Christinna Vangsgaard Jørgensen

Christinna Vangsgaard Jørgensen

Postdoc

EDUCATION

2014-            Ph.D. student (start 31.12.2014) at Department of Drug Design and Pharmacology, Copenhagen University, Denmark. Project entitled ’The role of the GPRC6A receptor in mediating osteocalcin reversal of glucocorticoid-induced dysmetabolism’. Supervisors: Hans Bräuner-Osborne, Markus J. Seibel, Stine Jørgensen and Hong Zhou, Department of Drug Design and Pharmacology, Denmark and ANZAC Research Institute, Australia.

 

2010-2012    Master of Science in Molecular Biomedicine, University of Copenhagen, Denmark. Master’s thesis entitled ‘Regulation of 5-HT2A, mGluR2 and CRF-R1 in primary cortical neurons and in Tph2 loss-of-function mice’. Supervisors: Gitte M. Knudsen and Jens D. Mikkelsen, NRU, Rigshospitalet, Copenhagen University Hospital, Denmark.

 

2007-2010    Bachelor of Science in Molecular Biomedicine, University of Copenhagen, Denmark. Bachelor’s thesis entitled ‘Development of a competitive immunoassay based on the monoclonal autoantibody IC2 in a serological testing of type I diabetes’. Supervisor: Carl-Henrik Brogren, Biomedical institute, University of Copenhagen, Denmark.

 

 

WORK EXPERIENCE

2017             Maternity leave.

2016             Stay abroad at ANZAC Research Institute, Sydney, Australia (2 months)

2014             Maternity leave.

2012-2013    Research Assistant at NRU, Rigshospitalet, Copenhagen University Hospital, Denmark.

2012-2013    Stationed abroad Research Assistant in Prof. John P. Bruno’s laboratory at the Psychology department, Ohio State University, USA (13 months).

2009-2012    Coorganizer of Dansk Psykiatrisk Selskab’s annual Summer School for medical students.

2007-2010    Student Assistant at Psychiatric Center København, Rigshospitalet, Copenhagen University Hospital, Denmark (part time).

  

CERTIFICATIONS

2011    Laboratory Animal Science (FELASA Cat. C), University of Copenhagen.

 

 

LABORATORY SKILLS

-Knowledge in basal neurobiology research and behavioral neuroscience.

-Experience with animal models and animal experiments

-Techniques: culture and maintain primary neuronal cultures, primary adipocytes and cell lines, qPCR, Western blotting, ELISA, autoradiography, stereotaxic surgery, attentional set-shifting testing, operant boxes, Corning Epic, IPone and Seahorse XF96.

 

 

PUBLICATIONS

Jørgensen CV, Klein AB, El-Sayed M, Knudsen GM and Mikkelsen JD (2013). Metabotropic glutamate receptor 2 and corticotrophin-releasing factor receptor-1 gene expression is differently regulated by BDNF in rat primary cortical neurons. Synapse, 67(11):794-800.

 

Jørgensen CV, Jacobsen JP, Klein AB, Caron MG, Knudsen GM and Mikkelsen JD (2013). Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase decrease-of-function mice. Neuroscience Lett., 555:118-22.

 

Bortz D, Jørgensen CV, Mikkelsen JD, Bruno JP (2014). Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of glutamate release in adulthood. Neuropharmacology.

 

Pershing ML, Bortz D, Pocivavsek A, Fredericks PJ, Leuner B, Jørgensen CV, Schwarcz R, Bruno JP (2015). Prenatal kynurenic acid elevation alters cortical development and prefrontal glutamate release, corresponding to cognitive inflexibility in adults.

 

Jørgensen S, Have CT, Underwood CR, Johansen LD, Wellendorph P, Gjesing AP, Jørgensen CV, Quan S, Rui G, Inoue A, Linneberg A, Grarup N, Jun W, Pedersen O, Hansen T, Bräuner-Osborne H (2017). Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function. J Biol Chem, 292(4):1524-1534.

 

Clemmensen C*, Jørgensen CV*, Smajilovic S, Bräuner-Osborne H (2016). Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor. Diabetes, obesity and metabolism. 19(4):599-603.

 

 

ABSTRACTS

Vunck SA, Pershing ML, Bortz D, Jørgensen CV, Schwarcz R, Bruno JP. Evidence for both an alpha7 nicotinic and glycine B receptor mediation of working memory in the rat. American College of Neuropsychopharmacology, Hollywood, FL, Dec 2013.

 

Bruno JP, VunckSA, PershingML, PocivavsekA, BortzA, Jørgensen CV, FredericksPJ, Leuner B, Schwarcz R. Elevations of brain kynurenic acid in prenatal rats result in long-lasting impairments in cortical development and cognitive flexibility: Implications for schizophrenia. American College of Neuropsychopharmacology, Hollywood, FL, Dec 2013.

 

Overgaard A, Lie MEK, Jørgensen CV, Mikkelsen JD, Knudsen GM, Frokjaer VG.SERT binding is increased by a GnRH receptor agonist in female rats. European College of Neuropsychopharmacology, Barcelona, Spain, Oct 2013.

 

Pershing ML, Bortz D, Pocivavsek A, Fredericks PJ, Leuner B, Jørgensen CV, Schwarcz R, Bruno JP. Prenatal kynurenic acid elevation alters cortical development and prefrontal glutamate release, corresponding to cognitive inflexibility in adults. Program No. 255.11. 2013 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2013. Online.

 

Jørgensen CV, Jacobsen JP, Klein AB, Lehmann C, Caron MG, Knudsen GM and Mikkelsen JD. Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase loss-of-function mice. Program No. 430.06. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.

 

Jørgensen CV, Klein AB, El-Sayed M, Knudsen GM and Mikkelsen JD. Brain-derived neurotrophic factor changes metabotropic glutamate receptor 2 and corticotrophin-releasing factor receptor 1 gene expression in primary cortical neurons. Program No. 738.14. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.

 

Jørgensen CV, El-Sayed M, Hofman-Bang J, Mikkelsen JD. Brain-derived neurotrophic factor, but not N-acetylserotonin, strongly induces gene expression in rat primary cortical neurons. Program No. 39.09. 2011 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2011. Online.

 

 

PRESENTATIONS

2016              DRA Summer School.

2013              Oral presentation at the annual NRU symposium.

2013              Oral presentation at the annual COGNITO meeting in Copenhagen.

2012              Society for Neuroscience annual meeting in New Orleans, LO.

2011              Neurodag, University of Copenhagen.

2011              Society for Neuroscience annual meeting in Washington D.C.

2011              Oral presentation at the annual NRU symposium.

ID: 129435970