David E. Gloriam

David E. Gloriam

Professor


  1. Published

    3-Substituted 2-phenyl-indoles : Privileged structures for medicinal chemistry. / Johansson, Karl Henrik; Jørgensen, T.B.; Gloriam, D.E.; Bräuner-Osborne, Hans; Pedersen, D.S.

    In: R S C Advances, Vol. 3, No. 3, 21.01.2013, p. 945-960.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. / Peng, Yao; McCorvy, John D.; Harpsøe, Kasper; Lansu, Katherine; Yuan, Shuguang; Popov, Petr; Qu, Lu; Pu, Mengchen; Che, Tao; Nikolajsen, Louise F.; Huang, Xi-ping; Wu, Yiran; Shen, Ling; Bjørn-Yoshimoto, Walden E.; Ding, Kang; Wacker, Daniel; Han, Gye Won; Cheng, Jianjun; Katritch, Vsevolod; Jensen, Anders A.; Hanson, Michael A.; Zhao, Suwen; Gloriam, David E.; Roth, Bryan L.; Stevens, Raymond C.; Liu, Zhi-jie.

    In: Cell, Vol. 172, No. 4, P719-730.E14, 2018, p. 719-730.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A Structural Framework for GPCR Chemogenomics : What’s In a Residue Number? / Vass, Márton; Kooistra, Albert J.; Verhoeven, Stefan; Gloriam, David; de Esch, Iwan J.P.; de Graaf, Chris.

    Methods in Molecular Biology. Humana Press, 2018. p. 73-113 (Methods in Molecular Biology, Vol. 1705).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  4. Published

    A community standard format for the representation of protein affinity reagents. / Gloriam, David Erik Immanuel; Orchard, Sandra; Bertinetti, Daniela; Björling, Erik; Bongcam-Rudloff, Erik; Borrebaeck, Carl A K; Bourbeillon, Julie; Bradbury, Andrew R M; de Daruvar, Antoine; Dübel, Stefan; Frank, Ronald; Gibson, Toby J; Gold, Larry; Haslam, Niall; Herberg, Friedrich W; Hiltke, Tara; Hoheisel, Jörg D; Kerrien, Samuel; Koegl, Manfred; Konthur, Zoltán; Korn, Bernhard; Landegren, Ulf; Montecchi-Palazzi, Luisa; Palcy, Sandrine; Rodriguez, Henry; Schweinsberg, Sonja; Sievert, Volker; Stoevesandt, Oda; Taussig, Michael J; Ueffing, Marius; Uhlén, Mathias; van der Maarel, Silvère; Wingren, Christer; Woollard, Peter; Sherman, David J; Hermjakob, Henning.

    In: Molecular and Cellular Proteomics, Vol. 9, No. 1, 2010, p. 1-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A ligand's view of target similarity : chemogenomic binding site-directed techniques for drug discovery. / Garland, Stephen L; Gloriam, David E.

    In: Current Topics in Medicinal Chemistry, Vol. 11, No. 15, 2011, p. 1872-1881.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors. / Fidom, Kimberley; Isberg, Vignir; Hauser, Alexander Sebastian; Mordalski, Stefan; Lehto, Thomas; Bojarski, Andrzej J; Gloriam, David E.

