Jens Juul Holst

Jens Juul Holst

Professor


  1. Published

    Post-surgical effects of Roux-En-Y gastric bypass on glucose homeostasis, intestinal morphology and L-cells in obese Göttingen minipigs. / Barkholt, Pernille; Vegge, Andreas; Clausen, Trine Ryberg; Birck, Malene Muusfeldt; Fels, Johannes Josef; Støckel, Mikael; Gögenür, Ismayil; Eriksen, Thomas; Holst, Jens Juul; Hansen, Axel Kornerup; Thymann, Thomas; Jelsing, Jacob; Sangild, Per Torp; Raun, Kirsten.

    In: Journal of Obesity and Bariatrics, Vol. 1, No. 1, 2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    In vivo efficacy of HD0471953 : A novel GPR119 agonist for the treatment of type 2 diabetes mellitus. / 'T Hart, L. M.; Fritsche, A.; Nijpels, G.; Van Leeuwen, N.; Donnelly, L. A.; Dekker, J. M.; Alssema, M.; Fadista, J.; Carlotti, F.; Gjesing, A. P.; Palmer, C. N.; Van Haeften, T. W.; Herzberg-Schäfer, S. A.; Simonis-Bik, A. M.; Houwing-Duistermaat, J. J.; Helmer, Q.; Deelen, J.; Guigas, B.; Hansen, T.; MacHicao, F.; Willemsen, G.; Heine, R. J.; Kramer, M. H.; Holst, J. J.; De Koning, E. J.; Häring, H. U.; Pedersen, O.; Groop, L.; De Geus, E. J.; Slagboom, P. E.; Boomsma, D. I.; Eekhoff, E. M.; Pearson, E. R.; Diamant, M.

    In: Diabetes Technology & Therapeutics, Vol. 17, 01.02.2015, p. S131-S133.

    Research output: Contribution to journalComment/debateResearchpeer-review

  3. Published

    The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway. / 't Hart, Leen M; Fritsche, Andreas; Nijpels, Giel; van Leeuwen, Nienke; Donnelly, Louise A; Dekker, Jacqueline M; Alssema, Marjan; Fadista, Joao; Carlotti, Françoise; Gjesing, Anette P; Palmer, Colin N A; van Haeften, Timon W; Herzberg-Schäfer, Silke A; Simonis-Bik, Annemarie M C; Houwing-Duistermaat, Jeanine J; Helmer, Quinta; Deelen, Joris; Guigas, Bruno; Hansen, Torben; Machicao, Fausto; Willemsen, Gonneke; Heine, Robert J; Kramer, Mark; Holst, Jens Juul; de Koning, Eelco J P; Häring, Hans-Ulrich; Pedersen, Oluf; Groop, Leif; de Geus, Eco J C; Slagboom, P Eline; Boomsma, Dorret I; Eekhoff, Elisabeth M W; Pearson, Ewan R; Diamant, Michaela.

    In: Diabetes, Vol. 62, No. 9, 14.05.2013, p. 3275-3281.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus. / Aaboe, K; Knop, F K; Vilsbøll, T; Deacon, C F; Holst, Jens Juul; Madsbad, S; Krarup, Troels Magelund.

    In: Diabetes, Obesity and Metabolism, Vol. 12, No. 4, 01.04.2010, p. 323-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors. / Aaboe, K.; Akram, S.; Deacon, C. F.; Holst, J. J.; Madsbad, S.; Krarup, T.

    In: Diabetes, Obesity and Metabolism, Vol. 17, No. 1, 01.2015, p. 74-81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published
  7. Published

    GLP-1: physiological effects and potential therapeutic applications. / Aaboe, Kasper; Krarup, Thure; Madsbad, Sten; Holst, Jens Juul; Aaboe, Kasper; Krarup, Thure; Madsbad, Sten; Holst, Jens Juul.

    In: Diabetic Medicine, Vol. 10, No. 11, 2008, p. 994-1003.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    GLP-1 : physiological effects and potential therapeutic applications. / Aaboe, Kasper; Krarup, Thure; Madsbad, Sten; Holst, Jens Juul.

    In: Diabetes, Obesity and Metabolism Online, Vol. 10, No. 11, 11.2008, p. 994-1003.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide (GIP) in patients with type 2 diabetes. / Aaboe, Kasper; Knop, Filip Krag; Vilsbøll, Tina; Vølund, A; Simonsen, U; Deacon, Carolyn F.; Madsbad, Sten; Holst, Jens Juul; Krarup, Thure.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 2, 2009, p. 603-608.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. / Aaboe, Kasper; Knop, Filip Krag; Vilsboll, Tina; Vølund, Aage; Simonsen, Ulf; Deacon, Carolyn F.; Madsbad, Sten; Holst, Jens Juul; Krarup, Thure.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 2, 2008, p. 603-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published
  12. Published

    Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. / Adriaenssens, Alice E; Svendsen, Berit; Lam, Brian Y H; Yeo, Giles S H; Holst, Jens J; Reimann, Frank; Gribble, Fiona M.

