The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin.

Research output: Contribution to journal › Journal article › Research › peer-review

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The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin. / Couchman, J R; Rees, D A.

In: Journal of Cell Science, Vol. 39, 1979, p. 149-65.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Couchman, JR & Rees, DA 1979, 'The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin.', Journal of Cell Science, vol. 39, pp. 149-65.

APA

Couchman, J. R., & Rees, D. A. (1979). The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin. Journal of Cell Science, 39, 149-65.

Vancouver

Couchman JR, Rees DA. The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin. Journal of Cell Science. 1979;39:149-65.

Author

Couchman, J R ; Rees, D A. / The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin. In: Journal of Cell Science. 1979 ; Vol. 39. pp. 149-65.

Bibtex

@article{60811d60599011dd8d9f000ea68e967b,
title = "The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin.",
abstract = "Fibroblasts migrating from heart explants of chick embryos at first have a high rate of locomotion but lack focal contacts or adhesions and also lack substantial actin-containing bundles. A meshwork of 7-nm filaments is present particularly in submembranous regions and is proposed to be directed towards efficient locomotion whilst maintaining a high degree of spreading. Also during the first 48 h there is little production of extracellular fibronectin and the growth rate is low. Later, these fibroblasts develop focal contacts and focal adhesions together with actomyosin bundles, with a parallel increase in fibronectin expression. We propose that progressive immobilization by the development of focal adhesions and actomyosin structures occurs to set these cells up for growth.",
author = "Couchman, {J R} and Rees, {D A}",
note = "Keywords: Actomyosin; Animals; Cell Adhesion; Cell Cycle; Cell Division; Cell Membrane; Cell Movement; Chick Embryo; Cytoskeleton; Fibroblasts; Fibronectins; Myocardium",
year = "1979",
language = "English",
volume = "39",
pages = "149--65",
journal = "Journal of Cell Science",
issn = "0021-9533",
publisher = "The/Company of Biologists Ltd.",

}

RIS

TY - JOUR

T1 - The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin.

AU - Couchman, J R

AU - Rees, D A

N1 - Keywords: Actomyosin; Animals; Cell Adhesion; Cell Cycle; Cell Division; Cell Membrane; Cell Movement; Chick Embryo; Cytoskeleton; Fibroblasts; Fibronectins; Myocardium

PY - 1979

Y1 - 1979

N2 - Fibroblasts migrating from heart explants of chick embryos at first have a high rate of locomotion but lack focal contacts or adhesions and also lack substantial actin-containing bundles. A meshwork of 7-nm filaments is present particularly in submembranous regions and is proposed to be directed towards efficient locomotion whilst maintaining a high degree of spreading. Also during the first 48 h there is little production of extracellular fibronectin and the growth rate is low. Later, these fibroblasts develop focal contacts and focal adhesions together with actomyosin bundles, with a parallel increase in fibronectin expression. We propose that progressive immobilization by the development of focal adhesions and actomyosin structures occurs to set these cells up for growth.

AB - Fibroblasts migrating from heart explants of chick embryos at first have a high rate of locomotion but lack focal contacts or adhesions and also lack substantial actin-containing bundles. A meshwork of 7-nm filaments is present particularly in submembranous regions and is proposed to be directed towards efficient locomotion whilst maintaining a high degree of spreading. Also during the first 48 h there is little production of extracellular fibronectin and the growth rate is low. Later, these fibroblasts develop focal contacts and focal adhesions together with actomyosin bundles, with a parallel increase in fibronectin expression. We propose that progressive immobilization by the development of focal adhesions and actomyosin structures occurs to set these cells up for growth.

M3 - Journal article

C2 - 575139

VL - 39

SP - 149

EP - 165

JO - Journal of Cell Science

JF - Journal of Cell Science

SN - 0021-9533

ER -

ID: 5167990