The role of DNA base excision repair in brain homeostasis and disease
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The role of DNA base excision repair in brain homeostasis and disease. / Akbari, Mansour; Morevati, Marya; Croteau, Deborah; Bohr, Vilhelm A.
In: DNA Repair, Vol. 32, 08.2015, p. 172-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The role of DNA base excision repair in brain homeostasis and disease
AU - Akbari, Mansour
AU - Morevati, Marya
AU - Croteau, Deborah
AU - Bohr, Vilhelm A
N1 - Published by Elsevier B.V.
PY - 2015/8
Y1 - 2015/8
N2 - Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.
AB - Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.
U2 - 10.1016/j.dnarep.2015.04.029
DO - 10.1016/j.dnarep.2015.04.029
M3 - Journal article
C2 - 26002197
VL - 32
SP - 172
EP - 179
JO - DNA Repair
JF - DNA Repair
SN - 1568-7864
ER -
ID: 138764331