    In: Diabetologia, Vol. 59, No. 10, 10.2016, p. 2156-2165.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Characterization of GLP-1 effects on beta cell function after meal ingestion in humans. / Ahren, B.; Holst, Jens Juul; Mari, A.

    In: Diabetes Care, No. 26, 2003, p. 2860-2864.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients : No Significant Differences in Biomarkers, Including Plasma Phe Levels. / Ahring, Kirsten K.; Lund, Allan M.; Jensen, Erik; Jensen, Thomas G.; Brondum-Nielsen, Karen; Pedersen, Michael; Bardow, Allan; Holst, Jens Juul; Rehfeld, Jens F.; Moller, Lisbeth B.

    In: Journal of Nutrition and Metabolism, Vol. 2018, 6352919, 2018, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Anti-diabetogenic effect of the human amylin analogue, pramlintide, in Type 1 diabetes is not mediated by GLP-1. / Ahrén, B; Adner, N; Svartberg, J; Petrella, E; Holst, Jens Juul; Gutniak, M K.

    In: Diabetic Medicine, Vol. 19, No. 9, 09.2002, p. 790-2.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    GIP and GLP-1 after oral glucose in postmenopausal women with impaired glucose tolerance. / Ahrén, Bo; Larsson, H.; Holst, Jens Juul.

    In: European Journal of Endocrinology, No. 137, 1997, p. 127-131.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Antidiabetogenic action of cholecystokinin in type 2 diabetes. / Ahrén, Bo; Holst, J.J.; Efendic, S.

    In: J. Clin. Endocrinol. Metab., No. 85, 2000, p. 1043-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. / Ahrén, Bo; Holst, J.J.

    In: Diabetes, No. 50, 2001, p. 1030-1038.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans. / Ahrén, Bo; Holst, Jens Juul; Mari, Andrea.

    In: Diabetes Care. Supplement, Vol. 26, No. 10, 10.2003, p. 2860-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in non-insulin dependent diabetes mellitus. / Ahrén, Bo; Larsson, H.; Holst, Jens Juul.

    In: J. Clin. Endocrinol. Metab., No. 82, 1997, p. 473-478.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    1,5-Anhydro fructose increase glucose tolerance by increasing GLP-1 and insulin in mice. / Ahrén, Bo; Holst, J.J.; Marcussen, J.; Yu, S.

    In: Eur. J. Pharmacol., No. 397, 2000, p. 219-225.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Improved glucagon tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice. / Ahrén, Bo; Holst, J.J.; Mårtensson, H.; Balkan, B.

    In: Eur. J. Pharmacol., No. 404, 2000, p. 239-245.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. / Albrechtsen, Nicolai J. Wewer; Kuhre, Rune E.; Hornburg, Daniel; Jensen, Christian Z.; Hornum, Mads; Dirksen, Carsten; Svane, Maria; Gasbjerg, Laerke S.; Jorgensen, Nils B.; Gabe, Maria N.; Balk-Moller, Emilie; Albrechtsen, Reidar; Winther-Sorensen, Marie; Galsgaard, Katrine D.; Meissner, Felix; Jorsal, Tina; Lund, Asger; Vilsboll, Tina; Eliasen, Rasmus; Bojsen-Moller, Kirstine N.; Idorn, Thomas; Deacon, Carolyn F.; Knop, Filip K.; Rosenkilde, Mette M.; Hartmann, Bolette; Feldt-Rasmussen, Bo; Mann, Matthias; Madsbad, Sten; Holst, Jens J.

    In: Cell Reports, Vol. 21, No. 6, 11.2017, p. 1452-1460.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Hyperglucagonaemia analysed by glucagon sandwich ELISA : nonspecific interference or truly elevated levels? / Albrechtsen, Nicolai Jacob Wewer; Hartmann, Bolette; Veedfald, Simon; Windeløv, Johanne A; Plamboeck, Astrid; Bojsen-Møller, Kirstine N; Idorn, Thomas; Feldt-Rasmussen, Bo; Knop, Filip K; Vilsbøll, Tina; Madsbad, Sten; Deacon, Carolyn F; Holst, Jens J.

