Jens Juul Holst

Jens Juul Holst

Professor


  1. 2002
  2. Published

    Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. / Holst, Jens Juul.

    In: Diabetes - Metabolism: Research and Reviews (Print Edition), Vol. 18, No. 6, 2002, p. 430-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight. / Jensen, Christine B; Storgaard, Heidi; Dela, Flemming; Holst, Jens Juul; Madsbad, Sten; Vaag, Allan A.

    In: Diabetes, Vol. 51, No. 4, 2002, p. 1271-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Abnormal release of incretins and cortisol after oral glucose in subjects with insulin-resistant myotonic dystrophy. / Johansson, Asa; Olsson, Tommy; Cederquist, Kristina; Forsberg, Hakan; Holst, Jens Juul; Seckl, Jonathan R; Ahren, Bo.

    In: European Journal of Endocrinology. Supplement, Vol. 146, No. 3, 03.2002, p. 397-405.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Abnormal release of incretins and cortisol after oral glucose in insulin resistant myotonic dystrophy. / Johansson, Å.; Olsson, T.; Cederquist, K.; Forsberg, H.; Holst, J.J.; Seckl, J.R.; Ahrén, Bo.

    In: European Journal of Endocrinology, No. 146, 2002, p. 397-405.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Postprandial glucose, insulin and incretin responses to grain products in healthy subjects. / Juntunen, K.S.; Lioukkonen, H.K.; Poutanen, S.K.; Niskanen, K.L.; Holst, J.J.; Mykkänen, M.H.

    In: Am. J. Clin. Nutr., No. 75, 2002, p. 254-262.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Repaglinide at a cellular level. / Krogsgaard Thomsen, M; Bokvist, K; Høy, M; Buschard, K; Holst, Jens Juul; Lindström, P; Gromada, J.

    In: Diabetes, nutrition & metabolism, Vol. 15, No. 6 Suppl, 12.2002, p. 15-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Inhibition of gastric inhibitory polypeptide signaling prevents obesity. / Miyawaki, Kazumasa; Yamada, Yuichiro; Ban, Nobuhiro; Ihara, Yu; Tsukiyama, Katsushi; Zhou, Heying; Fujimoto, Shimpei; Oku, Akira; Tsuda, Kinsuke; Toyokuni, Shinya; Hiai, Hiroshi; Mizunoya, Wataru; Fushiki, Tohru; Holst, Jens Juul; Makino, Mitsuhiro; Tashita, Akira; Kobara, Yukari; Tsubamoto, Yoshiharu; Jinnouchi, Takayoshi; Jomori, Takahito; Seino, Yutaka.

    In: Nature Medicine, Vol. 8, No. 7, 2002, p. 738-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Effects of glucagon-like peptide-1 (GLP-1) on counterregulatory hormone responses, cognitive functions and insulin secretion during hyperinsulinaemic, stepped hypoglycaemic clamp experiments in healthy volunteers. / Nauck, M.A.; Heimesaat, M.M.; Behle, K.; Holst, J.J.; Nauck, M.S.; Hüfner, M.; Schmiegel, W.H.

    In: J. Clin. Endocrinol. Metab., No. 87, 2002, p. 1239-1246.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. / Nauck, Michael A; Heimesaat, Markus M; Behle, Kai; Holst, Jens Juul; Nauck, Markus S; Ritzel, Robert; Hüfner, Michael; Schmiegel, Wolff H.

    In: The Journal of clinical endocrinology and metabolism, Vol. 87, No. 3, 03.2002, p. 1239-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. / Reimer, M Kvist; Holst, Jens Juul; Ahrén, B.

    In: European Journal of Endocrinology. Supplement, Vol. 146, No. 5, 05.2002, p. 717-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. / Reimer, M.K.; Holst, J.J.; Ahrén, Bo.

    In: European Journal of Endocrinology, No. 146, 2002, p. 717-727.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist. / Thulesen, Jesper; Knudsen, Lotte Bjerre; Hartmann, Bolette; Hastrup, Sven; Kissow, Hannelouise; Jeppesen, Palle Bekker; Ørskov, Cathrine; Holst, Jens Juul; Poulsen, Steen Seier.

