Hanne Mørck Nielsen

Hanne Mørck Nielsen

Professor


  1. Immunity by formulation design : induction of high CD8+ T-cell responses by poly (I:C) incorporated into the CAF01 adjuvant via a double emulsion method. / Nordly, Pernille Juul; Rose, Fabrice; Christensen, Dennis; Nielsen, Hanne Mørck; Andersen, Peter; Agger, Else Marie; Foged, Camilla.

    In: Journal of Controlled Release, Vol. 150, No. 3, 2011, p. 307-317.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Immunity by formulation design : induction of high CD8+ T-cell responses by poly (I:C) incorporated into the CAF01 adjuvant via a double emulsion method. / Nordly, Pernille Juul; Rose, Fabrice; Christensen, Dennis; Nielsen, Hanne Mørck; Andersen, Peter; Agger, Else Marie; Foged, Camilla.

    In: Journal of Controlled Release, Vol. 150, No. 3, 2011, p. 307-317.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Immunogenicity Testing of Lipidoids In Vitro and In Silico : Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design. / de Groot, Anne Marit; Thanki, Kaushik; Gangloff, Monique; Falkenberg, Emily; Zeng, Xianghui; van Bijnen, Djai C J; van Eden, Willem; Franzyk, Henrik; Nielsen, Hanne M; Broere, Femke; Gay, Nick J; Foged, Camilla; Sijts, Alice J A M.

    In: Molecular Therapy - Nucleic Acids, Vol. 11, 01.06.2018, p. 159-169.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats. / Vargas Christensen, Isabell; Loftager, Mette; Rode, Frederik; Mørck Nielsen, Hanne; Kreilgaard, Mads; Larsen, Malte Selch.

    In: Journal of Thrombosis and Haemostasis, Vol. 17, No. 6, 2019, p. 964-974.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers. / Li, Ping; Nielsen, Hanne Mørck; Müllertz, Anette.

    In: Journal of Pharmaceutical Sciences, Vol. 105, No. 9, 09.2016, p. 2743-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Improved insulin loading in poly (lactic-co-glycolic) acid (PLGA) nanoparticles upon self-assembly with lipids. / Garcia Diaz, Maria; Foged, Camilla; Nielsen, Hanne Mørck.

    In: International Journal of Pharmaceutics, Vol. 482, 2015, p. 84-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics. / Water, Jorrit Jeroen; Maltesen, Morten Jonas; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  8. Published

    Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics. / Water, Jorrit Jeroen; Maltesen, Morten Jonas; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  9. Published

    In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma. / Greco, Ines; Hummel, Bernard D.; Vasir, Jaspreet; Watts, Jeffrey L.; Koch, Jason ; Hansen, Johannes E.; Nielsen, Hanne Mørck; Damborg, Peter Panduro; Hansen, Paul Robert.

    In: Molecules, Vol. 23, No. 3, 630, 10.03.2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    In vitro placental model optimization for nanoparticle transport studies. / Cartwright, Laura; Poulsen, Marie Sønnegaard; Nielsen, Hanne Mørck; Pojana, Giulio; Knudsen, Lisbeth E.; Saunders, Margaret; Rytting, Erik.

    In: International Journal of Nanomedicine (Print), Vol. 7, 2012, p. 497-510.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    In vitro placental model optimization for nanoparticle transport studies. / Cartwright, Laura; Poulsen, Marie Sønnegaard; Nielsen, Hanne Mørck; Pojana, Giulio; Knudsen, Lisbeth E.; Saunders, Margaret; Rytting, Erik.

    In: International Journal of Nanomedicine (Online), Vol. 7, 2012, p. 497-510.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver. / Johansen, Torben Seested; Appa, R. S.; Christensen, E. I.; Ioannou, Y. A.; Krogh, T. N.; Karpf, D. M.; Nielsen, Hanne Mørck.