    In: Diabetologia, Vol. 57, No. 9, 03.06.2014, p. 1919-1926.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Targeting the intestinal L-cell for obesity and type 2 diabetes treatment. / Albrechtsen, Nicolai Jacob Wewer; Kuhre, Rune Ehrenreich; Deacon, Carolyn F.; Holst, Jens Juul.

    In: Expert Review of Endocrinology & Metabolism, Vol. 9, No. 1, 01.01.2014, p. 61-72.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes. / Albrechtsen, Nicolai Jacob Wewer; Kuhre, Rune Ehrenreich; Windeløv, Johanne Agerlin; Ørgaard, Anne; Deacon, Carolyn F.; Kissow, Hannelouise; Hartmann, Bolette; Holst, Jens Juul.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 311, No. 2, 2016, p. E302-E309.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published
  28. Published

    The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs. / Albrechtsen, Nicolai Jacob Wewer; Kuhre, Rune Ehrenreich; Toräng, Signe; Holst, Jens Juul.

    In: BMC Research Notes, Vol. 9, No. 1, 60, 02.02.2016, p. 1-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Stability of glucagon-like peptide-1 and glucagon in human plasma. / Albrechtsen, Nicolai Jacob Wewer; Bak, Monika Judyta; Hartmann, Bolette; Christensen, Louise Wulff; Kuhre, Rune E; Deacon, Carolyn; Holst, Jens Juul.

    In: Endocrine Connections, Vol. 4, No. 1, 16.01.2015, p. 50-57.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. / Alibegovic, Amra C; Sonne, Mette P; Højbjerre, Lise; Hansen, Torben; Pedersen, Oluf; van Hall, Gerrit; Holst, Jens J; Stallknecht, Bente; Dela, Flemming; Vaag, Allan.

    In: Diabetes, Vol. 59, No. 4, 2010, p. 836-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Glucagon immunoneutralization in diabetic rats normalizes urea synthesis and decreases nitrogen wasting. / Almdal, Thomas Peter; Holst, Jens Juul; Vilstrup, H.

    In: Diabetes, No. 41, 1992, p. 12-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Genetic determinants of circulating GIP and GLP-1 concentrations. / Almgren, Peter; Lindqvist, Andreas; Krus, Ulrika; Hakaste, Liisa; Ottosson-Laakso, Emilia; Asplund, Olof; Sonestedt, Emily; Prasad, Rashmi B; Laurila, Esa; Orho-Melander, Marju; Melander, Olle; Tuomi, Tiinamaija; Holst, Jens Juul; Nilsson, Peter M; Wierup, Nils; Groop, Leif; Ahlqvist, Emma.

    In: JCI insight, Vol. 2, No. 21, e93306, 02.11.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in CHL cells. / Almind, K.; Ambye, Louise; Urhammer, S.A.; Hansen, T.; Echwald, S.M.; Holst, J.J.; Gromada, Jesper Lindgren; Thorens, B.; Pedersen, O.

    In: Diabetologia, No. 41, 1998, p. 1194-1198.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT. / Alssema, Marjan; Rijkelijkhuizen, Josina M; Holst, Jens Juul; Teerlink, Tom; Scheffer, Peter G; Eekhoff, Elisabeth M W; Gastaldelli, Amalia; Mari, Andrea; Hart, Leen M't; Nijpels, Giel; Dekker, Jacqueline M.

    In: European Journal of Endocrinology, Vol. 169, No. 4, 10.2013, p. 421-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate. / Amin, H.; Holst, Jens Juul; Hartmann, B.; Wallace, L.; Wright, J.; Sigalet, D.L.

    In: Pediatrics, Vol. 121, No. 1, 2008, p. E180-E186.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate. / Amin, Harish; Holst, Jens Juul; Hartmann, Bolette; Wallace, Laurie; Wright, Jim; Sigalet, David L.

    In: Pediatrics, Vol. 121, No. 1, 01.2008, p. e180-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes? / Andersen, Emilie S.; Lund, A.; Bagger, J. I.; Andreasen, C; Grøndahl, MF; Deacon, Carolyn F.; Hartmann, Bolette; Holst, Jens Juul; Knop, Filip Krag; Lauritsen, Tina Vilsbøll.

    In: Diabetes, Obesity and Metabolism, Vol. 20, No. 8, 08.2018, p. 1937-1943.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Do we know the true mechanism of action of the DPP-4 inhibitors? / Andersen, Emilie S.; Deacon, Carolyn F.; Holst, Jens Juul.

