Hanne Mørck Nielsen

Hanne Mørck Nielsen

Professor


  1. Published

    Immunogenicity Testing of Lipidoids In Vitro and In Silico : Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design. / de Groot, Anne Marit; Thanki, Kaushik; Gangloff, Monique; Falkenberg, Emily; Zeng, Xianghui; van Bijnen, Djai C J; van Eden, Willem; Franzyk, Henrik; Nielsen, Hanne M; Broere, Femke; Gay, Nick J; Foged, Camilla; Sijts, Alice J A M.

    In: Molecular Therapy - Nucleic Acids, Vol. 11, 01.06.2018, p. 159-169.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro. / Zeng, Xianghui; de Groot, A. M.; Sijts, Alice; Blenke, E. O.; Colombo, Stefano; van Eden, W; Franzyk, Henrik; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Nanoscale, Vol. 7, No. 46, 2015, p. 19687-19698.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA. / Zeng, Xianghui; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    2017. Abstract from 2nd Gazi Pharma Symposium Series, Ankara, Turkey.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  4. Published

    Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration. / Wen, Yanhong; Grøndahl, Lisbeth; Gallego, Monica R.; Jørgensen, Lene; Møller, Eva Horn; Nielsen, Hanne Mørck.

    In: Biomacromolecules, Vol. 13, 2012, p. 905-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Biodegradable nanocomposite microparticles as drug delivering injectable cell scaffolds. / Wen, Yanhong; Gallego, Monica Ramos; Nielsen, Lene Feldskov; Jørgensen, Lene; Everland, Hanne; Møller, Eva Horn; Nielsen, Hanne Mørck.

    In: Journal of Controlled Release, Vol. 156, No. 1, 2011, p. 11-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Design and characterization of core-shell mPEG-PLGA composite microparticles for development of cell-scaffold constructs. / Wen, Yanhong; Gallego, Monica Ramos; Nielsen, Lene Feldskov; Jorgensen, Lene; Møller, Eva Horn; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 85, No. 1, 09.2013, p. 87-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration. / Wen, Yanhong; Grøndahl, Lisbeth; Gallego, Monica R.; Jørgensen, Lene; Møller, Eva Horn; Nielsen, Hanne Mørck.

    In: Biomacromolecules, Vol. 13, 2012, p. 905-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Biodegradable nanocomposite microparticles as drug delivering injectable cell scaffolds. / Wen, Yanhong; Gallego, Monica Ramos; Nielsen, Lene Feldskov; Jørgensen, Lene; Everland, Hanne; Møller, Eva Horn; Nielsen, Hanne Mørck.

    In: Journal of Controlled Release, Vol. 156, No. 1, 2011, p. 11-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line. / Water, Jorrit Jeroen; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  10. Published

    Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line. / Water, Jorrit Jeroen; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  11. Published

    Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics. / Water, Jorrit Jeroen; Maltesen, Morten Jonas; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  12. Published

    Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells. / Water, Jorrit Jeroen; Smart, Simon; Franzyk, Henrik; Foged, Camilla; Nielsen, Hanne Mørck.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 92, 18.02.2015, p. 65-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Three-Dimensional Printing of Drug-Eluting Implants : Preparation of an Antimicrobial Polylactide Feedstock Material. / Water, Jorrit Jeroen; Bohr, Adam; Bøtker, Johan Peter; Aho, Johanna; Sandler, Niklas; Nielsen, Hanne Mørck; Rantanen, Jukka.

    In: Journal of Pharmaceutical Sciences, 15.01.2015, p. 1099–1107.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics. / Water, Jorrit Jeroen; Maltesen, Morten Jonas; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  15. Published

    Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin. / Water, Jorrit J; Kim, YongTae; Maltesen, Morten J; Franzyk, Henrik; Foged, Camilla; Nielsen, Hanne M.

    In: Pharmaceutical Research, Vol. 32, No. 8, 08.2015, p. 2727-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms. / Wan, Feng; Nylander, Tommy; Klodzinska, Sylvia Natalie; Foged, Camilla; Yang, Mingshi; Baldursdottir, Stefania G; Mørck Nielsen, Hanne.

    In: A C S Applied Materials and Interfaces, Vol. 10, No. 13, 23.02.2018, p. 10678–10687.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring. / Wan, Feng; Nylander, Tommy; Foged, Camilla; Yang, Mingshi; Baldursdottir, Stefania G; Nielsen, Hanne M.