    In: Thrombosis Research, Vol. 127, No. 4, 2011, p. 356-362.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver. / Johansen, Torben Seested; Appa, R. S.; Christensen, E. I.; Ioannou, Y. A.; Krogh, T. N.; Karpf, D. M.; Nielsen, Hanne Mørck.

    In: Thrombosis Research, Vol. 127, No. 4, 2011, p. 356-362.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo. / Nordly, Pernille Juul; Korsholm, Karen Smith; Pedersen, Esra Alici; Khilji, Tayba Sajid; Franzyk, Henrik; Jørgensen, Lene; Nielsen, Hanne Mørck; Agger, Else Marie; Foged, Camilla.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 77, No. 1, 2011, p. 89-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo. / Nordly, Pernille Juul; Korsholm, Karen Smith; Pedersen, Esra Alici; Khilji, Tayba Sajid; Franzyk, Henrik; Jørgensen, Lene; Nielsen, Hanne Mørck; Agger, Else Marie; Foged, Camilla.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 77, No. 1, 2011, p. 89-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/DTDB liposomes  : physico-chemical characterization and induction of CD8+ T-Cell responses in vivo. / Nordly, Pernille Juul; Agger, Else Marie; Andersen, Peter; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Pharmaceutical Research, Vol. 28, No. 3, 2011, p. 553-562.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/DTDB liposomes  : physico-chemical characterization and induction of CD8+ T-Cell responses in vivo. / Nordly, Pernille Juul; Agger, Else Marie; Andersen, Peter; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Pharmaceutical Research, Vol. 28, No. 3, 2011, p. 553-562.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Influence of skin barrier on in-vitro penetration properties of solid lipid nanoparticles. / Jensen, Linda Boye; Nielsen, Hanne Mørck; Petersson, K.

    In: Journal of Pharmacy and Pharmacology, 2010, p. 793-794.

    Research output: Contribution to journalConference abstract in journalResearch

  19. Published

    Influence of skin barrier on in-vitro penetration properties of solid lipid nanoparticles. / Jensen, Linda Boye; Nielsen, Hanne Mørck; Petersson, K.

    In: Journal of Pharmacy and Pharmacology, 2010, p. 793-794.

    Research output: Contribution to journalConference abstract in journalResearch

  20. Published

    Inhalable Antimicrobials for Treatment of Bacterial Biofilm-Associated Sinusitis in Cystic Fibrosis Patients : Challenges and Drug Delivery Approaches. / Klodzinska, Sylvia Natalie; Priemel, Petra Alexandra; Rades, Thomas; Mørck Nielsen, Hanne.

    In: International Journal of Molecular Sciences , Vol. 17, No. 10, 1688, 09.10.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Innovative Methods and Applications in Mucoadhesion Research. / Mackie, Alan R; Goycoolea, Francisco M; Menchicchi, Bianca; Caramella, Carla Marcella; Saporito, Francesca; Lee, Seunghwan; Stephansen, Karen; Chronakis, Ioannis S; Hiorth, Marianne; Adamczak, Malgorzata; Waldner, Max; Nielsen, Hanne Mørck; Marcelloni, Luciano.

    In: Macromolecular Bioscience, Vol. 17, No. 8, 1600534, 08.2017.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Innovativt nanopartikeldesign bag skræddersyede vacciner. / Nordly, Pernille Juul; Agger, Else Marie; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Lægemiddelforskning, 2009, p. 19-21.

    Research output: Contribution to journalJournal articleResearch

  23. Published

    Innovativt nanopartikeldesign bag skræddersyede vacciner. / Nordly, Pernille Juul; Agger, Else Marie; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Lægemiddelforskning, 2009, p. 19-21.

    Research output: Contribution to journalJournal articleResearch

  24. Published

    Intact penetratin metabolite permeates across Caco-2 monolayers. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2015. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences, Orlando, Florida, United States.

    Research output: Contribution to conferencePosterResearch

  25. Intact penetratin metabolite permeates across Caco-2 monolayers. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2015. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences, Orlando, Florida, United States.

