Hanne Mørck Nielsen

Hanne Mørck Nielsen

Professor


  1. 2019
  2. Published

    Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers. / Stie, Mai Bay; Jones, Megan; Osholm Sørensen, Henning; Jacobsen, Jette; Chronakis, Ioannis S. ; Nielsen, Hanne Mørck.

    In: Carbohydrate Polymers, 01.07.2019, p. 253.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model. / Jansen, Manon A A; Klausen, Lasse H; Thanki, Kaushik; Lyngsø, Jeppe; Skov Pedersen, Jan; Franzyk, Henrik; Nielsen, Hanne M; van Eden, Willem; Dong, Mingdong; Broere, Femke; Foged, Camilla; Zeng, Xianghui.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 11.06.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. E-pub ahead of print

    Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring. / Wan, Feng; Nylander, Tommy; Foged, Camilla; Yang, Mingshi; Baldursdottir, Stefania G; Nielsen, Hanne M.

    In: Journal of Colloid and Interface Science, Vol. 545, 01.03.2019, p. 162-171.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR. / Christensen, Malene Vinther; Kongstad, Kenneth Thermann; Sondergaard, Teis Esben; Stærk, Dan; Nielsen, Hanne Mørck; Franzyk, Henrik; Wimmer, Reinhard.

    In: Journal of Biomolecular N M R, Vol. 73, 2019, p. 167-182.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients. / Molchanova, Natalia; Wang, Hengzhuang; Hansen, Paul R; Høiby, Niels; Nielsen, Hanne M; Franzyk, Henrik.

    In: Frontiers in Microbiology, Vol. 10, 275, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators. / Baker, Kristin R; Jana, Bimal; Hansen, Anna Mette; Vissing, Karina Juul; Nielsen, Hanne Mørck; Franzyk, Henrik; Guardabassi, Luca.

    In: International Journal of Antimicrobial Agents, Vol. 53, 2019, p. 868-872.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2018
  9. Published

    Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages. / Priemel, Petra A.; Wang, Yingya; Bohr, Adam; Water, Jorrit J.; Yang, Mingshi; Nielsen, Hanne Morck.

    In: Journal of Pharmacy and Pharmacology, Vol. 70, No. 8, 08.2018, p. 1009-1021.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic. / Kłodzińska, Sylvia Natalie; Molchanova, Natalia; Franzyk, Henrik; Hansen, Paul Robert; Damborg, Peter; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 128, 07.2018, p. 1-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Immunogenicity Testing of Lipidoids In Vitro and In Silico : Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design. / de Groot, Anne Marit; Thanki, Kaushik; Gangloff, Monique; Falkenberg, Emily; Zeng, Xianghui; van Bijnen, Djai C J; van Eden, Willem; Franzyk, Henrik; Nielsen, Hanne M; Broere, Femke; Gay, Nick J; Foged, Camilla; Sijts, Alice J A M.

    In: Molecular Therapy - Nucleic Acids, Vol. 11, 01.06.2018, p. 159-169.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium. / Birch, Ditlev; Diedrichsen, Ragna G; Christophersen, Philip C; Mu, Huiling; Nielsen, Hanne M.

    In: European Journal of Pharmaceutical Sciences, Vol. 118, 06.2018, p. 144-153.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Biochemical Journal, Vol. 475, No. 10, 24.05.2018, p. 1773-1788.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma. / Greco, Ines; Hummel, Bernard D.; Vasir, Jaspreet; Watts, Jeffrey L.; Koch, Jason ; Hansen, Johannes E.; Nielsen, Hanne Mørck; Damborg, Peter Panduro; Hansen, Paul Robert.

    In: Molecules, Vol. 23, No. 3, 630, 10.03.2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms. / Wan, Feng; Nylander, Tommy; Klodzinska, Sylvia Natalie; Foged, Camilla; Yang, Mingshi; Baldursdottir, Stefania G; Mørck Nielsen, Hanne.

