Hanne Mørck Nielsen

Hanne Mørck Nielsen

Professor


  1. 2016
  2. Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking. / Thanki, Kaushik; Geyer, A.; Zeng, Xianghui; Sami, H.; Gehrig, S.; Justesen, Sarah; Franzyk, Henrik; Ogris, M.; Nielsen, Hanne Mørck; Foged, Camilla.

    2016. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences (AAPS) 2016, Denver, United States.

    Research output: Contribution to conferencePosterResearch

  3. Published

    Large-scale biophysical evaluation of protein PEGylation effects : in vitro properties of 61 protein entities. / Vernet, Erik; Popa, Gina; Pozdnyakova, Irina; Rasmussen, Jakob Ewald; Grohganz, Holger; Giehm, Lise; Jensen, Malene Hillerup; Wang, Huabing; Plesner, Bitten; Nielsen, Hanne Mørck; Jensen, Knud Jørgen; Berthelsen, Jens; Sundström, Michael; van de Weert, Marco.

    In: Molecular Pharmaceutics, Vol. 13, No. 5, 2016, p. 1587-1598.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2015
  5. Published

    Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections. / Bahnsen, Jesper S; Franzyk, Henrik; Sayers, Edward J; Jones, Arwyn T; Nielsen, Hanne M.

    In: Pharmaceutical Research, Vol. 32, No. 5, 2015, p. 1546-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Intact penetratin metabolite permeates across Caco-2 monolayers. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2015. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences, Orlando, Florida, United States.

    Research output: Contribution to conferencePosterResearch

  7. Intact penetratin metabolite permeates across Caco-2 monolayers. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2015. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences, Orlando, Florida, United States.

    Research output: Contribution to conferencePosterResearch

  8. Published

    Mucus as a Barrier to Drug Delivery : Understanding and Mimicking the Barrier Properties. / Bøgh, Marie; Nielsen, Hanne Mørck.

    In: Basic & Clinical Pharmacology & Toxicology, Vol. 116, No. 3, 03.2015, p. 179-186.

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation. / Bøgh, Marie; García-Díaz, María; Müllertz, Anette; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, No. Part A, 09.2015, p. 136–143.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy. / Christophersen, Philip C.; Birch, Ditlev; Saarinen, Jukka; Isomäki, Antti; Nielsen, Hanne M.; Yang, Mingshi; Strachan, Clare J.; Mu, Huiling.

    In: Journal of Controlled Release, Vol. 197, 10.01.2015, p. 111-120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs. / Christophersen, Philip Carsten; Fano, Mathias; Saaby, Lasse; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling.

    In: Current Pharmaceutical Design, Vol. 21, No. 19, 2015, p. 2611-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles. / Colombo, Stefano; Cun, Dongmei; Remaut, Katrien; Bunker, Matt; Zhang, Jianxin; Martin-Bertelsen, Birte; Yaghmur, Anan; Braeckmans, Kevin; Nielsen, Hanne M; Foged, Camilla.

    In: Journal of Controlled Release, Vol. 201, 10.03.2015, p. 22-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Improved insulin loading in poly (lactic-co-glycolic) acid (PLGA) nanoparticles upon self-assembly with lipids. / Garcia Diaz, Maria; Foged, Camilla; Nielsen, Hanne Mørck.

    In: International Journal of Pharmaceutics, Vol. 482, 2015, p. 84-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Antimicrobial activity of GN peptides and their mode of action. / Godballe, Troels; Mojsoska, Biljana; Nielsen, Hanne M; Jenssen, Håvard.

    In: Biopolymers, Vol. 106, No. 2, 13.12.2015, p. 172–183.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Selenium as an alternative peptide label - comparison to fluorophore-labelled penetratin. / Hyrup Møller, Laura; Bahnsen, Jesper Søborg; Nielsen, Hanne Mørck; Østergaard, Jesper; Stürup, Stefan; Gammelgaard, Bente.

    In: European Journal of Pharmaceutical Sciences, Vol. 67, 25.01.2015, p. 76-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    End Group Modification : Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria. / Jahnsen, Rasmus O; Sandberg-Schaal, Anne; Frimodt-Møller, Niels; Nielsen, Hanne Mørck; Franzyk, Henrik.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 95, No. Part A, 23.01.2015, p. 40–46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
  18. Published

    Conjugation of a cell-penetrating peptide to parathyroid hormone affects its structure, potency, and transepithelial permeation. / Kristensen, Mie; de Groot, Anne Marit; Berthelsen, Jens; Franzyk, Henrik; Sijts, Alice; Nielsen, Hanne Mørck.

