David E. Gloriam

David E. Gloriam

Professor


  1. Published

    An online resource for GPCR structure determination and analysis. / Munk, Christian; Mutt, Eshita; Isberg, Vignir; Nikolajsen, Louise F; Bibbe, Janne M; Flock, Tilman; Hanson, Michael A; Stevens, Raymond C; Deupi, Xavier; Gloriam, David E.

    In: Nature Methods, Vol. 16, No. 2, 2019, p. 151-162.

    Research output: Contribution to journalReviewResearchpeer-review

  2. Published

    Bigger is better in virtual drug screens. / Gloriam, David E.

    In: Nature, Vol. 566, No. 7743, 14.02.2019, p. 193-194.

    Research output: Contribution to journalLetterResearchpeer-review

  3. Published

    Bigger is better in virtual drug screens. / Gloriam, David E.

    In: Nature, Vol. 566, No. 7743, 02.2019, p. 193-194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites. / Krall, Jacob; Bavo, Francesco; Falk-Petersen, Christina B; Jensen, Claus Hatt; Nielsen, Julie Olsson; Tian, Yongsong; Anglani, Valeria; Kongstad, Kenneth Thermann; Piilgaard, Louise; Nielsen, Birgitte; Gloriam, David E; Kehler, Jan; Jensen, Anders A.; Harpsøe, Kasper; Wellendorph, Petrine; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 62, No. 5, 14.03.2019, p. 2798-2813.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Discovery of Human Signaling Systems : Pairing Peptides to G Protein-Coupled Receptors. / Foster, Simon R; Hauser, Alexander S; Vedel, Line; Strachan, Ryan T; Huang, Xi-Ping; Gavin, Ariana C; Shah, Sushrut D; Nayak, Ajay P; Haugaard-Kedström, Linda M; Penn, Raymond B; Roth, Bryan L; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Cell, Vol. 179, No. 4, 31.10.2019, p. 895-908.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. / Giraudo, Alessandro; Krall, Jacob; Bavo, Francesco; Nielsen, Birgitte; Kongstad, Kenneth Thermann; Rolando, Barbara; De Blasio, Rosella; Gloriam, David E; Löffler, Rebekka; Thiesen, Louise; Harpsøe, Kasper; Frydenvang, Karla; Boschi, Donatella; Wellendorph, Petrine; Lolli, Marco L; Jensen, Anders A.; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 62, No. 12, 27.06.2019, p. 5797-5809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. E-pub ahead of print

    G protein-coupled receptor pharmacology-The next generation. / Bräuner-Osborne, Hans; Rosenkilde, Mette M; Gether, Ulrik; Gloriam, David E.

    In: Basic & Clinical Pharmacology & Toxicology, 13.07.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist. / Nøhr, Anne Cathrine; Shehata, Mohamed A; Palmer, Daniel; Pokhrel, Rina; Vallianou, Maria; Foster, Simon R; Gentry, Patrick R; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Scientific Reports, Vol. 9, No. 1, 07.03.2019, p. 3802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. E-pub ahead of print

    Pharmacology and function of the orphan GPR139 G protein-coupled receptor. / Vedel, Line; Nøhr, Anne Cathrine; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Basic & Clinical Pharmacology & Toxicology, 27.05.2019.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Published

    Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands. / Gaiser, Birgit I; Danielsen, Mia; Marcher-Rørsted, Emil; Røpke Jørgensen, Kira; Wróbel, Tomasz M; Frykman, Mikael; Johansson, Henrik; Bräuner-Osborne, Hans; Gloriam, David E; Mathiesen, Jesper Mosolff; Sejer Pedersen, Daniel.

    In: Journal of Medicinal Chemistry, Vol. 62, No. 17, 12.09.2019, p. 7806-7839.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity. / Malfacini, Davide; Patt, Julian; Annala, Suvi; Harpsøe, Kasper; Eryilmaz, Funda; Reher, Raphael; Crüsemann, Max; Hanke, Wiebke; Zhang, Hang; Tietze, Daniel; Gloriam, David E; Bräuner-Osborne, Hans; Strømgaard, Kristian; König, Gabriele M; Inoue, Asuka; Gomeza, Jesus; Kostenis, Evi.

    In: The Journal of Biological Chemistry, Vol. 294, No. 15, 12.04.2019, p. 5747-5758.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Receptor selectivity between the G proteins Gα 12 and Gα 13 is defined by a single leucine-to-isoleucine variation. / Mackenzie, Amanda E.; Quon, Tezz; Lin, Li Chiung; Hauser, Alexander S.; Jenkins, Laura; Inoue, Asuka; Tobin, Andrew B.; Gloriam, David E.; Hudson, Brian D.; Milligan, Graeme.

    In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, No. 4, 01.04.2019, p. 5005-5017.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 5953796