    In: Journal of Colloid and Interface Science, Vol. 545, 01.03.2019, p. 162-171.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Large-scale biophysical evaluation of protein PEGylation effects : in vitro properties of 61 protein entities. / Vernet, Erik; Popa, Gina; Pozdnyakova, Irina; Rasmussen, Jakob Ewald; Grohganz, Holger; Giehm, Lise; Jensen, Malene Hillerup; Wang, Huabing; Plesner, Bitten; Nielsen, Hanne Mørck; Jensen, Knud Jørgen; Berthelsen, Jens; Sundström, Michael; van de Weert, Marco.

    In: Molecular Pharmaceutics, Vol. 13, No. 5, 2016, p. 1587-1598.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats. / Vargas Christensen, Isabell; Loftager, Mette; Rode, Frederik; Mørck Nielsen, Hanne; Kreilgaard, Mads; Larsen, Malte Selch.

    In: Journal of Thrombosis and Haemostasis, Vol. 17, No. 6, 2019, p. 964-974.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models. / Tréhin, Rachel; Krauss, Ulrike; Beck-Sickinger, Annette G; Merkle, Hans P; Nielsen, Hanne Mørck.

    In: Pharmaceutical Research, Vol. 21, No. 7, 2004, p. 1248-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Metabolic cleavage of cell-penetrating peptides in contact with epithelial models : human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58). / Tréhin, Rachel; Nielsen, Hanne Mørck; Jahnke, Heinz-Georg; Krauss, Ulrike; Beck-Sickinger, Annette G.; Merkle, Hans P.

    In: Biochemical Journal, Vol. 382, No. Pt 3, 2004, p. 945-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies. / Thanki, Kaushik; Thakur, Aneesh; de Groot, A. M.; Geyer, A.; Fraire, Juan; Falkenberg, Emily; Van Eygen, Hannelore; Putteman, Emma; Van Bijnen, Djai C. J.; Zeng, Xianghui; Sami, H.; Gehrig, S. ; Justesen, Sarah; Franzyk, Henrik; Broere, Femke; van Eden, Willem; Sijts, Alice J A M; Ogris, M.; Nielsen, Hanne Mørck; Braeckmans, Kevin; Foged, Camilla.

    2018. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  23. Published

    Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs. / Thanki, Kaushik; Zeng, Xianghui; Justesen, Sarah; Tejlmann, Sarah; Falkenberg, Emily; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    2017. Poster session presented at 6th FIP Pharmaceutical Sciences World Congress (PSWC), Stockholm, Sweden.

    Research output: Contribution to conferencePosterResearch

  24. E-pub ahead of print

    Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. / Thanki, Kaushik; van Eetvelde, Delphine; Geyer, Antonia; Fraire, Juan; Hendrix, Remi; Van Eygen, Hannelore; Putteman, Emma; Sami, Haider; de Souza Carvalho-Wodarz, Cristiane; Franzyk, Henrik; Nielsen, Hanne Mørck; Braeckmans, Kevin; Lehr, Claus-Michael; Ogris, Manfred; Foged, Camilla.

    In: Journal of controlled release : official journal of the Controlled Release Society, 06.08.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking. / Thanki, Kaushik; Geyer, A.; Zeng, Xianghui; Sami, H.; Gehrig, S. ; Justesen, Sarah; Franzyk, Henrik; Ogris, M.; Nielsen, Hanne Mørck; Foged, Camilla.

    2016. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences (AAPS) 2016, Denver, United States.

    Research output: Contribution to conferencePosterResearch

  26. Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking. / Thanki, Kaushik; Geyer, A.; Zeng, Xianghui; Sami, H.; Gehrig, S.; Justesen, Sarah; Franzyk, Henrik; Ogris, M.; Nielsen, Hanne Mørck; Foged, Camilla.

    2016. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences (AAPS) 2016, Denver, United States.

    Research output: Contribution to conferencePosterResearch

  27. Published

    Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach. / Thanki, Kaushik; Zeng, Xianghui; Justesen, Sarah; Tejlmann, Sarah; Falkenberg, Emily; Van Driessche, Elize; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 120, 11.2017, p. 22-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model. / Te Boekhorst, Bernard C M; Jensen, Linda B; Colombo, Stefano; Varkouhi, Amir K; Schiffelers, Raymond M; Lammers, Twan; Storm, Gert; Nielsen, Hanne M; Strijkers, Gustav J; Foged, Camilla; Nicolay, Klaas.