    In: Regulatory Peptides, Vol. 103, No. 1, 2002, p. 9-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. / Zander, Mette; Madsbad, Sten; Madsen, Jan Lysgaard; Holst, Jens Juul.

    In: Lancet, Vol. 359, No. 9309, 2002, p. 824-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. / Zhu, Xiaorong; Zhou, An; Dey, Arunangsu; Norrbom, Christina; Carroll, Raymond; Zhang, Chunling; Laurent, Virginie; Lindberg, Iris; Ugleholdt, Randi; Holst, Jens Juul; Steiner, Donald F.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 16, 06.08.2002, p. 10293-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2003
  17. Published

    Characterization of GLP-1 effects on beta cell function after meal ingestion in humans. / Ahren, B.; Holst, Jens Juul; Mari, A.

    In: Diabetes Care, No. 26, 2003, p. 2860-2864.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans. / Ahrén, Bo; Holst, Jens Juul; Mari, Andrea.

    In: Diabetes Care. Supplement, Vol. 26, No. 10, 10.2003, p. 2860-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Lower glucose-dependent insulinotropic polypeptide (GIP) response but similar glucagon-like peptide 1 (GLP-1), glycaemic, and insulinaemic response to ancient wheat compared to modern wheat depends on processing. / Bakhøj, S; Flint, A.; Holst, Jens Juul; Tetens, Inge.

    In: European Journal of Clinical Nutrition, Vol. 57, No. 10, 2003, p. 1254-1261.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid small bowel resection. / Dahly, E.M.; Gillingham, M.B.; Guo, Z.; Murali, S.G.; Nelson, D.W.; Holst, Jens Juul; Ney, D.M.

    In: Amer. J. Physiol., No. 284, 2003, p. G670-G682.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection. / Dahly, Elizabeth M; Gillingham, Melanie B; Guo, Ziwen; Murali, Sangita G; Nelson, David W; Holst, Jens Juul; Ney, Denise M.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 284, No. 4, 04.2003, p. G670-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Differential regional metabolism of glucagon in anesthetized pigs. / Deacon, Carolyn F; Kelstrup, Mette; Trebbien, Ramona; Klarskov, Letty; Olesen, Mette; Holst, Jens J.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 285, No. 3, 2003, p. E552-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Lower blood glucose, hyperglucagonemia and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. / Gelling, R.W.; Du, X.Q.; Dichmann, D.S.; Rømer, J.; Huan, H.; Cui, L.; Tang, B.L.; Holst, Jens Juul; Fledelius, C.; Johansen, P.B.; Jelicks, L.A.; Serup, P.; Nishimura, E.; Charron, M.J.

    In: Proc Natl Sci, No. 100, 2003, p. 1438-1443.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    GLP-2 mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TNP-fed piglets. / Guan, X.; Stoll, B.; Lu, X.; Tappenden, K.; Holst, Jens Juul; Hartmann, Bolette; Burrin, D.G.

    In: Today in Medicine. Gastroenterology, No. 125, 2003, p. 136-147.

    Research output: Contribution to journalJournal articleResearch

  25. Published

    GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1. / Guan, Xinfu; Stoll, Barbara; Lu, Xiaofeng; Tappenden, Kelly A; Holst, Jens Juul; Hartmann, Bolette; Burrin, Douglas G.

    In: Gastroenterology, Vol. 125, No. 1, 07.2003, p. 136-47.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Role of gastrointestinal hormones in postprandial reduction of bone resorption. / Henriksen, Dennis B; Alexandersen, Peter; Bjarnason, Nina H; Vilsbøll, Tina; Hartmann, Bolette; Henriksen, Eva E G; Byrjalsen, Inger; Krarup, Thure; Holst, Jens Juul; Christiansen, Claus.

    In: J Bone Miner Res, Vol. 18, No. 12, 01.12.2003, p. 2180-2190.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Implementation of GLP-1 based therapy of type 2 diabetes mellitus using DPP-IV inhibitors. / Holst, Jens Juul.

    In: Advances in Experimental Medicine and Biology, Vol. 524, 2003, p. 263-79.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Will GLP-1 treatment increase blood pressure? Summary and comment. / Holst, Jens Juul.

