Syndecans and cell adhesion.

Research output: Contribution to journalJournal articleResearchpeer-review

J R Couchman, L Chen, A Woods

Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors, development, and tumorigenesis. This review will describe this family of proteoglycans in terms of their structures and functions and their signaling in conjunction with integrins, and indicate areas for future research.
Original languageEnglish
Book seriesInternational Review of Cytology
Volume207
Pages (from-to)113-50
Number of pages37
ISSN0074-7696
Publication statusPublished - 2001

Bibliographical note

Keywords: Amino Acid Sequence; Animals; Cell Adhesion; Glycosaminoglycans; Humans; Membrane Glycoproteins; Models, Molecular; Molecular Sequence Data; Phylogeny; Protein Structure, Tertiary; Proteoglycans; Sequence Alignment; Signal Transduction; Syndecans

ID: 5163209