Jens Juul Holst

Jens Juul Holst

Professor


  1. 2010
  2. Published

    Treatment of insulin resistance and obesity by stimulating GLP-1 release. / Hansen, Harald S. (Inventor); Diep, Thi Ai (Inventor); Holst, Jens Juul (Inventor); Rosenkilde, Mette Marie (Inventor); Andersen, Niels Wellner (Inventor).

    IPC No.: A61K 31/23. Patent No.: PCT/DK2010/050161. Jun 24, 2010.

    Research output: PatentResearch

  3. Published

    Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1. / Migoya, E M; Bergeron, R; Miller, J L; Snyder, R N K; Tanen, M; Hilliard, D; Weiss, B; Larson, P; Gutierrez, M; Jiang, G; Liu, F.; Pryor, K A; Yao, J; Zhu, L; Holst, Jens Juul; Deacon, C; Herman, G; Thornberry, N; Amatruda, J; Williams-Herman, D; Wagner, J A; SinhaRoy, R.

    In: Clinical Pharmacology and Therapeutics, Vol. 88, No. 6, 01.12.2010, p. 801-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure. / Koopmann, Matthew C; Chen, Xueyan; Holst, Jens Juul; Ney, Denise M.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 299, No. 6, 01.12.2010, p. G1222-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning. / Nilsson, Anne C; Östman, Elin M; Knudsen, Knud Erik Bach; Holst, Jens Juul; Björck, Inger M E.

    In: Journal of Nutrition, Vol. 140, No. 11, 01.11.2010, p. 1932-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis. / Edholm, T; Degerblad, M; Grybäck, P; Hilsted, L; Holst, Jens Juul; Jacobsson, H; Efendic, S; Schmidt, P T; Hellström, P M.

    In: Neurogastroenterology and Motility Online, Vol. 22, No. 11, 01.11.2010, p. 1191-200, e315.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Kardiale virkninger af glukagonlignende peptid 1. / Holst, Jens Juul.

    In: Ugeskrift for Laeger, Vol. 172, No. 41, 11.10.2010, p. 2821.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Expression of mRNA for proglucagon and glucagon-like peptide-2 (GLP-2) receptor in the ruminant gastrointestinal tract and the influence of energy intake. / Taylor-Edwards, C C; Burrin, D G; Matthews, J C; McLeod, K R; Holst, Jens Juul; Harmon, D L.

    In: Domestic Animal Endocrinology, Vol. 39, No. 3, 01.10.2010, p. 181-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The intestinotrophic peptide, GLP-2, counteracts the gastrointestinal atrophy in mice induced by the epidermal growth factor receptor inhibitor, erlotinib, and cisplatin. / Rasmussen, Andreas Rosén; Viby, Niels-Erik; Hare, Kristine Juul; Hartmann, Bolette; Thim, Lars; Holst, Jens Juul; Poulsen, Steen Seier.

    In: Digestive Diseases and Sciences, Vol. 55, No. 10, 01.10.2010, p. 2785-96.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Glucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis. / Knop, F K; Vilsbøll, T; Larsen, Steen; Madsbad, S; Holst, Jens Juul; Krarup, Troels Magelund.

    In: Regulatory Peptides, Vol. 164, No. 2-3, 24.09.2010, p. 144-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The impact of pancreatic enzyme supplementation on postprandial responses of glucagon-like Peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency. / Knop, Filip K; Vilsbøll, Tina; Lund, Asger; Krarup, Thure; Holst, Jens Juul; Hornum, Mads.

    In: Journal of the Pancreas, Vol. 11, No. 5, 06.09.2010, p. 489-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans. / Asmar, Meena; Simonsen, Lene; Madsbad, Sten; Stallknecht, Bente Merete; Holst, Jens Juul; Bülow, Jens.

