Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma

Research output: Contribution to journalJournal articleResearchpeer-review

Maria E Lendorf, Tina Manon-Jensen, Pauliina Kronqvist, Hinke A B Multhaupt, John R Couchman

Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation. Their expression can also serve as prognostic markers. In breast carcinomas, syndecan-1 overexpression correlates with poor prognosis and aggressive phenotype. Syndecan-4 is expressed in most breast carcinoma cell lines, but its role in malignancy is unclear. A possible relationship between syndecan-1 and syndecan-4 expression and established prognostic factors in breast carcinomas was examined. Duplicate samples of 114 benign and malignant breast disease cases were stained for the two syndecans. Clinicopathological information was available for all cases. Syndecan-1 was detected in 72.8% of cases, with significant association between its expression and histological tumor type (p
Original languageEnglish
JournalJournal of Histochemistry and Cytochemistry
Volume59
Issue number6
Pages (from-to)615-29
Number of pages15
ISSN0022-1554
DOIs
Publication statusPublished - 1 Jun 2011

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Breast Neoplasms, Case-Control Studies, Female, Fluorescent Antibody Technique, Humans, Immunohistochemistry, Middle Aged, Syndecan-1, Syndecan-4, Tumor Markers, Biological, Young Adult

ID: 33789003