    In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 161, No. 3, 2012, p. 772-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Cyclodextrins : efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems. / Stojanov, Mladen; Nielsen, Hanne Mørck; Larsen, Kim Lambertsen.

    In: International Journal of Pharmaceutics, Vol. 422, No. 1-2, 2012, p. 349-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Cyclodextrins : efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems. / Stojanov, Mladen; Nielsen, Hanne Mørck; Larsen, Kim Lambertsen.

    In: International Journal of Pharmaceutics, Vol. 422, No. 1-2, 2012, p. 349-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers. / Stie, Mai Bay; Jones, Megan; Sørensen, Henning Osholm; Jacobsen, Jette; Chronakis, Ioannis S. ; Nielsen, Hanne Mørck.

    In: Carbohydrate Polymers, Vol. 215, 01.07.2019, p. 253-262.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Bioactive protein-based nanofibers interact with intestinal biological components resulting in transepithelial permeation of a therapeutic protein. / Stephansen, Karen; García-Díaz, María; Jessen, Flemming; Chronakis, Ioannis S; Nielsen, Hanne Mørck.

    In: International Journal of Pharmaceutics, Vol. 495, No. 1, 10.11.2015, p. 58-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Interactions between Surfactants in Solution and Electrospun Protein Fibers : Effects on Release Behavior and Fiber Properties. / Stephansen, Karen; García-Díaz, María; Jessen, Flemming; Chronakis, Ioannis S; Nielsen, Hanne M.

    In: Molecular Pharmaceutics, Vol. 13, No. 3, 07.03.2016, p. 748-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Novel Silicone Composite for Prolonged Release of Antimicrobial Peptides. / Steffensen, Søren Langer; Møller, Eva Horn; Franzyk, Henrik; Jensen, Minna Grønning; Alm, Martin; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  35. Silicone embedded nanogels for prolonged resistance against biofilm formation. / Steffensen, Søren Langer; Vestergaard, M. H.; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  36. Published

    Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices. / Steffensen, Søren Langer; Merete H., Vestergaard,; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, 2015, p. 305-311.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices. / Steffensen, Søren Langer; Merete H., Vestergaard,; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, 2015, p. 305-311.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Novel Silicone Composite for Prolonged Release of Antimicrobial Peptides. / Steffensen, Søren Langer; Møller, Eva Horn; Franzyk, Henrik; Jensen, Minna Grønning; Alm, Martin; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  39. Published

    Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices. / Steffensen, Søren Langer; Merete H., Vestergaard,; Møller, Eva Horn; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials, Vol. 104, No. 2, 2016, p. 402-410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Silicone embedded nanogels for prolonged resistance against biofilm formation. / Steffensen, Søren Langer; Vestergaard, M. H.; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  41. Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites. / Schmidt, Marianne Molander; Stærk, Dan; Nielsen, Hanne Mørck; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; Van Staden, Johannes; Jäger, Anna.

    In: Journal of Ethnopharmacology, Vol. 165, 2015, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites. / Schmidt, Marianne Molander; Stærk, Dan; Nielsen, Hanne Mørck; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; Van Staden, Johannes; Jäger, Anna.

    In: Journal of Ethnopharmacology, Vol. 165, 2015, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration. / Sander, Camilla; Madsen, Katrine Dragsbæk; Hyrup, Birgitte; Nielsen, Hanne Mørck; Rantanen, Jukka; Jacobsen, Jette.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 85, No. 3 Pt A, 11.2013, p. 682-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Buccal delivery of metformin : TR146 cell culture model evaluating the use of bioadhesive chitosan discs for drug permeability enhancement. / Sander, Camilla; Nielsen, Hanne Mørck; Jacobsen, Jette.

    In: International Journal of Pharmaceutics, Vol. 458, No. 2, 31.12.2013, p. 254-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro. / Rønholt, Stine; Kristensen, Mie; Nielsen, Hanne Mørck.

    Cell-penetrating peptides : Methods and Protocols. ed. / Ülo Langel. Vol. 1324 2015. p. 261-277.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  46. Published

    Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement. / Rune Jørgensen, Jacob; Leth Jepsen, Morten; Hagner Nielsen, Line; Dufva, Martin; Mørck Nielsen, Hanne; Rades, Thomas; Boisen, Anja; Müllertz, Anette.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 143, 2019, p. 98-105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages. / Priemel, Petra A.; Wang, Yingya; Bohr, Adam; Water, Jorrit J.; Yang, Mingshi; Nielsen, Hanne Morck.