    In: Diabetes, Vol. 59, No. 9, 01.09.2010, p. 2160-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes. / Christensen, Mikkel; Knop, Filip K; Vilsbøll, Tina; Aaboe, Kasper; Holst, Jens Juul; Madsbad, Sten; Krarup, Thure.

    In: Regulatory Peptides, Vol. 163, No. 1-3, 09.08.2010, p. 96-101.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Dipeptidyl peptidase expression during experimental colitis in mice. / Yazbeck, Roger; Sulda, Melanie L; Howarth, Gordon S; Bleich, Andre; Raber, Kerstin; von Hörsten, Stephan; Holst, Jens Juul; Abbott, Catherine A.

    In: Inflammatory Bowel Diseases, Vol. 16, No. 8, 01.08.2010, p. 1340-1351.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans. / Meier, Juris J; Ritter, Peter R; Jacob, Alexandra; Menge, Bjoern A; Deacon, Carolyn F; Schmidt, Wolfgang E; Nauck, Michael A; Holst, Jens J.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 8, 01.08.2010, p. 4061-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men. / Lapauw, Bruno; Ouwens, Margriet; 't Hart, Leen M; Wuyts, Birgitte; Holst, Jens Juul; T'Sjoen, Guy; Kaufman, Jean-Marc; Ruige, Johannes B.

    In: Diabetes Care, Vol. 33, No. 8, 01.08.2010, p. 1831-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects. / Hansen, K B; Vilsbøll, T; Bagger, J I; Holst, Jens Juul; Knop, F K.

    In: The Journal of clinical endocrinology and metabolism, Vol. 95, No. 7, 01.07.2010, p. 3309-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. / Hare, Kristine J; Vilsbøll, Tina; Asmar, Meena; Deacon, Carolyn F; Knop, Filip K; Holst, Jens Juul.

    In: Diabetes, Vol. 59, No. 7, 01.07.2010, p. 1765-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans. / Falkén, Y; Hellström, P M; Sanger, G J; Dewit, O; Dukes, G; Grybäck, P; Holst, Jens Juul; Näslund, E.

    In: Neurogastroenterology and Motility, Vol. 22, No. 6, 01.06.2010, p. e192-200.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Effect of growth in infancy on body composition, insulin resistance, and concentration of appetite hormones in adolescence. / Larnkjaer, Anni; Schack-Nielsen, Lene; Mølgaard, Christian; Ingstrup, Helga K; Holst, Jens Juul; Michaelsen, Kim F.

    In: American Journal of Clinical Nutrition, Vol. 91, No. 6, 01.06.2010, p. 1675-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans? / Asmar, Meena; Bache, Michael; Knop, Filip K; Madsbad, Sten; Holst, Jens Juul.

    In: The Journal of clinical endocrinology and metabolism, Vol. 95, No. 5, 01.05.2010, p. 2367-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The influence of nutrients, biliary-pancreatic secretions, and systemic trophic hormones on intestinal adaptation in a Roux-en-Y bypass model. / Taqi, Esmaeel; Wallace, Laurie E; de Heuvel, Elaine; Chelikani, Prasanth K; Zheng, Huiyuan; Berthoud, Hans-Rudolph; Holst, Jens Juul; Sigalet, David L.

    In: European Journal of Pediatric Surgery. Supplement, Vol. 45, No. 5, 01.05.2010, p. 987-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese : Comparison of type 2 diabetes patients and healthy controls. / Yabe, Daisuke; Kuroe, Akira; Lee, Soushou; Watanabe, Koin; Hyo, Takanori; Hishizawa, Masahiro; Kurose, Takeshi; Deacon, Carolyn F; Holst, Jens Juul; Hirano, Tsutomu; Inagaki, Nobuya; Seino, Yutaka.