    In: A C S Applied Materials and Interfaces, Vol. 10, No. 13, 23.02.2018, p. 10678–10687.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing. / Liu, Xiaoli; Nielsen, Line Hagner; Klodzinska, Sylvia Natalie; Nielsen, Hanne Mørck; Qu, Haiyan; Christensen, Lars Porskjær; Rantanen, Jukka; Yang, Mingshi.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 123, 02.2018, p. 42-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Combining diagnostic methods for antimicrobial susceptibility testing – A comparative approach. / Klodzinska, Sylvia Natalie; Priemel, Petra Alexandra; Rades, Thomas; Nielsen, Hanne Mørck.

    In: Journal of Microbiological Methods, Vol. 144, 01.2018, p. 177-185.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles. / García-Díaz, María; Birch, Ditlev; Wan, Feng; Nielsen, Hanne Mørck.

    In: Advanced Drug Delivery Reviews, Vol. 124, 01.2018, p. 107-124.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH. / Kristensen, Mie; Nielsen, Line Hagner; Zor, Kinga; Boisen, Anja; Christensen, Malene Vinther; Berthelsen, Jens; Nielsen, Hanne Mørck.

    In: Bioconjugate Chemistry, Vol. 29, No. 2, 2018, p. 371-381.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Comparative study of the drug delivery mechanism of L-penetratin and D-penetratin. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2018. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  21. Published

    Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction. / Hedegaard, Sofie Fogh; Derbas, Mohammed Sobhi; Lind, Tania Kjellerup; Kasimova, Marina Robertnova; Christensen, Malene Vinther; Michaelsen, Maria Høtoft; Campbell, Richard A; Jorgensen, Lene; Franzyk, Henrik; Cárdenas, Marité; Nielsen, Hanne Mørck.

    In: Scientific Reports, Vol. 8, No. 1, 6327, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies. / Thanki, Kaushik; Thakur, Aneesh; de Groot, A. M.; Geyer, A.; Fraire, Juan; Falkenberg, Emily; Van Eygen, Hannelore; Putteman, Emma; Van Bijnen, Djai C. J.; Zeng, Xianghui; Sami, H.; Gehrig, S. ; Justesen, Sarah; Franzyk, Henrik; Broere, Femke; van Eden, Willem; Sijts, Alice J A M; Ogris, M.; Nielsen, Hanne Mørck; Braeckmans, Kevin; Foged, Camilla.

    2018. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  23. 2017
  24. Published

    Animal models for evaluation of oral delivery of biopharmaceuticals. / Harloff-Helleberg, Stine; Nielsen, Line Hagner; Nielsen, Hanne Mørck.

    In: Journal of Controlled Release, Vol. 268, 12.2017, p. 57-71.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    The impact of particle preparation methods and polymorphic stability of lipid excipients on protein distribution in microparticles. / Liu, Jingying; Christophersen, Philip C; Yang, Mingshi; Nielsen, Hanne M; Mu, Huiling.

    In: Drug Development and Industrial Pharmacy, Vol. 43, No. 12, 12.2017, p. 2032-2042.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach. / Thanki, Kaushik; Zeng, Xianghui; Justesen, Sarah; Tejlmann, Sarah; Falkenberg, Emily; Van Driessche, Elize; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 120, 11.2017, p. 22-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA. / Foged, Camilla (Inventor); Franzyk, Henrik (Inventor); Zeng, Xianghui (Inventor); Nielsen, Hanne Mørck (Inventor); Thanki, Kaushik (Inventor).

    IPC No.: A61K31/713, A61K47/18, A61K47/34, A61K9/51, A61P25/00, A61P29/00, A61P35/00. Patent No.: WO2017158093-A1. Mar 16, 2017.

    Research output: PatentResearch

  28. Published

    Innovative Methods and Applications in Mucoadhesion Research. / Mackie, Alan R; Goycoolea, Francisco M; Menchicchi, Bianca; Caramella, Carla Marcella; Saporito, Francesca; Lee, Seunghwan; Stephansen, Karen; Chronakis, Ioannis S; Hiorth, Marianne; Adamczak, Malgorzata; Waldner, Max; Nielsen, Hanne Mørck; Marcelloni, Luciano.