    In: Diabetes, Obesity and Metabolism, Vol. 20, No. 1, 2018, p. 34-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy. / Andersen, O; Haugaard, S B; Holst, Jens Juul; Deacon, C F; Iversen, J; Andersen, U B; Nielsen, J O; Madsbad, S.

    In: HIV Medicine, Vol. 6, No. 2, 03.2005, p. 91-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Enhanced glucagon-like peptide- 1 (GLP-1) response to oral glucose in glucose intolerant HIV-infected patients on antiretroviral therapy. / Andersen, O.; Haugaard, S.B.; Holst, Jens Juul; Deacon, Carolyn F.; Iversen, J.; Andersen, U.B.; Nielsen, J.O.; Madsbad, S.

    In: HIV Medicine, Vol. 6, 2005, p. 91-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Secretion of glucagon-like peptide-1 and reactive hypoglycemia after partial gastrectomy. / Andreasen, J.; Ørskov, Cathrine; Holst, Jens Juul.

    In: Digestion, No. 55, 1994, p. 221-228.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Glucagon-like peptide-2 (GLP-2) response to enteral intake in children during anti-cancer treatment. / Andreassen, B U; Paerregaard, A; Schmiegelow, K; Rechnitzer, C; Heilman, C; Hartmann, B; Holst, Jens Juul; Michaelsen, K F.

    In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 40, No. 1, 01.2005, p. 48-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Glucagon-like-peptide-2 (GLP-2) response to enteral intake in children during anticancer treatment. / Andreassen, B.U.; Pærregaard, A.; Schmiegelow, K.; Rechnitzer, C.; Hartmann, Bolette; Holst, Jens Juul; Michaelsen, K.F.

    In: Journal of Pediatric Gastroenterology and Nutrition, No. 40, 2005, p. 48-53.

    Research output: Contribution to journalJournal articleResearch

  44. Published

    Liraglutide improves the beta-cell function without increasing insulin secretion during a mixed meal in patients, who exhibit well-controlled type 2 diabetes and coronary artery disease. / Anholm, Christian; Kumarathurai, Preman; Jurs, Anders; Pedersen, Lene Rorholm; Nielsen, Olav Wendelboe; Kristiansen, Ole Peter; Fenger, Mogens; Holst, Jens Juul; Madsbad, Sten; Sajadieh, Ahmad; Haugaard, Steen Bendix.

    In: Diabetology & Metabolic Syndrome, Vol. 11, 42, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects : a possible link between obesity and local tissue inflammation? / Arngrim, N; Simonsen, L; Holst, Jens Juul; Bülow, J.

    In: International Journal of Obesity, Vol. 37, 2012, p. 748-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Effect of glucagon-like peptide-2 exposure on bone resorption : Effectiveness of high concentration versus prolonged exposure. / Askov-Hansen, Carsten; Jeppesen, Palle B; Lund, Pernille; Hartmann, Bolette; Holst, Jens Juul; Henriksen, Dennis B.

    In: Regulatory Peptides, Vol. 181, 10.02.2013, p. 4-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1 : A Functional GLP-1–Renal Axis in Man. / Asmar, Ali; Cramon, Per K; Simonsen, Lene; Asmar, Meena; Sorensen, Charlotte M; Madsbad, Sten; Moro, Cedric; Hartmann, Bolette; Jensen, Boye L; Holst, Jens J; Bülow, Jens.

    In: The Journal of clinical endocrinology and metabolism, Vol. 104, No. 7, 07.2019, p. 2509–2519.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Glucagon-like peptide-1 does not have acute effects on central or renal hemodynamics in patients with type 2 diabetes without nephropathy. / Asmar, Ali; Simonsen, Lene; Asmar, Meena; Madsbad, Sten; Holst, Jens J; Frandsen, Erik; Moro, Cedric; Sorensen, Charlotte M; Jonassen, Thomas; Bulow, Jens.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 310, No. 9, 05.2016, p. E744-E753.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Renal Extraction and Acute Effects of Glucagon-like peptide-1 on Central and Renal Hemodynamics in Healthy Men. / Asmar, Ali; Simonsen, Lene; Asmar, Meena; Madsbad, Sten; Holst, Jens Juul; Frandsen, Erik; Moro, Cedric; Jonassen, Thomas; Bülow, Jens.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 308, No. 8, 15.04.2015, p. E641-E649.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men. / Asmar, Ali; Asmar, Meena; Simonsen, Lene; Madsbad, Sten; Holst, Jens J; Hartmann, Bolette; Sorensen, Charlotte M; Bülow, Jens.

    In: Physiological Reports, Vol. 5, No. 3, e13073, 02.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

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