Proteoglycans in health and disease: the multiple roles of syndecan shedding
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Proteoglycans in health and disease: the multiple roles of syndecan shedding. / Manon-Jensen, Tina; Itoh, Yoshifumi; Couchman, John R.
In: FEBS Journal, Vol. 277, No. 19, 2010, p. 3876-89.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Proteoglycans in health and disease: the multiple roles of syndecan shedding
AU - Manon-Jensen, Tina
AU - Itoh, Yoshifumi
AU - Couchman, John R
N1 - © 2010 The Authors Journal compilation © 2010 FEBS.
PY - 2010
Y1 - 2010
N2 - Proteolytic processes in the extracellular matrix are a major influence on cell adhesion, migration, survival, differentiation and proliferation. The syndecan cell-surface proteoglycans are important mediators of cell spreading on extracellular matrix and respond to growth factors and other biologically active polypeptides. The ectodomain of each syndecan is constitutively shed from many cultured cells, but is accelerated in response to wound healing and diverse pathophysiological events. Ectodomain shedding is an important regulatory mechanism, because it rapidly changes surface receptor dynamics and generates soluble ectodomains that can function as paracrine or autocrine effectors, or competitive inhibitors. It is known that the family of syndecans can be shed by a variety of matrix proteinase, including many metzincins. Shedding is particularly active in proliferating and invasive cells, such as cancer cells, where cell-surface components are continually released. Here, recent research into the shedding of syndecans and its physiological relevance are assessed.
AB - Proteolytic processes in the extracellular matrix are a major influence on cell adhesion, migration, survival, differentiation and proliferation. The syndecan cell-surface proteoglycans are important mediators of cell spreading on extracellular matrix and respond to growth factors and other biologically active polypeptides. The ectodomain of each syndecan is constitutively shed from many cultured cells, but is accelerated in response to wound healing and diverse pathophysiological events. Ectodomain shedding is an important regulatory mechanism, because it rapidly changes surface receptor dynamics and generates soluble ectodomains that can function as paracrine or autocrine effectors, or competitive inhibitors. It is known that the family of syndecans can be shed by a variety of matrix proteinase, including many metzincins. Shedding is particularly active in proliferating and invasive cells, such as cancer cells, where cell-surface components are continually released. Here, recent research into the shedding of syndecans and its physiological relevance are assessed.
U2 - 10.1111/j.1742-4658.2010.07798.x
DO - 10.1111/j.1742-4658.2010.07798.x
M3 - Journal article
C2 - 20840585
VL - 277
SP - 3876
EP - 3889
JO - F E B S Journal
JF - F E B S Journal
SN - 1742-464X
IS - 19
ER -
ID: 22268386