    In: Macromolecular Bioscience, Vol. 17, No. 8, 1600534, 08.2017.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Assessment of mucoadhesion using small deformation rheology revisited. / Harloff-Helleberg, Stine; Vissing, Karina Juul; Nielsen, Hanne Mørck.

    In: Nordic Rheology Society Annual Transactions, Vol. 25, 04.2017, p. 63.

    Research output: Contribution to journalConference articleResearchpeer-review

  30. Published

    An approach to identify clinically relevan, non-toxic peptide-antimicrobial combinations that eliminate intrinsic resistance in Gram-negative pathogens. / Baker, Kristin Renee; Jana, Bimal; Nielsen, Hanne Mørck; Franzyk, Henrik; Guardabassi, Luca.

    2017. Abstract from ASM Microbe 2017, New Orleans, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  31. An approach to identify clinically relevan, non-toxic peptide-antimicrobial combinations that eliminate intrinsic resistance in Gram-negative pathogens. / Baker, Kristin Renee; Jana, Bimal; Nielsen, Hanne Mørck; Franzyk, Henrik; Guardabassi, Luca.

    2017. Abstract from ASM Microbe 2017, New Orleans, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  32. Published

    Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs. / Thanki, Kaushik; Zeng, Xianghui; Justesen, Sarah; Tejlmann, Sarah; Falkenberg, Emily; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    2017. Poster session presented at 6th FIP Pharmaceutical Sciences World Congress (PSWC), Stockholm, Sweden.

    Research output: Contribution to conferencePosterResearch

  33. Published

    Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: B B A - Biomembranes, Vol. 1859, No. 12, 2017, p. 2483-2494.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published
  35. Published

    Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA. / Zeng, Xianghui; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    2017. Abstract from 2nd Gazi Pharma Symposium Series, Ankara, Turkey.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  36. Published

    Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy. / Falkenberg, Emily; de Groot, Anne Marit; Sijts, Alice J A M; Thanki, Kaushik; Zeng, Xianghui; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    2017. Poster session presented at 10th European Workshop on Particulate Systems (EWPS), Copenhagen, Denmark.

    Research output: Contribution to conferencePosterResearch

  37. 2016
  38. Published

    Inhalable Antimicrobials for Treatment of Bacterial Biofilm-Associated Sinusitis in Cystic Fibrosis Patients : Challenges and Drug Delivery Approaches. / Klodzinska, Sylvia Natalie; Priemel, Petra Alexandra; Rades, Thomas; Mørck Nielsen, Hanne.

    In: International Journal of Molecular Sciences , Vol. 17, No. 10, 1688, 09.10.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers. / Li, Ping; Nielsen, Hanne Mørck; Müllertz, Anette.

    In: Journal of Pharmaceutical Sciences, Vol. 105, No. 9, 09.2016, p. 2743-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System. / Jing, Xiaona; Foged, Camilla; Martin-Bertelsen, Birte; Yaghmur, Anan; Knapp, Kolja Michael; Malmsten, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Molecular Pharmaceutics, Vol. 13, No. 6, 06.06.2016, p. 1739-1749.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System. / Jing, Xiaona; Foged, Camilla; Martin-Bertelsen, Birte; Yaghmur, Anan; Knapp, Kolja Michael; Malmsten, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Molecular Pharmaceutics, Vol. 13, No. 6, 06.06.2016, p. 1739-1749.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Issues in development of biodrug delivery systems. / Jørgensen, Lene; Frokjaer, Sven; Nielsen, Hanne Mørck.

    Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. CRC Press, 2016. p. 13-25.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  43. Published

    Interactions between Surfactants in Solution and Electrospun Protein Fibers : Effects on Release Behavior and Fiber Properties. / Stephansen, Karen; García-Díaz, María; Jessen, Flemming; Chronakis, Ioannis S; Nielsen, Hanne M.

    In: Molecular Pharmaceutics, Vol. 13, No. 3, 07.03.2016, p. 748-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Cell-Penetrating Peptides as Carriers for Oral Delivery of Biopharmaceuticals. / Kristensen, Mie; Nielsen, Hanne Mørck.