    In: Diabetes Monitor, No. 15, 2003, p. 15-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Small intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. / Jackson, R.S.; Creemers, J.W.M.; Saraf Faraoqi, I.; Raffin-Sanson, M.L.; Varro, A.; Dockray, G.J.; Holst, J.J.; Brubaker, P.L.; Corvol, P.; Polonsky, K.S.; Ostrega, D.; Becker, K.L.; Bertagna, X.; Hutton, J.C.; White, A.; Dattani, M.T.; Hussain, K.; Middleton, S.J.; Nicholl, T.M.; Lindley, K.J.; O Rahlly, S.

    In: J. Clin. Invest., No. 112, 2003, p. 1550-1560.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. / Jackson, Robert S; Creemers, John W M; Farooqi, I Sadaf; Raffin-Sanson, Marie-Laure; Varro, Andrea; Dockray, Graham J; Holst, Jens Juul; Brubaker, Patricia L; Corvol, Pierre; Polonsky, Kenneth S; Ostrega, Diane; Becker, Kenneth L; Bertagna, Xavier; Hutton, John C; White, Anne; Dattani, Mehul T; Hussain, Khalid; Middleton, Stephen J; Nicole, Thomasina M; Milla, Peter J; Lindley, Keith J; O'Rahilly, Stephen.

    In: The Journal of Clinical Investigation, Vol. 112, No. 10, 11.2003, p. 1550-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men. / Jensen, Christine B; Storgaard, Heidi; Holst, Jens Juul; Dela, Flemming; Madsbad, Sten; Vaag, Allan A.

    In: The Journal of clinical endocrinology and metabolism, Vol. 88, No. 6, 06.2003, p. 2775-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men. / Jensen, Christine B; Storgaard, Heidi; Holst, Jens Juul; Dela, Flemming; Madsbad, Sten; Vaag, Allan A.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 88, No. 6, 2003, p. 2775-2783.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Structural differences between rye and wheat bread but not total fiber content may explain the lower postprandial insulin response to rye bread. / Juntunen, K.S.; Laaksonen, D.E.; Aitio, K.; Niskanen, L.K.; Holst, J.J.; Savolainen, K.E.; Liukkonen, K.H.; Poutanen, K.S.; Mykkänen, H.M.

    In: Am. J. Clin. Nutr., No. 78, 2003, p. 957-964.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread. / Juntunen, Katri S; Laaksonen, David E; Autio, Karin; Niskanen, Leo K; Holst, Jens Juul; Savolainen, Kari E; Liukkonen, Kirsi-Helena; Poutanen, Kaisa S; Mykkänen, Hannu M.

    In: Uden navn, Vol. 78, No. 5, 11.2003, p. 957-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The influence of GLP-1 on glucose-induced insulin secretion: effect on ß-cells sensitivity in type 2 and non-diabetic subjects. / Kjems, L.L.; Holst, Jens Juul; Vølund, A.A.; Madsbad, S.

    In: Diabetes, No. 52, 2003, p. 380-386.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The influence of GLP-1 on glucose-stimulated insulin secretion : effects on beta-cell sensitivity in type 2 and nondiabetic subjects. / Kjems, Lise L; Holst, Jens Juul; Vølund, Aage; Madsbad, Sten.

    In: Diabetes, Vol. 52, No. 2, 02.2003, p. 380-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    No reactive hypoglycaemia after subcutaneous administrations of GLP-1 in lean type 2 diabetic patients and in patients with diabeties secondary to chronic pancreatitis. / Knop, F.; Vilsbøll, T.; Larsen, S.; Holst, Jens Juul; Krarup, T.

    In: Diabetes Care, No. 26, 2003, p. 2581-2587.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit. / Larsen, P J; Seier, V; Fink-Jensen, A; Holst, Jens Juul; Warberg, J; Vrang, N.

    In: Journal of Neuroendocrinology, Vol. 15, No. 3, 03.2003, p. 219-26.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Cocaine and amphetamine-regulated transcript (CART) is present in hypothalamic neuroendocrine neurons and is related to the hypothalamo-pituitary portal circuit. / Larsen, P.J.; Seier, V.; Fink-Jensen, A.; Holst, Jens Juul; Warberg, Jørgen; Vrang, N.