    In: Journal of Pharmacy and Pharmacology, Vol. 70, No. 8, 08.2018, p. 1009-1021.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    The potential of chitosan in enhancing peptide and protein absorption across the TR146 cell culture model-an in vitro model of the buccal epithelium. / Portero, Ana; Remuñán-López, Carmen; Nielsen, Hanne Mørck.

    In: Pharmaceutical Research, Vol. 19, No. 2, 2002, p. 169-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Structure of immune stimulating complex matrices and immune stimulating complexes in suspension determined by small-angle X-ray scattering. / Pedersen, Jan Skov; Oliveira, Cristiano Luis Pinto De; Madsen, Henriette Baun; Arleth, Lise; Manniche, Søren; Kirkby, Nicolai ; Nielsen, Hanne Mørck.

    In: Biophysical Journal, Vol. 102, No. 10, 2012, p. 2372-2380.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Antimicrobial, hemolytic, and cytotoxic activities of ß-peptoid-peptide hybrid oligomers : Improved properties compared to natural AMPs. / Olsen, Christian Adam; Ziegler, Hanne Lindvig; Nielsen, Hanne Mørck; Frimodt-Møller, Niels; Jaroszewski, Jerzy W; Franzyk, Henrik.

    In: ChemBioChem, Vol. 11, No. 10, 2010, p. 1356-1360.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Immunity by formulation design : induction of high CD8+ T-cell responses by poly (I:C) incorporated into the CAF01 adjuvant via a double emulsion method. / Nordly, Pernille Juul; Rose, Fabrice; Christensen, Dennis; Nielsen, Hanne Mørck; Andersen, Peter; Agger, Else Marie; Foged, Camilla.

    In: Journal of Controlled Release, Vol. 150, No. 3, 2011, p. 307-317.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo. / Nordly, Pernille Juul; Korsholm, Karen Smith; Pedersen, Esra Alici; Khilji, Tayba Sajid; Franzyk, Henrik; Jørgensen, Lene; Nielsen, Hanne Mørck; Agger, Else Marie; Foged, Camilla.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 77, No. 1, 2011, p. 89-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Modulation of the adjuvant activity of DDA/TDB liposomes with immunostimulators. / Nordly, Pernille Juul; Foged, Camilla; Christensen, D.; Lindenstrøm, T.; Nielsen, Hanne Mørck; Agger, E.

    2010. Poster session presented at  36th Annual Meeting & Exposition of the controlled release society - Innovation in discovery, Copenhagen, Denmark.

    Research output: Contribution to conferencePosterResearch

  54. Published

    Innovativt nanopartikeldesign bag skræddersyede vacciner. / Nordly, Pernille Juul; Agger, Else Marie; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Lægemiddelforskning, 2009, p. 19-21.

    Research output: Contribution to journalJournal articleResearch

  55. Published

    Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/DTDB liposomes  : physico-chemical characterization and induction of CD8+ T-Cell responses in vivo. / Nordly, Pernille Juul; Agger, Else Marie; Andersen, Peter; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Pharmaceutical Research, Vol. 28, No. 3, 2011, p. 553-562.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/DTDB liposomes  : physico-chemical characterization and induction of CD8+ T-Cell responses in vivo. / Nordly, Pernille Juul; Agger, Else Marie; Andersen, Peter; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Pharmaceutical Research, Vol. 28, No. 3, 2011, p. 553-562.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators. / Nordly, Pernille Juul; Madsen, Henriette Baun; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Expert Opinion on Drug Delivery, Vol. 6, No. 7, 2009, p. 1-16.

    Research output: Contribution to journalReviewResearch

  58. Innovativt nanopartikeldesign bag skræddersyede vacciner. / Nordly, Pernille Juul; Agger, Else Marie; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Lægemiddelforskning, 2009, p. 19-21.

    Research output: Contribution to journalJournal articleResearch

  59. Published

    A synthetic mycobacterial monomycoloyl glycerol analogue stabilizes DDA liposomes. / Nordly, Pernille Juul; Pedersen, Esra Alici; Khiljii, Tayba Sajiid; Agger, Else Marie; Jørgensen, Lene; Nielsen, Hanne Mørck; Korsholm, Karen Smith; Franzyk, Henrik; Foged, Camilla.