    In: Methods, Vol. 71, 01.2015, p. 104-112.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment : meeting new challenges. / Kufareva, Irina; Katritch, Vsevolod; Biggin, Phil; Kim, Minsup; Park, Kichul; Jung, Sang Won; Cho, Art E.; Sands, Zara A.; Ostopovici-Halip, Liliana; Bologa, Cristian G.; Norn, Christoffer; Brylinski, Michal; Skolnick, Jeffrey; Keränen, Henrik; Lenselink, Bart E.; Van Westen, Gerard; Overington, John P.; De Teráán, Hugo Gutiérrez; Isberg, Vignir; Fidom, Kimberley M.; Lehto, Thomas M.; Gloriam, David E.; Ghosh, Anirban; Sonavane, Uddhavesh; Joshi, Rajendra; Xia, Jie; Hsieh, Jui Hua; Zhang, Liangren; Wang, Xiang Simon; Vogel, Horst; Yuan, Shuguang; Feng, X.; Chen, M.; Ambia, J.; Barth, P.; Gageat, Cédric; Stepniewski, Michal; Xhaard, Henri; Kelm, Sebastian; Pitt, William R.; Shi, Jiye; Larsen, Adrien; Li, Hubert; Wagner, Jeffrey; Bhattacharya, Supriyo; Vaidehi, Nagarajan; Kanou, Kazuhiko; Cvicek, Vaclav; Kim, Soo Kyung; Trzaskowski, Bartosz; Goddard, William A.; Abrol, Ravinder; Selvam, Balaji; Tikhonova, Irina G.; Cuzzolin, Alberto; Sabbadin, Davide; Ciancetta, Antonella; Moro, Stefano; Freyd, Thibaud; Gabrielsen, Mari; Kristiansen, Kurt; Sylte, Ingebrigt; Gaffney, Kevin J.; Petasis, Nicos A.; Latek, Dorota; Bajda, Marek; Młynarczyk, Krzysztof; Filipek, Sławomir; López, Laura; Kuiper, Michael; Beuming, Thijs; Perez-Aguilar, Jose Manuel; Wang, Ray Yu Ruei; Park, Hahnbeom; Greisen, Per; Song, Yifan; DiMaio, Frank; Baker, David; Shin, Woong Hee; Heo, Lim; Lee, Gyu Rie; Seok, Chaok; Yang, Jianyi; Zhang, Yang; Ponassi, Marco; Rosano, Camillo; Cheremovskiy, Georgy; Grudinin, Sergei; Chaudhari, Rajan; Heim, Andrew J.; Li, Zhijun; Lv, Qiang; Grigorov, Martin G.; Hu, Xin; Sun, Hongmao; Shen, Min; Southall, Noel; Jadhav, Ajit; Rodríguez, David; Ranganathan, Anirudh; Carlsson, Jens; Najmanovich, Rafael; Durdagi, Serdar; De March, Claire; Diharce, Julien; Golebiowski, Jérôme; Antonczak, Serge; Fiorucci, Sébastien; Nguyen, Elizabeth; Meiler, Jens; Gutcaits, Aleksandrs; Marti-Solano, Maria; Pastor, Manuel; Selent, Jana; Stevens, Raymond C.; Abagyan, Ruben.

    In: Structure, Vol. 22, No. 8, 2014, p. 1120-1139.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    An online resource for GPCR structure determination and analysis. / Munk, Christian; Mutt, Eshita; Isberg, Vignir; Nikolajsen, Louise F; Bibbe, Janne M; Flock, Tilman; Hanson, Michael A; Stevens, Raymond C; Deupi, Xavier; Gloriam, David E.

    In: Nature Methods, Vol. 16, No. 2, 02.2019, p. 151-162.

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils. / Christensen, Hanna B; Gloriam, David E; Pedersen, Daniel Sejer; Cowland, Jack B; Borregaard, Niels; Bräuner-Osborne, Hans.

    In: Journal of Pharmacological and Toxicological Methods, Vol. 88, No. Pt 1, 15.07.2017, p. 72-78.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Bigger is better in virtual drug screens. / Gloriam, David E.

    In: Nature, Vol. 566, No. 7743, 14.02.2019, p. 193-194.

    Research output: Contribution to journalLetterResearchpeer-review

  11. Published

    Bigger is better in virtual drug screens. / Gloriam, David E.

    In: Nature, Vol. 566, No. 7743, 02.2019, p. 193-194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene. / Molck, C.; Harpsoe, K.; Gloriam, D. E.; Kaae, B. H.; Jimenez, H. N.; Uberti, M. A.; Topiol, S.; Clausen, Rasmus Prætorius; Madsen, U.; Nielsen, S. M.; Mathiesen, J. M.; Brauner-Osborne, H.

    In: Current Neuropharmacology, Vol. 9, 09.2011, p. 43-43.

    Research output: Contribution to journalConference abstract in journalResearch

  13. Published

    Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor. / Gloriam, David E.; Wellendorph, Petrine; Johansen, Lars Dan; Thomsen, Alex Rojas Bie; Phonekeo, Karina; Pedersen, Daniel Sejer; Bräuner-Osborne, Hans.

    In: Chemistry & Biology, Vol. 18, No. 11, 23.11.2011, p. 1489-1498.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Chemogenomics of allosteric binding sites in GPCRs. / Gloriam, David E.