    In: Basic & Clinical Pharmacology & Toxicology Online, Vol. 118, No. 2, 02.2016, p. 99-106.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos. / Kristensen, Mie; Birch, Ditlev; Mørck Nielsen, Hanne.

    In: International Journal of Molecular Sciences , Vol. 17, No. 2, 185, 30.01.2016, p. 1-17.

    Research output: Contribution to journalReviewResearchpeer-review

  46. Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals. / Kristensen, Mie; Nielsen, Hanne Mørck.

    In: Tissue Barriers, Vol. 4, No. 2, e1178369, 2016.

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals. / Kristensen, Mie; Nielsen, Hanne Mørck.

    In: Tissue Barriers, Vol. 4, No. 2, e1178369, 2016.

    Research output: Contribution to journalReviewResearchpeer-review

  48. Published

    Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking. / Thanki, Kaushik; Geyer, A.; Zeng, Xianghui; Sami, H.; Gehrig, S. ; Justesen, Sarah; Franzyk, Henrik; Ogris, M.; Nielsen, Hanne Mørck; Foged, Camilla.

    2016. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences (AAPS) 2016, Denver, United States.

    Research output: Contribution to conferencePosterResearch

  49. Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking. / Thanki, Kaushik; Geyer, A.; Zeng, Xianghui; Sami, H.; Gehrig, S.; Justesen, Sarah; Franzyk, Henrik; Ogris, M.; Nielsen, Hanne Mørck; Foged, Camilla.

    2016. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences (AAPS) 2016, Denver, United States.

    Research output: Contribution to conferencePosterResearch

  50. Published

    Large-scale biophysical evaluation of protein PEGylation effects : in vitro properties of 61 protein entities. / Vernet, Erik; Popa, Gina; Pozdnyakova, Irina; Rasmussen, Jakob Ewald; Grohganz, Holger; Giehm, Lise; Jensen, Malene Hillerup; Wang, Huabing; Plesner, Bitten; Nielsen, Hanne Mørck; Jensen, Knud Jørgen; Berthelsen, Jens; Sundström, Michael; van de Weert, Marco.

    In: Molecular Pharmaceutics, Vol. 13, No. 5, 2016, p. 1587-1598.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Quantification of pharmaceutical peptides in human plasma by LC-ICP-MS sulfur detection. / Møller, Laura Hyrup; Macherius, André; Hansen, Thomas Hesselhøj; Nielsen, Hanne Mørck; Cornett, Claus; Østergaard, Jesper; Stürup, Stefan; Gammelgaard, Bente.

    In: Journal of Analytical Atomic Spectrometry, Vol. 31, 2016, p. 1877-1884.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices. / Steffensen, Søren Langer; Merete H., Vestergaard,; Møller, Eva Horn; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials, Vol. 104, No. 2, 2016, p. 402-410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices. / Steffensen, Søren Langer; Merete H., Vestergaard,; Møller, Eva Horn; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials, Vol. 104, No. 2, 2016, p. 402-410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2015
  55. Published

    Antimicrobial activity of GN peptides and their mode of action. / Godballe, Troels; Mojsoska, Biljana; Nielsen, Hanne M; Jenssen, Håvard.

    In: Biopolymers, Vol. 106, No. 2, 13.12.2015, p. 172–183.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Bioactive protein-based nanofibers interact with intestinal biological components resulting in transepithelial permeation of a therapeutic protein. / Stephansen, Karen; García-Díaz, María; Jessen, Flemming; Chronakis, Ioannis S; Nielsen, Hanne Mørck.

    In: International Journal of Pharmaceutics, Vol. 495, No. 1, 10.11.2015, p. 58-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation. / Bøgh, Marie; García-Díaz, María; Müllertz, Anette; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, No. Part A, 09.2015, p. 136–143.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin. / Water, Jorrit J; Kim, YongTae; Maltesen, Morten J; Franzyk, Henrik; Foged, Camilla; Nielsen, Hanne M.