    In: Journal of Diabetes Investigation, Vol. 1, No. 1-2, 22.04.2010, p. 56-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Automated detection of hypoglycemia-induced EEG changes recorded by subcutaneous electrodes in subjects with type 1 diabetes--the brain as a biosensor. / Juhl, Claus B. ; Højlund, Kurt; Elsborg, Rasmus ; Poulsen, Mikael Kjaer; Selmar, Peter E; Holst, Jens Juul; Christiansen, Claus; Beck-Nielsen, Henning.

    In: Diabetes Research and Clinical Practice, Vol. 88, No. 1, 01.04.2010, p. 22-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes. / Hare, Kristine J; Vilsbøll, Tina; Holst, Jens Juul; Knop, Filip K.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 298, No. 4, 01.04.2010, p. E832-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat. / Martins, Cecilia; Kulseng, B; King, N A; Holst, Jens Juul; Blundell, J E.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 4, 01.04.2010, p. 1609-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus. / Aaboe, K; Knop, F K; Vilsbøll, T; Deacon, C F; Holst, Jens Juul; Madsbad, S; Krarup, Troels Magelund.

    In: Diabetes, Obesity and Metabolism, Vol. 12, No. 4, 01.04.2010, p. 323-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery. / McLaughlin, Tracey; Peck, Marcia; Holst, Jens; Deacon, Carolyn.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 4, 04.2010, p. 1851-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes. / Kozawa, Junji; Okita, Kohei; Imagawa, Akihisa; Iwahashi, Hiromi; Holst, Jens Juul; Yamagata, Kazuya; Shimomura, Iichiro.

    In: Biochemical and Biophysical Research Communications, Vol. 393, No. 3, 12.03.2010, p. 410-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure. / Halbirk, Mads; Nørrelund, Helene; Møller, Niels; Holst, Jens Juul; Schmitz, Ole; Nielsen, Bent Roni Ranghøj; Nielsen-Kudsk, Jens Erik; Nielsen, Søren Steen; Nielsen, Torsten Toftegaard; Eiskjaer, Hans; Bøtker, Hans Erik; Wiggers, Henrik.

    In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 298, No. 3, 01.03.2010, p. H1096-H1102.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: new advances. / Asmar, Meena; Holst, Jens Juul.

    In: Current Opinion in Endocrinology, Diabetes and Obesity, Vol. 17, No. 1, 01.02.2010, p. 57-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion : a case report. / Dirksen, Carsten; Hansen, Dorte L; Madsbad, Sten; Hvolris, Lisbeth E; Naver, Lars S; Holst, Jens Juul; Worm, Dorte.

    In: Diabetes Care, Vol. 33, No. 2, 02.2010, p. 375-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The effect of glucagon-like peptide-2 on arterial blood flow and cardiac parameters. / Bremholm, Lasse; Hornum, Mads; Andersen, Ulrik B; Holst, Jens Juul.

    In: Regulatory Peptides, Vol. 159, No. 1-3, 08.01.2010, p. 67-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes. / Lodefalk, M; Carlsson-Skwirut, C; Holst, Jens Juul; Aman, J; Bang, P.

    In: Hormone research in pædiatrics, Vol. 73, No. 5, 01.01.2010, p. 355-362.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Glucagon and glucagon-like peptides 1 and 2. / Holst, Jens Juul.

    In: Results and Problems in Cell Differentiation, Vol. 50, 01.01.2010, p. 121-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The effect of glucagon-like Peptide-2 receptor agonists on colonic anastomotic wound healing. / Redstone, Heather A; Buie, William D; Hart, David A; Wallace, Laurie; Hornby, Pamela J; Sague, Sarah; Holst, Jens Juul; Sigalet, David L.

    In: Gastroenterology Research and Practice, Vol. 2010, 01.01.2010, p. Article ID 672453.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes. / Deacon, Carolyn F; Holst, Jens Juul.

    In: Expert Opinion on Investigational Drugs, Vol. 19, No. 1, 01.2010, p. 133-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls. / Yabe, D; Kuroe, A; Lee, S; Watanabe, K; Hyo, T; Hishizawa, M; Kurose, T; Deacon, Carolyn F.; Holst, Jens Juul; Hirano, T; Inagaki, N; Seino, Y.

