The effect of intravenous omeprazole on the gastric and duodenal potential difference and pH in healthy subjects

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E Rubinstein, L Højgaard

The effect of intravenous omeprazole (40 and 80 mg) on the gastric and duodenal potential difference (PD) and pH was investigated in 9 healthy volunteers. Gastric PD and pH increased significantly (p < 0.05) following omeprazole, and the increases were equal following the two doses. No changes were found in duodenal PD or pH. It has been claimed that gastric PD changes following acid secretion inhibition with cimetidine and glucagon might be due to changes in the parietal cell surface area. Omeprazole causes no changes in the parietal cell structure, and the changes in gastric PD following omeprazole might therefore be ascribed to changes in mucosal electrophysiologic transport or resistance.

Original languageEnglish
JournalDigestion
Volume54
Issue number1
Pages (from-to)15-8
Number of pages4
ISSN0012-2823
Publication statusPublished - 1993

    Research areas

  • Action Potentials, Adult, Biological Transport, Duodenum, Gastric Mucosa, Humans, Hydrogen-Ion Concentration, Injections, Intravenous, Omeprazole, Parietal Cells, Gastric, Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial

ID: 165884732