    In: CRS Newsletter, Vol. 27, No. 2, 2010, p. 12.

    Research output: Contribution to journalJournal articleResearch

  60. Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators. / Nordly, Pernille Juul; Madsen, Henriette Baun; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Expert Opinion on Drug Delivery, Vol. 6, No. 7, 2009, p. 1-16.

    Research output: Contribution to journalReviewResearch

  61. Published

    Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo. / Nordly, Pernille Juul; Korsholm, Karen Smith; Pedersen, Esra Alici; Khilji, Tayba Sajid; Franzyk, Henrik; Jørgensen, Lene; Nielsen, Hanne Mørck; Agger, Else Marie; Foged, Camilla.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 77, No. 1, 2011, p. 89-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Modulation of the adjuvant activity of DDA/TDB liposomes with immunostimulators. / Nordly, Pernille Juul; Foged, Camilla; Christensen, D.; Lindenstrøm, T.; Nielsen, Hanne Mørck; Agger, E.

    2010. Poster session presented at  36th Annual Meeting & Exposition of the controlled release society - Innovation in discovery, Copenhagen, Denmark.

    Research output: Contribution to conferencePosterResearch

  63. Immunity by formulation design : induction of high CD8+ T-cell responses by poly (I:C) incorporated into the CAF01 adjuvant via a double emulsion method. / Nordly, Pernille Juul; Rose, Fabrice; Christensen, Dennis; Nielsen, Hanne Mørck; Andersen, Peter; Agger, Else Marie; Foged, Camilla.

    In: Journal of Controlled Release, Vol. 150, No. 3, 2011, p. 307-317.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Drug delivery studies in Caco-2 monolayers. IV. Ethyl glycoside esters as a novel type of absorption enhancers. / Nielsen, Hanne Mørck; Brøndsted, H.; Frøkjær, Sven; Hovgaard, Lars.

    In: STP pharma sciences, 1996, p. 157-161.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    TR146 cells grown on filters as a model of human buccal epithelium : III. Permeability enhancement by different pH values, different osmolality values, and bile salts. / Nielsen, Hanne Mørck; Rassing, M R.

    In: International Journal of Pharmaceutics, Vol. 185, No. 2, 1999, p. 215-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Nicotine permeability across the buccal TR146 cell culture model and porcine buccal mucosa in vitro : effect of pH and concentration. / Nielsen, Hanne Mørck; Rassing, Margrethe Rømer.

    In: European Journal of Pharmaceutical Sciences, Vol. 16, No. 3, 2002, p. 151-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptidomimetics and lipid bilayers. / Nielsen, Hanne Mørck; Jing, Xiaona; Simonsen, A.; Kasimova, Marina Robertovna; Malmsten, M.; Franzyk, Henrik; Foged, Camilla.

    In: Journal of Peptide Science, Vol. 16, No. s1, 2010, p. 151.

    Research output: Contribution to journalConference abstract in journalResearch

  68. Published

    Biologiske lægemidler - fra molekyle til medicin. / Nielsen, Hanne Mørck; Foged, Camilla; Jørgensen, Lene; Frøkjær, Sven.

    In: Lægemiddelforskning, 2013, p. 12-14.

    Research output: Contribution to journalJournal articleResearch

  69. Published

    Effect of oil-in-water emulsions on 5-aminolevulinic acid uptake and metabolism to PpIX in cultured MCF-7 cells. / Nielsen, Hanne Mørck; Aemisegger, Caroline; Burmeister, Gerd; Schuchter, Ursula; Gander, Bruno.

    In: Pharmaceutical Research, Vol. 21, No. 12, 2004, p. 2253-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Biologiske lægemidler - fra molekyle til medicin. / Nielsen, Hanne Mørck; Foged, Camilla; Jørgensen, Lene; Frøkjær, Sven.

    In: Lægemiddelforskning, 2013, p. 12-14.

    Research output: Contribution to journalJournal articleResearch

  71. Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptidomimetics and lipid bilayers. / Nielsen, Hanne Mørck; Jing, Xiaona; Simonsen, A.; Kasimova, Marina Robertovna; Malmsten, M.; Franzyk, Henrik; Foged, Camilla.

    In: Journal of Peptide Science, Vol. 16, No. s1, 2010, p. 151.

    Research output: Contribution to journalConference abstract in journalResearch

  72. Published

    TR146 cells grown on filters as a model of human buccal epithelium : permeability of fluorescein isothiocyanate-labelled dextrans in the presence of sodium glycocholate. / Nielsen, Hanne Mørck; Verhoef, J C; Ponec, M; Rassing, M R.