    In: Journal of Diabetes Investigation, Vol. 1, No. 1/2, 01.2010, p. 56-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects. / Brader, Lea Johanne; Holm, L.; Mortensen, L.; Thomsen, C.; Astrup, Arne; Holst, Jens Juul; Vrese, M. de; Schrezenmeir, J.; Hermansen, Kjeld.

    In: Nutrition, Metabolism & Cardiovascular Diseases, Vol. 20, No. 2, 2010, p. 101-109.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Effect of glucagon-like peptide-1 on alpha- and beta-cell function in C-peptide-negative type 1 diabetic patients. / Kielgast, Urd; Asmar, Meena; Madsbad, Sten; Holst, Jens Juul.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 5, 2010, p. 2492-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Increased Postprandial Response of Glucagon-Like Peptide-2 in Patients with Chronic Pancreatitis and Pancreatic Exocrine Insufficiency. / Hornum, Mads; Pedersen, Jan F; Larsen, Steen; Olsen, Ole; Holst, Jens J; Knop, Filip K.

    In: Pancreatology, Vol. 10, No. 2-3, 2010, p. 201-207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes. / Deacon, Carolyn F.; Holst, Jens Juul.

    In: Expert Opinion on Investigational Drugs, Vol. 19, No. 1, 2010, p. 133-140.

    Research output: Contribution to journalReviewResearchpeer-review

  43. Published

    On the role of glucose-dependent insulintropic polypeptide in postprandial metabolism in humans. / Asmar, Meena; Tangaa, Winnie; Madsbad, Sten; Hare, Kristine; Astrup, Arne; Flint, Anne; Bülow, Jens; Holst, Jens Juul.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 298, No. 3, 2010, p. E614-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Pancreatic beta-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes. / Asmar, Meena; Højberg, Patricia V; Deacon, Carolyn F; Hare, Kristine; Holst, Jens Juul; Madsbad, Sten.

    In: Regulatory Peptides, Vol. 160, No. 1-3, 2010, p. 175-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Pancreatic ß-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes. / Asmar, Meena; Højberg, Patricia; Deacon, Carolyn F.; Hare, Kristine; Holst, Jens Juul; Madsbad, Sten.

    In: Regulatory Peptides, Vol. 160, No. 1-3, 2010, p. 175-180.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report. / Dirksen, Carsten; Hansen, Dorte L; Madsbad, Sten; Hvolris, Lisbeth E; Naver, Lars S; Holst, Jens J; Worm, Dorte; Dirksen, Carsten; Hansen, Dorte L; Madsbad, Sten; Hvolris, Lisbeth E; Naver, Lars S; Holst, Jens J; Worm, Dorte.

    In: Diabetes Care, Vol. 33, No. 2, 2010, p. 375-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men. / Carr, Richard D; Larsen, Marianne O; Jelic, Katarina; Lindgren, Ola; Vikman, Jenny; Holst, Jens J; Deacon, Carolyn F; Ahrén, Bo.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 2, 2010, p. 872-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. / Alibegovic, Amra C; Sonne, Mette P; Højbjerre, Lise; Hansen, Torben; Pedersen, Oluf; van Hall, Gerrit; Holst, Jens J; Stallknecht, Bente; Dela, Flemming; Vaag, Allan.

    In: Diabetes, Vol. 59, No. 4, 2010, p. 836-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose. / Bock, Gerlies; Man, Chiara Dalla; Micheletto, Francesco; Basu, Rita; Rn, Paula D Giesler; Laugen, Jeanette; Deacon, Carolyn F; Holst, Jens J; Toffolo, Gianna; Cobelli, Claudio; Rizza, Robert A; Vella, Adrian.

    In: Clinical Endocrinology, Vol. 73, 2010, p. 189-196.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

ID: 4207