    In: Pharmaceutical Research, Vol. 32, No. 8, 08.2015, p. 2727-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles. / Colombo, Stefano; Cun, Dongmei; Remaut, Katrien; Bunker, Matt; Zhang, Jianxin; Martin-Bertelsen, Birte; Yaghmur, Anan; Braeckmans, Kevin; Nielsen, Hanne M; Foged, Camilla.

    In: Journal of Controlled Release, Vol. 201, 10.03.2015, p. 22-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Mucus as a Barrier to Drug Delivery : Understanding and Mimicking the Barrier Properties. / Bøgh, Marie; Nielsen, Hanne Mørck.

    In: Basic & Clinical Pharmacology & Toxicology, Vol. 116, No. 3, 03.2015, p. 179-186.

    Research output: Contribution to journalReviewResearchpeer-review

  61. Published

    Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells. / Water, Jorrit Jeroen; Smart, Simon; Franzyk, Henrik; Foged, Camilla; Nielsen, Hanne Mørck.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 92, 18.02.2015, p. 65-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Selenium as an alternative peptide label - comparison to fluorophore-labelled penetratin. / Hyrup Møller, Laura; Bahnsen, Jesper Søborg; Nielsen, Hanne Mørck; Østergaard, Jesper; Stürup, Stefan; Gammelgaard, Bente.

    In: European Journal of Pharmaceutical Sciences, Vol. 67, 25.01.2015, p. 76-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    End Group Modification : Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria. / Jahnsen, Rasmus O; Sandberg-Schaal, Anne; Frimodt-Møller, Niels; Nielsen, Hanne Mørck; Franzyk, Henrik.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 95, No. Part A, 23.01.2015, p. 40–46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Three-Dimensional Printing of Drug-Eluting Implants : Preparation of an Antimicrobial Polylactide Feedstock Material. / Water, Jorrit Jeroen; Bohr, Adam; Bøtker, Johan Peter; Aho, Johanna; Sandler, Niklas; Nielsen, Hanne Mørck; Rantanen, Jukka.

    In: Journal of Pharmaceutical Sciences, 15.01.2015, p. 1099–1107.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy. / Christophersen, Philip C.; Birch, Ditlev; Saarinen, Jukka; Isomäki, Antti; Nielsen, Hanne M.; Yang, Mingshi; Strachan, Clare J.; Mu, Huiling.

    In: Journal of Controlled Release, Vol. 197, 10.01.2015, p. 111-120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published
  67. Carrier peptide-mediated transepithelial permeation of biopharmaceuticals : Effect of co-administration versus direct conjugation. / Kristensen, Mie; Nielsen, Hanne Mørck.

    2015.

    Research output: Contribution to conferencePosterResearchpeer-review

  68. Published

    Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections. / Bahnsen, Jesper S; Franzyk, Henrik; Sayers, Edward J; Jones, Arwyn T; Nielsen, Hanne M.

    In: Pharmaceutical Research, Vol. 32, No. 5, 2015, p. 1546-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro. / Rønholt, Stine; Kristensen, Mie; Nielsen, Hanne Mørck.

    Cell-penetrating peptides : Methods and Protocols. ed. / Ülo Langel. Vol. 1324 2015. p. 261-277.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  70. Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro. / Rønholt, Stine; Kristensen, Mie; Nielsen, Hanne Mørck.

    Cell-penetrating peptides: Methods and Protocols. ed. / Ülo Langel. Vol. 1324 2015. p. 261-277.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  71. Published

    Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs. / Christophersen, Philip Carsten; Fano, Mathias; Saaby, Lasse; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling.

    In: Current Pharmaceutical Design, Vol. 21, No. 19, 2015, p. 2611-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Conjugation of a cell-penetrating peptide to parathyroid hormone affects its structure, potency, and transepithelial permeation. / Kristensen, Mie; de Groot, Anne Marit; Berthelsen, Jens; Franzyk, Henrik; Sijts, Alice; Nielsen, Hanne Mørck.