    Research output: Contribution to conferencePosterResearch

  26. Published

    Interaction of Laponite with Membrane Components-Consequences for Bacterial Aggregation and Infection Confinement. / Malekkhaiat Häffner, Sara; Nyström, Lina; Browning, Kathryn L; Mörck Nielsen, Hanne; Strömstedt, Adam A; van der Plas, Mariena J A; Schmidtchen, Artur; Malmsten, Martin.

    In: A C S Applied Materials and Interfaces, Vol. 11, No. 17, 01.05.2019, p. 15389-15400.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Interactions between Surfactants in Solution and Electrospun Protein Fibers : Effects on Release Behavior and Fiber Properties. / Stephansen, Karen; García-Díaz, María; Jessen, Flemming; Chronakis, Ioannis S; Nielsen, Hanne M.

    In: Molecular Pharmaceutics, Vol. 13, No. 3, 07.03.2016, p. 748-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy. / Christophersen, Philip C.; Birch, Ditlev; Saarinen, Jukka; Isomäki, Antti; Nielsen, Hanne M.; Yang, Mingshi; Strachan, Clare J.; Mu, Huiling.

    In: Journal of Controlled Release, Vol. 197, 10.01.2015, p. 111-120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites. / Schmidt, Marianne Molander; Stærk, Dan; Nielsen, Hanne Mørck; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; Van Staden, Johannes; Jäger, Anna.

    In: Journal of Ethnopharmacology, Vol. 165, 2015, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites. / Schmidt, Marianne Molander; Stærk, Dan; Nielsen, Hanne Mørck; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; Van Staden, Johannes; Jäger, Anna.

    In: Journal of Ethnopharmacology, Vol. 165, 2015, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems. / Madsen, Henriette Baun; Arboe-Andersen, Helle M.; Rozlosnik, Noemi; Madsen, Flemming; Ifversen, Peter; Kasimova, Marina Robertovna; Nielsen, Hanne Mørck.

    In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1798, 2010, p. 1779-1789.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems. / Madsen, Henriette Baun; Arboe-Andersen, Helle M.; Rozlosnik, Noemi; Madsen, Flemming; Ifversen, Peter; Kasimova, Marina Robertovna; Nielsen, Hanne Mørck.

    In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1798, 2010, p. 1779-1789.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems. / Madsen, Henriette Baun; Arboe-Andersen, Helle M; Rozlosnik, Noemi; Madsen, Flemming; Ifversen, Peter; Kasimova, Marina R; Nielsen, Hanne Mørck.

    In: Biochimica et biophysica acta, Vol. 1798, No. 9, 09.2010, p. 1779-89.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Issues in development of biodrug delivery systems. / Jørgensen, Lene; Frokjaer, Sven; Nielsen, Hanne Mørck.

    Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. CRC Press, 2016. p. 13-25.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  35. Published

    Issues in development of biodrug delivery systems. / Jørgensen, Lene; Frøkjær, Sven; Nielsen, Hanne Mørck.

    Biodrug delivery systems: fundamentals, applications and clinical development. ed. / Mariko Morishita; Kinam Park. New York : Informa Healthcare, 2010. p. 13-25.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  36. Issues in development of biodrug delivery systems. / Jørgensen, Lene; Frøkjær, Sven; Nielsen, Hanne Mørck.

    Biodrug delivery systems: fundamentals, applications and clinical development. ed. / Mariko Morishita; Kinam Park. New York : Informa Healthcare, 2010. p. 13-25.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  37. Published

    Kan nanopartikler bruges i behandlingen af hudsygdomme? / Jensen, Louise Bastholm; Knudsen, Nina Østergaard; Foged, Camilla; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning, Vol. 2010, 2010, p. 10-12.

    Research output: Contribution to journalJournal articleCommunication

  38. Kan nanopartikler bruges i behandlingen af hudsygdomme? / Jensen, Louise Bastholm; Knudsen, Nina Østergaard; Foged, Camilla; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning, Vol. 2010, 2010, p. 10-12.