    In: Drug Discovery Today: Technologies, Vol. 10, No. 2, 2013, p. e307-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Comprehensive comparisons of the current human, mouse, and rat RefSeq, Ensembl, EST, and FANTOM3 datasets : identification of new human genes with specific tissue expression profile. / Nordström, Karl J V; Mirza, Majd A I; Larsson, Thomas P; Gloriam, David E.; Fredriksson, Robert; Schiöth, Helgi B.

    In: Biochemical and Biophysical Research Communications, Vol. 348, No. 3, 29.09.2006, p. 1063-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. / Bjarnadóttir, Thóra K; Gloriam, David E.; Hellstrand, Sofia H; Kristiansson, Helena; Fredriksson, Robert; Schiöth, Helgi B.

    In: Genomics, Vol. 88, No. 3, 09.2006, p. 263-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. / Ísberg, Vignir; Andersen, Kirsten Bayer; Bisig, Christoph; Dietz, Gunnar Ph; Bräuner-Osborne, Hans; Gloriam, David Erik.

    In: Journal of Chemical Information and Modeling, Vol. 54, No. 6, 14.05.2014, p. 1553-1557.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Correction : Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-HT2 receptors (PLoS ONE). / Isberg, Vignir; Paine, James; Leth-Petersen, Sebastian; Kristensen, Jesper L.; Gloriam, David E.

    In: PLOS ONE, Vol. 9, No. 1, 17.01.2014.

    Research output: Contribution to journalComment/debateResearchpeer-review

  19. Published

    Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. / Babbitt, Patricia C.; Bagos, Pantelis G.; Bairoch, Amos; Bateman, Alex; Chatonnet, Arnaud; Chen, Mark Jinan; Craik, David J.; Finn, Robert D.; Gloriam, David; Haft, Daniel H.; Henrissat, Bernard; Holliday, Gemma L.; Isberg, Vignir; Kaas, Quentin; Landsman, David; Lenfant, Nicolas; Manning, Gerard; Nagano, Nozomi; Srinivasan, Narayanaswamy; O’Donovan, Claire; Pruitt, Kim D.; Sowdhamini, Ramanathan; Rawlings, Neil D.; Saier, Milton H.; Sharman, Joanna L.; Spedding, Michael; Tsirigos, Konstantinos D.; Vastermark, Ake; Vriend, Gerrit.

    In: Database, Vol. 2015, 18.05.2015, p. 1-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Critical evaluation of the FANTOM3 non-coding RNA transcripts. / Nordström, Karl J V; Mirza, Majd A I; Almén, Markus Sällman; Gloriam, David Erik Immanuel; Fredriksson, Robert; Schiöth, Helgi B.

    In: Genomics, Vol. 94, No. 3, 2009, p. 169-176.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design. / Gloriam, David Erik Immanuel; Foord, Steven M; Blaney, Frank E; Garland, Stephen L.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 14, 2009, p. 4429-4442.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues : novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. / Jensen, Anders A; Plath, Niels; Pedersen, Martin H. F.; Isberg, Vignir; Krall, Jacob; Wellendorph, Petrine; Stensbøl, Tine B.; Gloriam, David E.; Krogsgaard-Larsen, Povl; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 14.02.2013, p. 1211-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. / Di Giglio, Maria Giulia; Muttenthaler, Markus; Harpsøe, Kasper; Liutkeviciute, Zita; Keov, Peter; Eder, Thomas; Rattei, Thomas; Arrowsmith, Sarah; Wray, Susan; Marek, Ales; Elbert, Tomas; Alewood, Paul F; Gloriam, David E; Gruber, Christian W.

    In: Scientific Reports, Vol. 7, 41002, 01.02.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites. / Krall, Jacob; Bavo, Francesco; Falk-Petersen, Christina B; Jensen, Claus Hatt; Nielsen, Julie Olsson; Tian, Yongsong; Anglani, Valeria; Kongstad, Kenneth Thermann; Piilgaard, Louise; Nielsen, Birgitte; Gloriam, David E; Kehler, Jan; Jensen, Anders A.; Harpsøe, Kasper; Wellendorph, Petrine; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 62, No. 5, 14.03.2019, p. 2798-2813.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Editorial overview : New technologies: GPCR drug design and function-exploiting the current (of) structures. / Tautermann, Christofer S; Gloriam, David E.

    In: Current Opinion in Pharmacology, Vol. 30, 02.08.2016, p. 7-10.

    Research output: Contribution to journalComment/debateResearch

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