    In: Bioconjugate Chemistry, Vol. 26, 2015, p. 477-488.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Improved insulin loading in poly (lactic-co-glycolic) acid (PLGA) nanoparticles upon self-assembly with lipids. / Garcia Diaz, Maria; Foged, Camilla; Nielsen, Hanne Mørck.

    In: International Journal of Pharmaceutics, Vol. 482, 2015, p. 84-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Improved insulin loading in poly (lactic-co-glycolic) acid (PLGA) nanoparticles upon self-assembly with lipids. / Garcia Diaz, Maria; Foged, Camilla; Nielsen, Hanne Mørck.

    In: International Journal of Pharmaceutics, Vol. 482, 2015, p. 84-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Intact penetratin metabolite permeates across Caco-2 monolayers. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2015. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences, Orlando, Florida, United States.

    Research output: Contribution to conferencePosterResearch

  76. Published

    Intact penetratin metabolite permeates across Caco-2 monolayers. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2015. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences, Orlando, Florida, United States.

    Research output: Contribution to conferencePosterResearch

  77. Published

    Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites. / Schmidt, Marianne Molander; Stærk, Dan; Nielsen, Hanne Mørck; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; Van Staden, Johannes; Jäger, Anna.

    In: Journal of Ethnopharmacology, Vol. 165, 2015, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites. / Schmidt, Marianne Molander; Stærk, Dan; Nielsen, Hanne Mørck; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; Van Staden, Johannes; Jäger, Anna.

    In: Journal of Ethnopharmacology, Vol. 165, 2015, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation. / Kristensen, Mie; Franzyk, Henrik; Klausen, M. T. ; Iversen, A; Bahnsen, Jesper Søborg; Skyggebjerg, R. B.; Foderà, Vito; Nielsen, Hanne Mørck.

    In: A A P S Journal, Vol. 17, No. 5, 2015, p. 1200-1209.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation. / Kristensen, Mie; Franzyk, Henrik; Klausen, M. T.; Iversen, A; Bahnsen, Jesper Søborg; Skyggebjerg, R. B.; Foderà, Vito; Nielsen, Hanne Mørck.

    In: A A P S Journal, Vol. 17, No. 5, 2015, p. 1200-1209.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Penetratin-mediated transepithelial insulin pemeation: Importance of complexation? / Kristensen, Mie; Foderà, Vito; Nielsen, Hanne Mørck.

    2015.

    Research output: Contribution to conferencePosterResearchpeer-review

  82. Penetratin-mediated transepithelial insulin pemeation: Importance of complexation? / Kristensen, Mie; Foderà, Vito; Nielsen, Hanne Mørck.

    2015.

    Research output: Contribution to conferencePosterResearchpeer-review

  83. Reversible tight junction modulation using an enterotoxin-derived peptide as enhancer for delivery of biopharmaceuticals across biobarriers. / Kristensen, Mie; Nielsen, Hanne Mørck.

    2015. Poster session presented at Crossing Biological Barriers, Dresden, Germany.

    Research output: Contribution to conferencePosterResearchpeer-review

  84. Published

    Reversible tight junction modulation using an enterotoxin-derived peptide as enhancer for delivery of biopharmaceuticals across biobarriers. / Kristensen, Mie; Nielsen, Hanne Mørck.

    2015. Poster session presented at Crossing Biological Barriers, Dresden, Germany.

    Research output: Contribution to conferencePosterResearchpeer-review

  85. Published

    Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro. / Zeng, Xianghui; de Groot, A. M.; Sijts, Alice; Blenke, E. O.; Colombo, Stefano; van Eden, W; Franzyk, Henrik; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Nanoscale, Vol. 7, No. 46, 2015, p. 19687-19698.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro. / Zeng, Xianghui; de Groot, A. M.; Sijts, Alice; Blenke, E. O.; Colombo, Stefano; van Eden, W; Franzyk, Henrik; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Nanoscale, Vol. 7, No. 46, 2015, p. 19687-19698.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices. / Steffensen, Søren Langer; Merete H., Vestergaard,; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, 2015, p. 305-311.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices. / Steffensen, Søren Langer; Merete H., Vestergaard,; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, 2015, p. 305-311.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. 2014
  90. Published

    Self-nanoemulsifying drug delivery systems for oral insulin delivery : In vitro and in vivo evaluations of enteric coating and drug loading. / Li, Ping; Tan, Angel; Prestidge, Clive A; Nielsen, Hanne Mørck; Müllertz, Anette.