    Research output: Contribution to journalJournal articleCommunication

  39. Published

    Large-scale biophysical evaluation of protein PEGylation effects : in vitro properties of 61 protein entities. / Vernet, Erik; Popa, Gina; Pozdnyakova, Irina; Rasmussen, Jakob Ewald; Grohganz, Holger; Giehm, Lise; Jensen, Malene Hillerup; Wang, Huabing; Plesner, Bitten; Nielsen, Hanne Mørck; Jensen, Knud Jørgen; Berthelsen, Jens; Sundström, Michael; van de Weert, Marco.

    In: Molecular Pharmaceutics, Vol. 13, No. 5, 2016, p. 1587-1598.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms. / Wan, Feng; Nylander, Tommy; Klodzinska, Sylvia Natalie; Foged, Camilla; Yang, Mingshi; Baldursdottir, Stefania G; Mørck Nielsen, Hanne.

    In: A C S Applied Materials and Interfaces, Vol. 10, No. 13, 23.02.2018, p. 10678–10687.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies. / Thanki, Kaushik; Thakur, Aneesh; de Groot, A. M.; Geyer, A.; Fraire, Juan; Falkenberg, Emily; Van Eygen, Hannelore; Putteman, Emma; Van Bijnen, Djai C. J.; Zeng, Xianghui; Sami, H.; Gehrig, S. ; Justesen, Sarah; Franzyk, Henrik; Broere, Femke; van Eden, Willem; Sijts, Alice J A M; Ogris, M.; Nielsen, Hanne Mørck; Braeckmans, Kevin; Foged, Camilla.

    2018. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  42. E-pub ahead of print

    Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model. / Jansen, Manon A A; Klausen, Lasse H; Thanki, Kaushik; Lyngsø, Jeppe; Skov Pedersen, Jan; Franzyk, Henrik; Nielsen, Hanne M; van Eden, Willem; Dong, Mingdong; Broere, Femke; Foged, Camilla; Zeng, Xianghui.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 11.06.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test. / Foged, Camilla; Nielsen, Hanne Mørck; Frøkjær, Sven.

    In: Internation Journal of Pharmaceutics, Vol. 331, No. 2, 2007, p. 160-166.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test. / Foged, Camilla; Nielsen, Hanne Mørck; Frøkjær, Sven.

    In: Internation Journal of Pharmaceutics, Vol. 331, No. 2, 2007, p. 160-166.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line. / Water, Jorrit Jeroen; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  46. Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line. / Water, Jorrit Jeroen; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  47. Published
  48. Published

    MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model. / Te Boekhorst, Bernard C M; Jensen, Linda B; Colombo, Stefano; Varkouhi, Amir K; Schiffelers, Raymond M; Lammers, Twan; Storm, Gert; Nielsen, Hanne M; Strijkers, Gustav J; Foged, Camilla; Nicolay, Klaas.

    In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 161, No. 3, 2012, p. 772-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. E-pub ahead of print

    Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. / Thanki, Kaushik; van Eetvelde, Delphine; Geyer, Antonia; Fraire, Juan; Hendrix, Remi; Van Eygen, Hannelore; Putteman, Emma; Sami, Haider; de Souza Carvalho-Wodarz, Cristiane; Franzyk, Henrik; Nielsen, Hanne Mørck; Braeckmans, Kevin; Lehr, Claus-Michael; Ogris, Manfred; Foged, Camilla.

    In: Journal of controlled release : official journal of the Controlled Release Society, 06.08.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles. / Colombo, Stefano; Cun, Dongmei; Remaut, Katrien; Bunker, Matt; Zhang, Jianxin; Martin-Bertelsen, Birte; Yaghmur, Anan; Braeckmans, Kevin; Nielsen, Hanne M; Foged, Camilla.

    In: Journal of Controlled Release, Vol. 201, 10.03.2015, p. 22-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1299091