    In: Bioconjugate Chemistry, Vol. 26, 2015, p. 477-488.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation. / Kristensen, Mie; Franzyk, Henrik; Klausen, M. T.; Iversen, A; Bahnsen, Jesper Søborg; Skyggebjerg, R. B.; Foderà, Vito; Nielsen, Hanne Mørck.

    In: A A P S Journal, Vol. 17, No. 5, 2015, p. 1200-1209.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation. / Kristensen, Mie; Franzyk, Henrik; Klausen, M. T. ; Iversen, A; Bahnsen, Jesper Søborg; Skyggebjerg, R. B.; Foderà, Vito; Nielsen, Hanne Mørck.

    In: A A P S Journal, Vol. 17, No. 5, 2015, p. 1200-1209.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Penetratin-mediated transepithelial insulin pemeation: Importance of complexation? / Kristensen, Mie; Foderà, Vito; Nielsen, Hanne Mørck.

    2015.

    Research output: Contribution to conferencePosterResearchpeer-review

  22. Published

    Reversible tight junction modulation using an enterotoxin-derived peptide as enhancer for delivery of biopharmaceuticals across biobarriers. / Kristensen, Mie; Nielsen, Hanne Mørck.

    2015. Poster session presented at Crossing Biological Barriers, Dresden, Germany.

    Research output: Contribution to conferencePosterResearchpeer-review

  23. Reversible tight junction modulation using an enterotoxin-derived peptide as enhancer for delivery of biopharmaceuticals across biobarriers. / Kristensen, Mie; Nielsen, Hanne Mørck.

    2015. Poster session presented at Crossing Biological Barriers, Dresden, Germany.

    Research output: Contribution to conferencePosterResearchpeer-review

  24. Published

    Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro. / Rønholt, Stine; Kristensen, Mie; Nielsen, Hanne Mørck.

    Cell-penetrating peptides : Methods and Protocols. ed. / Ülo Langel. Vol. 1324 2015. p. 261-277.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  25. Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites. / Schmidt, Marianne Molander; Stærk, Dan; Nielsen, Hanne Mørck; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; Van Staden, Johannes; Jäger, Anna.

    In: Journal of Ethnopharmacology, Vol. 165, 2015, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites. / Schmidt, Marianne Molander; Stærk, Dan; Nielsen, Hanne Mørck; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; Van Staden, Johannes; Jäger, Anna.

    In: Journal of Ethnopharmacology, Vol. 165, 2015, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices. / Steffensen, Søren Langer; Merete H., Vestergaard,; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, 2015, p. 305-311.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices. / Steffensen, Søren Langer; Merete H., Vestergaard,; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, 2015, p. 305-311.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Bioactive protein-based nanofibers interact with intestinal biological components resulting in transepithelial permeation of a therapeutic protein. / Stephansen, Karen; García-Díaz, María; Jessen, Flemming; Chronakis, Ioannis S; Nielsen, Hanne Mørck.

    In: International Journal of Pharmaceutics, Vol. 495, No. 1, 10.11.2015, p. 58-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin. / Water, Jorrit J; Kim, YongTae; Maltesen, Morten J; Franzyk, Henrik; Foged, Camilla; Nielsen, Hanne M.

    In: Pharmaceutical Research, Vol. 32, No. 8, 08.2015, p. 2727-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells. / Water, Jorrit Jeroen; Smart, Simon; Franzyk, Henrik; Foged, Camilla; Nielsen, Hanne Mørck.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 92, 18.02.2015, p. 65-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Three-Dimensional Printing of Drug-Eluting Implants : Preparation of an Antimicrobial Polylactide Feedstock Material. / Water, Jorrit Jeroen; Bohr, Adam; Bøtker, Johan Peter; Aho, Johanna; Sandler, Niklas; Nielsen, Hanne Mørck; Rantanen, Jukka.

    In: Journal of Pharmaceutical Sciences, 15.01.2015, p. 1099–1107.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro. / Zeng, Xianghui; de Groot, A. M.; Sijts, Alice; Blenke, E. O.; Colombo, Stefano; van Eden, W; Franzyk, Henrik; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Nanoscale, Vol. 7, No. 46, 2015, p. 19687-19698.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2014
  35. Published

    Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption. / Bøgh, Marie; Baldursdóttir, Stefania G; Müllertz, Anette; Nielsen, Hanne M.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 87, 08.01.2014, p. 227-235.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles. / Christophersen, P.; Vaghela, D.; Müllertz, Anette; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling.

