Steen H; Karlsson, Mats O; Knop, Filip K; Vilsbøll, Tina; Kjellsson, Maria C.

    In: Basic & Clinical Pharmacology & Toxicology, Vol. 121, No. 4, 10.2017, p. 290-297.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Short-term effects of a low carbohydrate diet on glycaemic variables and cardiovascular risk markers in patients with type 1 diabetes : A randomized open-label crossover trial. / Ranjan, Ajenthen; Schmidt, Signe; Damm-Frydenberg, Camilla; Holst, Jens Juul; Madsbad, Sten; Nørgaard, Kirsten.

    In: Diabetes, Obesity and Metabolism, Vol. 19, No. 10, 10.2017, p. 1479-1484.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Why is it so difficult to measure glucagon-like peptide-1 in a mouse? / Windeløv, Johanne A; Wewer Albrechtsen, Nicolai J; Kuhre, Rune E; Jepsen, Sara L; Hornburg, Daniel; Pedersen, Jens; Jensen, Elisa P; Galsgaard, Katrine D; Winther-Sørensen, Marie; Ørgaard, Anne; Deacon, Carolyn F; Mann, Matthias; Kissow, Hannelouise; Hartmann, Bolette; Holst, Jens J.

    In: Diabetologia, Vol. 60, No. 10, 10.2017, p. 2066-2075.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite. / Wewer Albrechtsen, Nicolai J; Asmar, Ali; Jensen, Frederik; Törang, Signe; Simonsen, Lene; Kuhre, Rune E; Asmar, Meena; Veedfald, Simon; Plamboeck, Astrid; Knop, Filip K; Vilsbøll, Tina; Madsbad, Sten; Nauck, Michael A; Deacon, Carolyn F; Bülow, Jens; Holst, Jens J; Hartmann, Bolette.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 313, No. 3, 01.09.2017, p. E284-E291.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese. / Martins, Catia; Aschehoug, Irina; Ludviksen, Marit; Holst, Jens; Finlayson, Graham; Wisloff, Ulrik; Morgan, Linda; King, Neil; Kulseng, Bård.

    In: Medicine and Science in Sports and Exercise, Vol. 49, No. 9, 09.2017, p. 1851-1858.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor. / Asmar, Meena; Asmar, Ali; Simonsen, Lene; Gasbjerg, Lærke Smidt; Sparre-Ulrich, Alexander Hovard; Rosenkilde, Mette Marie; Hartmann, Bolette; Dela, Flemming; Holst, Jens Juul; Bülow, Jens.

    In: Diabetes, Vol. 66, No. 9, 09.2017, p. 2363-2371.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice. / Ørgaard, Anne; Holst, Jens J.

    In: Diabetologia, Vol. 60, No. 9, 09.2017, p. 1731-1739.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Pancreatic and Intestinal Function Post Roux-en-Y Gastric Bypass Surgery for Obesity. / O'Keefe, Stephen J D; Rakitt, Tina; Ou, Junhai; El Hajj, Ihab I; Blaney, Elizabeth; Vipperla, Kishore; Holst, Jens-Jules; Rehlfeld, Jens.

    In: Clinical and Translational Gastroenterology, Vol. 8, e112, 03.08.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Glucose ingestion causes cardiac repolarization disturbances in type 1 long QT syndrome patients and healthy subjects. / Hyltén-Cavallius, Louise; Iepsen, Eva W; Christiansen, Michael; Graff, Claus; Linneberg, Allan; Pedersen, Oluf; Holst, Jens J; Hansen, Torben; Torekov, Signe S; Kanters, Jørgen K.

    In: Heart Rhythm, Vol. 14, No. 8, 08.2017, p. 1165-1170.

    Research output: Contribution to journalJournal articleResearchpeer-review

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