    In: Journal of Controlled Release, Vol. 60, No. 2-3, 1999, p. 223-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Drug delivery studies in Caco-2 monolayers. IV. Ethyl glycoside esters as a novel type of absorption enhancers. / Nielsen, Hanne Mørck; Brøndsted, H. ; Frøkjær, Sven; Hovgaard, Lars.

    In: STP pharma sciences, 1996, p. 157-161.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    TR146 cells grown on filters as a model of human buccal epithelium : IV. Permeability of water, mannitol, testosterone and beta-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa. / Nielsen, H M; Rassing, M R; Nielsen, Hanne Mørck.

    In: International Journal of Pharmaceutics, Vol. 194, No. 2, 2000, p. 155-67.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    TR146 cells grown on filters as a model of human buccal epithelium : V. Enzyme activity of the TR146 cell culture model, human buccal epithelium and porcine buccal epithelium, and permeability of leu-enkephalin. / Mørck Nielsen, H; Rømer Rassing, M; Nielsen, Hanne Mørck.

    In: International Journal of Pharmaceutics, Vol. 200, No. 2, 2000, p. 261-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Quantification of pharmaceutical peptides in human plasma by LC-ICP-MS sulfur detection. / Møller, Laura Hyrup; Macherius, André; Hansen, Thomas Hesselhøj; Nielsen, Hanne Mørck; Cornett, Claus; Østergaard, Jesper; Stürup, Stefan; Gammelgaard, Bente.

    In: Journal of Analytical Atomic Spectrometry, Vol. 31, 2016, p. 1877-1884.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Gendannelse af ødelagt væv med stamceller. / Møller, Eva Horn; Wen, Yanhong; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning, Vol. 2011, 12.2011, p. 13-15.

    Research output: Contribution to journalJournal articleCommunication

  78. Gendannelse af ødelagt væv med stamceller. / Møller, Eva Horn; Wen, Yanhong; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning, Vol. 2011, 12.2011, p. 13-15.

    Research output: Contribution to journalJournal articleCommunication

  79. Published
  80. Published

    Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients. / Molchanova, Natalia; Wang, Hengzhuang; Hansen, Paul R; Høiby, Niels; Nielsen, Hanne M; Franzyk, Henrik.

    In: Frontiers in Microbiology, Vol. 10, 275, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Interaction of Laponite with Membrane Components-Consequences for Bacterial Aggregation and Infection Confinement. / Malekkhaiat Häffner, Sara; Nyström, Lina; Browning, Kathryn L; Mörck Nielsen, Hanne; Strömstedt, Adam A; van der Plas, Mariena J A; Schmidtchen, Artur; Malmsten, Martin.

    In: A C S Applied Materials and Interfaces, Vol. 11, No. 17, 01.05.2019, p. 15389-15400.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    In Vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum. / Madsen, Henriette Baun; Ifversen, Peter; Madsen, Flemming; Larsen, Birger Brodin; Hausser, Ingrid; Nielsen, Hanne Mørck.

    In: The AAPS Journal, Vol. 11, No. 4, 2009, p. 728-739.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems. / Madsen, Henriette Baun; Arboe-Andersen, Helle M.; Rozlosnik, Noemi; Madsen, Flemming; Ifversen, Peter; Kasimova, Marina Robertovna; Nielsen, Hanne Mørck.

    In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1798, 2010, p. 1779-1789.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Farvel til sprøjten : udvikling af vaccineplaster med nanopartikler. / Madsen, Henriette Baun; Ifversen, Peter; Madsen, Flemming; Manniche, Søren; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning, 2007, p. 12-13.

    Research output: Contribution to journalJournal articleCommunication

  85. Published

    Farvel til sprøjten : udvikling af vaccineplaster med nanopartikler. / Madsen, Henriette Baun; Ifversen, Peter; Madsen, Flemming; Manniche, Søren; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning, 2007, p. 12-13.

    Research output: Contribution to journalJournal articleCommunication

  86. In Vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum. / Madsen, Henriette Baun; Ifversen, Peter; Madsen, Flemming; Larsen, Birger Brodin; Hausser, Ingrid; Nielsen, Hanne Mørck.