    2014. Abstract from 41st Controlled Release Society (CRS) Annual Meeting, Chicago, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  37. Published

    Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles. / Christophersen, P.; Vaghela, D.; Müllertz, Anette; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling.

    2014. Abstract from 41st Controlled Release Society (CRS) Annual Meeting, Chicago, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  38. Published

    Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin. / Christophersen, Philip C; Vaghela, Dimple; Müllertz, Anette; Yang, Mingshi; Nielsen, Hanne M; Mu, Huiling.

    In: A A P S Journal, Vol. 16, No. 4, 07.2014, p. 875-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation. / Christophersen, Philip Carsten; Zhang, Long; Müllertz, Anette; Nielsen, Hanne Mørck; Yang, Mingshi; Mu, Huiling.

    In: Pharmaceutical Research, Vol. 31, No. 9, 13.03.2014, p. 2420-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    AMP mimics with bactericidal activity against Staphylococci and Pseudomonas as novel drugs for topical use in veterinary medicine. / Greco, Ines; Damborg, Peter Panduro; Guardabassi, Luca; Nielsen, Hanne Mørck; Hansen, Paul Robert.

    2014. Poster session presented at AMP 2014 - 4th International Symposium on Antimicrobial Peptides, LLorient, France.

    Research output: Contribution to conferencePosterResearchpeer-review

  41. AMP mimics with bactericidal activity against Staphylococci and Pseudomonas as novel drugs for topical use in veterinary medicine. / Greco, Ines; Damborg, Peter Panduro; Guardabassi, Luca; Nielsen, Hanne Mørck; Hansen, Paul Robert.

    2014. Poster session presented at AMP 2014 - 4th International Symposium on Antimicrobial Peptides, LLorient, France.

    Research output: Contribution to conferencePosterResearchpeer-review

  42. Published

    The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models. / Ingvarsson, Pall Thor; Rasmussen, Ida Svahn; Viaene, Michelle; Irlik, Przemyslaw Jedrzej; Nielsen, Hanne Mørck; Foged, Camilla.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 87, No. 3, 08.2014, p. 480-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli. / Jahnsen, Rasmus D; Sandberg-Schaal, Anne; Vissing, Karina Juul; Nielsen, Hanne Mørck; Frimodt-Møller, Niels; Franzyk, Henrik.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 7, 20.03.2014, p. 2864-2873.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Characterization of PTH-CPP fusion peptides for oral delivery. / Kristensen, Mie; Berthelsen, Jens; Nielsen, Hanne Mørck.

    2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  45. Published

    Parathyroid hormone coupled to cell-penetrating peptides for oral delivery. / Kristensen, Mie; Nielsen, Hanne Mørck.

    2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  46. Published

    Self-nanoemulsifying drug delivery systems for oral insulin delivery : In vitro and in vivo evaluations of enteric coating and drug loading. / Li, Ping; Tan, Angel; Prestidge, Clive A; Nielsen, Hanne Mørck; Müllertz, Anette.

    In: International Journal of Pharmaceutics, Vol. 477, No. 1-2, 30.12.2014, p. 390-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Silicone embedded nanogels for prolonged resistance against biofilm formation. / Steffensen, Søren Langer; Vestergaard, M. H.; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  48. Silicone embedded nanogels for prolonged resistance against biofilm formation. / Steffensen, Søren Langer; Vestergaard, M. H.; Jensen, Minna Grønning; Alm, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  49. Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics. / Water, Jorrit Jeroen; Maltesen, Morten Jonas; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  50. Published

    Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics. / Water, Jorrit Jeroen; Maltesen, Morten Jonas; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2014. Poster session presented at Controlled Release Society Annual Meeting 2014, Chicago, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  51. 2013
  52. Published

    Antimicrobial and cell-penetrating properties of penetratin analogs : effect of sequence and secondary structure. / Bahnsen, Jesper Søborg; Franzyk, Henrik; Sandberg-Schaal, Anne; Nielsen, Hanne Mørck.

    In: B B A - Biomembranes, Vol. 1828, No. 2, 2013, p. 223-232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Cell-penetrating Peptides Targeting Intracellular Infections. / Bahnsen, Jesper Søborg; Franzyk, Henrik; Sandberg-Schaal, Anne; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  54. Cell-penetrating Peptides Targeting Intracellular Infections. / Bahnsen, Jesper Søborg; Franzyk, Henrik; Sandberg-Schaal, Anne; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

ID: 1299091