    In: Journal of Neuroendocrinology, No. 15, 2003, p. 219-226.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. / Meier, J J; Gallwitz, B; Siepmann, N; Holst, Jens Juul; Deacon, C F; Schmidt, W E; Nauck, M A.

    In: Diabetologia, Vol. 46, No. 6, 06.2003, p. 798-801.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. / Meier, J.J.; Gallwitz, N.; Siepmann, N.; Holst, Jens Juul; Deacon, C.F.; Schmidt, W.E.; Nauck, M.A.

    In: Diabetologia, No. 46, 2003, p. 798-801.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Normalisation of glucose concentrations and deceleration of gastric emptying of solid meals during intravenous glucagon-like peptide-1 (GLP-1) in patients with type 2 diabetes. / Meier, J.J.; Gallwitz, B.; Salmen, S.; Goetze, O.; Holst, Jens Juul; Schmidt, W.E.

    In: J. Clin. Endocrinol. Metab., No. 88, 2003, p. 2719-2725.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Gastric inhibitory polypeptide (GIP) does not inhibit gastric emptying in man. / Meier, J.M.; Goetze, O.; Anstipp, J.; Hagemann, D.; Holst, J.J.; Schmidt, W.E.; Gallwitz, B.; Nauck, M.A.

    In: Am. J. Physiol., No. 16, 2003, p. E621-E625.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. / Meier, Juris J; Gallwitz, Baptist; Salmen, Stefan; Goetze, Oliver; Holst, Jens Juul; Schmidt, Wolfgang E; Nauck, Michael A.

    In: The Journal of clinical endocrinology and metabolism, Vol. 88, No. 6, 06.2003, p. 2719-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects. / Meier, Juris J; Nauck, Michael A; Siepmann, Nina; Greulich, Michael; Holst, Jens J; Deacon, Carolyn F; Schmidt, Wolfgang E; Gallwitz, Baptist.

    In: Metabolism - Clinical and Experimental, Vol. 52, No. 12, 2003, p. 1579-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP). / Meier, Juris J; Gallwitz, Baptist; Siepmann, Nina; Holst, Jens J; Deacon, Carolyn F; Schmidt, Wolfgang E; Nauck, Michael A.

    In: Regulatory Peptides, Vol. 113, No. 1-3, 2003, p. 95-100.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Absence of a memory effect for the insulinotropic action of glucagon-like peptide 1 (GLP-1) in healthy volunteers. / Meier, S; Hücking, K; Ritzel, R; Holst, Jens Juul; Schmiegel, W H; Nauck, M A.

    In: Hormone and Metabolic Research. Supplement, Vol. 35, No. 9, 09.2003, p. 551-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Absence of a memory effect for the insulinotropic action of glucagon-like peptide 1(GLP-1) in healthy volunteers. / Meier, S.; Hücking, K.; Ritzelt, R.; Holst, Jens Juul; Schmiegel, W.H.; Nauck, M.A.

    In: Horm Metab Res, No. 35, 2003, p. 551-556.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Comparisons of leptin, incretins and body composition in obese and lean patients with hypopituitarism and healthy individuals. / Mersebach, H.; Svendsen, Ole Lander; Holst, Jens Juul; Astrup, Arne; Feldt-Rasmussen, Ulla.

    In: Clinical Endocrinology, Vol. 58, No. 1, 2003, p. 65-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. / Mortensen, Kristine; Christensen, Louise Lundby; Holst, Jens Juul; Ørskov, Cathrine.

    In: Regulatory Peptides, Vol. 114, No. 2-3, 2003, p. 189-96.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Prediction of glycemic index in mixed meals. / Møller, B. K.; Flint, A.; Pedersen, D.; Raben, A. B.; Tetens, I.; Holst, Jens Juul; Astrup, A.

    2003. Paper presented at European Congress on Obesity, International Journal of Obesity, Helsinki, .

    Research output: Contribution to conferencePaperResearch

  52. Published

    Somatostatin receptors. / Møller, Lars Neisig; Stidsen, Carsten Enggaard; Hartmann, Bolette; Holst, Jens Juul.

    In: BBA General Subjects, Vol. 1616, No. 1, 2003, p. 1-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

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