    In: International Journal of Pharmaceutics, Vol. 477, No. 1-2, 30.12.2014, p. 390-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models. / Ingvarsson, Pall Thor; Rasmussen, Ida Svahn; Viaene, Michelle; Irlik, Przemyslaw Jedrzej; Nielsen, Hanne Mørck; Foged, Camilla.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 87, No. 3, 08.2014, p. 480-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin. / Christophersen, Philip C; Vaghela, Dimple; Müllertz, Anette; Yang, Mingshi; Nielsen, Hanne M; Mu, Huiling.

    In: A A P S Journal, Vol. 16, No. 4, 07.2014, p. 875-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. AMP mimics with bactericidal activity against Staphylococci and Pseudomonas as novel drugs for topical use in veterinary medicine. / Greco, Ines; Damborg, Peter Panduro; Guardabassi, Luca; Nielsen, Hanne Mørck; Hansen, Paul Robert.

    2014. Poster session presented at AMP 2014 - 4th International Symposium on Antimicrobial Peptides, LLorient, France.

    Research output: Contribution to conferencePosterResearchpeer-review

  94. Published

    AMP mimics with bactericidal activity against Staphylococci and Pseudomonas as novel drugs for topical use in veterinary medicine. / Greco, Ines; Damborg, Peter Panduro; Guardabassi, Luca; Nielsen, Hanne Mørck; Hansen, Paul Robert.

    2014. Poster session presented at AMP 2014 - 4th International Symposium on Antimicrobial Peptides, LLorient, France.

    Research output: Contribution to conferencePosterResearchpeer-review

  95. Published

    Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli. / Jahnsen, Rasmus D; Sandberg-Schaal, Anne; Vissing, Karina Juul; Nielsen, Hanne Mørck; Frimodt-Møller, Niels; Franzyk, Henrik.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 7, 20.03.2014, p. 2864-2873.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation. / Christophersen, Philip Carsten; Zhang, Long; Müllertz, Anette; Nielsen, Hanne Mørck; Yang, Mingshi; Mu, Huiling.

    In: Pharmaceutical Research, Vol. 31, No. 9, 13.03.2014, p. 2420-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption. / Bøgh, Marie; Baldursdóttir, Stefania G; Müllertz, Anette; Nielsen, Hanne M.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 87, 08.01.2014, p. 227-235.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Characterization of PTH-CPP fusion peptides for oral delivery. / Kristensen, Mie; Berthelsen, Jens; Nielsen, Hanne Mørck.

    2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  99. Published

    Characterization of PTH-CPP fusion peptides for oral delivery. / Kristensen, Mie; Berthelsen, Jens; Nielsen, Hanne Mørck.

    2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  100. Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics. / Water, Jorrit Jeroen; Maltesen, Morten Jonas; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  101. Published

    Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics. / Water, Jorrit Jeroen; Maltesen, Morten Jonas; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  102. Parathyroid hormone coupled to cell-penetrating peptides for oral delivery. / Kristensen, Mie; Nielsen, Hanne Mørck.

    2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  103. Published

    Parathyroid hormone coupled to cell-penetrating peptides for oral delivery. / Kristensen, Mie; Nielsen, Hanne Mørck.

    2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  104. Silicone embedded nanogels for prolonged resistance against biofilm formation. / Steffensen, Søren Langer; Vestergaard, M. H.; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  105. Published

    Silicone embedded nanogels for prolonged resistance against biofilm formation. / Steffensen, Søren Langer; Vestergaard, M. H.; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  106. Published

    Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles. / Christophersen, P.; Vaghela, D.; Müllertz, Anette; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling.

    2014. Abstract from 41st Controlled Release Society (CRS) Annual Meeting, Chicago, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

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