Stage-specific remodeling of the mammary gland basement membrane during lactogenic development

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Stage-specific remodeling of the mammary gland basement membrane during lactogenic development. / Beck, James C.; Lekutis, Christine; Couchman, John; Parry, Gordon.

In: Biochemical and Biophysical Research Communications, Vol. 190, No. 2, 01.01.1993, p. 616-623.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Beck, JC, Lekutis, C, Couchman, J & Parry, G 1993, 'Stage-specific remodeling of the mammary gland basement membrane during lactogenic development', Biochemical and Biophysical Research Communications, vol. 190, no. 2, pp. 616-623. https://doi.org/10.1006/bbrc.1993.1093

APA

Beck, J. C., Lekutis, C., Couchman, J., & Parry, G. (1993). Stage-specific remodeling of the mammary gland basement membrane during lactogenic development. Biochemical and Biophysical Research Communications, 190(2), 616-623. https://doi.org/10.1006/bbrc.1993.1093

Vancouver

Beck JC, Lekutis C, Couchman J, Parry G. Stage-specific remodeling of the mammary gland basement membrane during lactogenic development. Biochemical and Biophysical Research Communications. 1993 Jan 1;190(2):616-623. https://doi.org/10.1006/bbrc.1993.1093

Author

Beck, James C. ; Lekutis, Christine ; Couchman, John ; Parry, Gordon. / Stage-specific remodeling of the mammary gland basement membrane during lactogenic development. In: Biochemical and Biophysical Research Communications. 1993 ; Vol. 190, No. 2. pp. 616-623.

Bibtex

@article{cb40444eb66a42b0a8ef9a9cf97f4ed9,
title = "Stage-specific remodeling of the mammary gland basement membrane during lactogenic development",
abstract = "Several in vitro studies have highlighted the importance of extracellular matrix proteoglycans as regulators of mammary epithelial cell differentiation. In this study monospecific antibodies to heparan (HS) and chondroitin/dermatan sulfate (CS/DS) proteoglycans were used to determine their possible significance in vivo. Immunohistochemical studies of proteoglycan distribution in virgin, pregnant, and lactating tissue demonstrated that heparan sulfate proteoglycan was found in the epithelial cell basement membrane at all stages of development. This was also true for CS/DS proteoglycans, but the relative proportions of CS and DS were strikingly modulated during lactogenesis. Notably DS glycosaminoglycans were the dominant components of the basement membrane in lactating tissue but CS glycosaminoglycans were the major proteoglycans of pregnant tissue. The possible significance of these results for gene expression in the gland is discussed.",
author = "Beck, {James C.} and Christine Lekutis and John Couchman and Gordon Parry",
year = "1993",
month = jan,
day = "1",
doi = "10.1006/bbrc.1993.1093",
language = "English",
volume = "190",
pages = "616--623",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Stage-specific remodeling of the mammary gland basement membrane during lactogenic development

AU - Beck, James C.

AU - Lekutis, Christine

AU - Couchman, John

AU - Parry, Gordon

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Several in vitro studies have highlighted the importance of extracellular matrix proteoglycans as regulators of mammary epithelial cell differentiation. In this study monospecific antibodies to heparan (HS) and chondroitin/dermatan sulfate (CS/DS) proteoglycans were used to determine their possible significance in vivo. Immunohistochemical studies of proteoglycan distribution in virgin, pregnant, and lactating tissue demonstrated that heparan sulfate proteoglycan was found in the epithelial cell basement membrane at all stages of development. This was also true for CS/DS proteoglycans, but the relative proportions of CS and DS were strikingly modulated during lactogenesis. Notably DS glycosaminoglycans were the dominant components of the basement membrane in lactating tissue but CS glycosaminoglycans were the major proteoglycans of pregnant tissue. The possible significance of these results for gene expression in the gland is discussed.

AB - Several in vitro studies have highlighted the importance of extracellular matrix proteoglycans as regulators of mammary epithelial cell differentiation. In this study monospecific antibodies to heparan (HS) and chondroitin/dermatan sulfate (CS/DS) proteoglycans were used to determine their possible significance in vivo. Immunohistochemical studies of proteoglycan distribution in virgin, pregnant, and lactating tissue demonstrated that heparan sulfate proteoglycan was found in the epithelial cell basement membrane at all stages of development. This was also true for CS/DS proteoglycans, but the relative proportions of CS and DS were strikingly modulated during lactogenesis. Notably DS glycosaminoglycans were the dominant components of the basement membrane in lactating tissue but CS glycosaminoglycans were the major proteoglycans of pregnant tissue. The possible significance of these results for gene expression in the gland is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0027198065&partnerID=8YFLogxK

U2 - 10.1006/bbrc.1993.1093

DO - 10.1006/bbrc.1993.1093

M3 - Journal article

AN - SCOPUS:0027198065

VL - 190

SP - 616

EP - 623

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -

ID: 225719486