Carsten Geisler

Carsten Geisler

Head of Department, Professor

Primary fields of research

http://isim.ku.dk/research/t_cell_biology/

 

Current research

http://isim.ku.dk/research/t_cell_biology/

Selected publications

  1. Published

    Vitamin D controls T cell antigen receptor signaling and activation of human T cells

    von Essen, M. R., Kongsbak-Wismann, M., Schjerling, P., Ølgaard, K., Ødum, N. & Geisler, C., 2010, In : Nature Immunology. 11, 4, p. 344-349 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    TCR down-regulation controls T cell homeostasis

    Boding, L., Bonefeld, C. M., Nielsen, B. L., Lauritsen, J. P. H., von Essen, M. R., Hansen, A. K., Larsen, J. M., Nielsen, M. M., Odum, N. & Geisler, C., 2009, In : Journal of Immunology. 183, 8, p. 4994-5005 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Protein kinase C (PKC) alpha and PKC theta are the major PKC isotypes involved in TCR down-regulation

    von Essen, M., Nielsen, M. W., Bonefeld, C. M., Boding, L., Larsen, J. M., Leitges, M., Baier, G., Odum, N. & Geisler, C., 2006, In : Journal of Immunology. 176, 12, p. 7502-10 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Constitutive and ligand-induced TCR degradation

    von Essen, M., Bonefeld, C. M., Siersma, V., Rasmussen, A. B., Lauritsen, J. P. H., Nielsen, B. L. & Geisler, C., 2004, In : Journal of Immunology. 173, 1, p. 384-93 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    TCR trafficking in resting and stimulated T cells

    Geisler, C., 2004, In : Critical Reviews in Immunology. 24, 1, p. 67-86 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    TCR comodulation of nonengaged TCR takes place by a protein kinase C and CD3 gamma di-leucine-based motif-dependent mechanism

    Bonefeld, C. M., Rasmussen, B. A., Lauritsen, J. P., von Essen, M., Odum, N., Andersen, P. S. & Geisler, C., 2003, In : Journal of Immunology. 171, 6, p. 3003-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Endo- and exocytic rate constants for spontaneous and protein kinase C-activated T cell receptor cycling

    Menné, C., Møller Sørensen, T., Siersma, V., von Essen, M., Ødum, N. & Geisler, C., 2002, In : European Journal of Immunology. 32, 3, p. 616-26 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Ligand-induced TCR down-regulation is not dependent on constitutive TCR cycling

    Dietrich, J., Menné, C., Lauritsen, J. P. H., von Essen, M., Rasmussen, B. A., Ødum, N. & Geisler, C., 2002, In : Journal of Immunology. 168, 11, p. 5434-40 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The CD3 gamma leucine-based receptor-sorting motif is required for efficient ligand-mediated TCR down-regulation

    von Essen, M., Menné, C., Nielsen, B. L., Lauritsen, J. P. H., Dietrich, J., Andersen, P. S., Karjalainen, K., Ødum, N. & Geisler, C., 2002, In : Journal of Immunology. 168, 9, p. 4519-23 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Leucine-based receptor sorting motifs are dependent on the spacing relative to the plasma membrane

    Geisler, C., Dietrich, J., Nielsen, B. L., Kastrup, J., Lauritsen, J. P. H., Odum, N. & Christensen, M. D., 1998, In : Journal of Biological Chemistry. 273, 33, p. 21316-23 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The phosphorylation state of CD3gamma influences T cell responsiveness and controls T cell receptor cycling

    Dietrich, J., Bäckström, T., Lauritsen, J. P., Kastrup, J., Christensen, M. D., von Bülow, F., Palmer, E. & Geisler, C., 1998, In : Journal of Biological Chemistry. 273, 37, p. 24232-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Two distinct pathways exist for down-regulation of the TCR

    Lauritsen, J. P., Christensen, M. D., Dietrich, J., Kastrup, J., Odum, N. & Geisler, C., 1998, In : Journal of Immunology. 161, 1, p. 260-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Regulation and function of the CD3¿ DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro

    Dietrich, J., Kastrup, J., Nielsen, B. L., Odum, N. & Geisler, C., 1997, In : Journal of Cell Biology. 138, 2, p. 271-81 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Molecular characterization of the di-leucine-based internalization motif of the T cell receptor

    Dietrich, J., Hou, X., Wegener, A. M., Pedersen, L. O., Odum, N. & Geisler, C., 1996, In : Journal of Biological Chemistry. 271, 19, p. 11441-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Role of CD3 gamma in T cell receptor assembly

    Dietrich, J., Neisig, A., Hou, X., Wegener, A. M., Gajhede, M. & Geisler, C., 1996, In : Journal of Cell Biology. 132, 3, p. 299-310 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Distinct domains of the CD3-gamma chain are involved in surface expression and function of the T cell antigen receptor

    Wegener, A. M., Hou, X., Dietrich, J. & Geisler, C., 1995, In : Journal of Biological Chemistry. 270, 9, p. 4675-80 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor

    Dietrich, J., Hou, X., Wegener, A. M. & Geisler, C., 1994, In : EMBO Journal. 13, 9, p. 2156-66 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Failure to synthesize the CD3-gamma chain. Consequences for T cell antigen receptor assembly, processing, and expression

    Geisler, C., 1992, In : Journal of Immunology. 148, 8, p. 2437-45 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 10043