The role of DNA base excision repair in brain homeostasis and disease

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The role of DNA base excision repair in brain homeostasis and disease. / Akbari, Mansour; Morevati, Marya; Croteau, Deborah; Bohr, Vilhelm A.

In: DNA Repair, Vol. 32, 08.2015, p. 172-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Akbari, M, Morevati, M, Croteau, D & Bohr, VA 2015, 'The role of DNA base excision repair in brain homeostasis and disease', DNA Repair, vol. 32, pp. 172-9. https://doi.org/10.1016/j.dnarep.2015.04.029

APA

Akbari, M., Morevati, M., Croteau, D., & Bohr, V. A. (2015). The role of DNA base excision repair in brain homeostasis and disease. DNA Repair, 32, 172-9. https://doi.org/10.1016/j.dnarep.2015.04.029

Vancouver

Akbari M, Morevati M, Croteau D, Bohr VA. The role of DNA base excision repair in brain homeostasis and disease. DNA Repair. 2015 Aug;32:172-9. https://doi.org/10.1016/j.dnarep.2015.04.029

Author

Akbari, Mansour ; Morevati, Marya ; Croteau, Deborah ; Bohr, Vilhelm A. / The role of DNA base excision repair in brain homeostasis and disease. In: DNA Repair. 2015 ; Vol. 32. pp. 172-9.

Bibtex

@article{59657c301f034f82801d0dc69ccd6d54,
title = "The role of DNA base excision repair in brain homeostasis and disease",
abstract = "Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.",
author = "Mansour Akbari and Marya Morevati and Deborah Croteau and Bohr, {Vilhelm A}",
note = "Published by Elsevier B.V.",
year = "2015",
month = "8",
doi = "10.1016/j.dnarep.2015.04.029",
language = "English",
volume = "32",
pages = "172--9",
journal = "D N A Repair",
issn = "1568-7864",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The role of DNA base excision repair in brain homeostasis and disease

AU - Akbari, Mansour

AU - Morevati, Marya

AU - Croteau, Deborah

AU - Bohr, Vilhelm A

N1 - Published by Elsevier B.V.

PY - 2015/8

Y1 - 2015/8

N2 - Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.

AB - Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.

U2 - 10.1016/j.dnarep.2015.04.029

DO - 10.1016/j.dnarep.2015.04.029

M3 - Journal article

VL - 32

SP - 172

EP - 179

JO - D N A Repair

JF - D N A Repair

SN - 1568-7864

ER -

ID: 138764331