    In: The AAPS Journal, Vol. 11, No. 4, 2009, p. 728-739.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems. / Madsen, Henriette Baun; Arboe-Andersen, Helle M; Rozlosnik, Noemi; Madsen, Flemming; Ifversen, Peter; Kasimova, Marina R; Nielsen, Hanne Mørck.

    In: Biochimica et biophysica acta, Vol. 1798, No. 9, 09.2010, p. 1779-89.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems. / Madsen, Henriette Baun; Arboe-Andersen, Helle M.; Rozlosnik, Noemi; Madsen, Flemming; Ifversen, Peter; Kasimova, Marina Robertovna; Nielsen, Hanne Mørck.

    In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1798, 2010, p. 1779-1789.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Innovative Methods and Applications in Mucoadhesion Research. / Mackie, Alan R; Goycoolea, Francisco M; Menchicchi, Bianca; Caramella, Carla Marcella; Saporito, Francesca; Lee, Seunghwan; Stephansen, Karen; Chronakis, Ioannis S; Hiorth, Marianne; Adamczak, Malgorzata; Waldner, Max; Nielsen, Hanne Mørck; Marcelloni, Luciano.

    In: Macromolecular Bioscience, Vol. 17, No. 8, 1600534, 08.2017.

    Research output: Contribution to journalReviewResearchpeer-review

  90. Published

    Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing. / Liu, Xiaoli; Nielsen, Line Hagner; Klodzinska, Sylvia Natalie; Nielsen, Hanne Mørck; Qu, Haiyan; Christensen, Lars Porskjær; Rantanen, Jukka; Yang, Mingshi.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 123, 02.2018, p. 42-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    The impact of particle preparation methods and polymorphic stability of lipid excipients on protein distribution in microparticles. / Liu, Jingying; Christophersen, Philip C; Yang, Mingshi; Nielsen, Hanne M; Mu, Huiling.

    In: Drug Development and Industrial Pharmacy, Vol. 43, No. 12, 12.2017, p. 2032-2042.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Self-nanoemulsifying drug delivery systems for oral insulin delivery : In vitro and in vivo evaluations of enteric coating and drug loading. / Li, Ping; Tan, Angel; Prestidge, Clive A; Nielsen, Hanne Mørck; Müllertz, Anette.

    In: International Journal of Pharmaceutics, Vol. 477, No. 1-2, 30.12.2014, p. 390-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Oral delivery of peptides and proteins using lipid-based drug delivery systems. / Li, Ping; Nielsen, Hanne Mørck; Müllertz, Anette.

    In: Expert Opinion on Drug Delivery, Vol. 9, No. 10, 2012, p. 1289-304.

    Research output: Contribution to journalReviewResearchpeer-review

  94. Published

    Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers. / Li, Ping; Nielsen, Hanne Mørck; Müllertz, Anette.

    In: Journal of Pharmaceutical Sciences, Vol. 105, No. 9, 09.2016, p. 2743-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems. / Li, Ping; Nielsen, Hanne Mørck; Fano, Mathias; Müllertz, Anette.

    In: Journal of Pharmaceutical Sciences, Vol. 102, No. 8, 08.2013, p. 2689-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic. / Kłodzińska, Sylvia Natalie; Molchanova, Natalia; Franzyk, Henrik; Hansen, Paul Robert; Damborg, Peter; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 128, 07.2018, p. 1-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5. / Kłodzińska, Sylvia N.; Pletzer, Daniel; Rahanjam, Negin; Rades, Thomas; Hancock, Robert E.W.; Nielsen, Hanne M.

    In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 20, 102022, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH. / Kristensen, Mie; Nielsen, Line Hagner; Zor, Kinga; Boisen, Anja; Christensen, Malene Vinther; Berthelsen, Jens; Nielsen, Hanne Mørck.

    In: Bioconjugate Chemistry, Vol. 29, No. 2, 2018, p. 371-381.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Reversible tight junction modulation using an enterotoxin-derived peptide as enhancer for delivery of biopharmaceuticals across biobarriers. / Kristensen, Mie; Nielsen, Hanne Mørck.

    2015. Poster session presented at Crossing Biological Barriers, Dresden, Germany.

    Research output: Contribution to conferencePosterResearchpeer-review

  100. Published

    Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos. / Kristensen, Mie; Birch, Ditlev; Mørck Nielsen, Hanne.

    In: International Journal of Molecular Sciences , Vol. 17, No. 2, 185, 30.01.2016, p. 1-17.

    Research output: Contribution to journalReviewResearchpeer-review

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