Plasma YKL-40 in Inuit and Danes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Plasma YKL-40 in Inuit and Danes. / Nøjgaard, Camilla; Johansen, Julia S; Bjerregaard, Peter; Bojesen, Stig E; Becker, Ulrik.

In: Alcohol and Alcoholism, Vol. 50, No. 1, 01.01.2015, p. 11-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nøjgaard, C, Johansen, JS, Bjerregaard, P, Bojesen, SE & Becker, U 2015, 'Plasma YKL-40 in Inuit and Danes', Alcohol and Alcoholism, vol. 50, no. 1, pp. 11-7. https://doi.org/10.1093/alcalc/agu072

APA

Nøjgaard, C., Johansen, J. S., Bjerregaard, P., Bojesen, S. E., & Becker, U. (2015). Plasma YKL-40 in Inuit and Danes. Alcohol and Alcoholism, 50(1), 11-7. https://doi.org/10.1093/alcalc/agu072

Vancouver

Nøjgaard C, Johansen JS, Bjerregaard P, Bojesen SE, Becker U. Plasma YKL-40 in Inuit and Danes. Alcohol and Alcoholism. 2015 Jan 1;50(1):11-7. https://doi.org/10.1093/alcalc/agu072

Author

Nøjgaard, Camilla ; Johansen, Julia S ; Bjerregaard, Peter ; Bojesen, Stig E ; Becker, Ulrik. / Plasma YKL-40 in Inuit and Danes. In: Alcohol and Alcoholism. 2015 ; Vol. 50, No. 1. pp. 11-7.

Bibtex

@article{a8695e70b07c4531804d302175e5c9f7,

title = "Plasma YKL-40 in Inuit and Danes",

abstract = "AIMS: The aim of the present study was to investigate whether there are differences in plasma levels of YKL-40 between Inuit in Greenland and in Denmark and in Danes, as well as to study the relationship between alcohol intake, plasma YKL-40 and other factors in Inuit.METHODS: Plasma YKL-40 levels were measured on 1645 people from The Greenland Population Study (a cross-sectional population study of Inuit from Denmark and West Greenland) and were compared with the plasma YKL-40 levels of 8899 people from The Copenhagen City Heart Study (a population-based, prospective study of the Danish general population).RESULTS: The plasma concentrations of YKL-40 were significantly (P = 0.001) lower in Inuit living in Greenland (median 46 µg/l, range 10-2164, n = 1164) compared with the plasma YKL-40 levels of Inuit living in Denmark (median 63 µg/l, range 20-2827, n = 481) and of Danes living in Denmark (median 55 µg/l, range 10-2909, n = 8899). In Inuit, increased alcohol intake was significantly associated with increased plasma YKL-40 levels (P < 0.001), and high plasma YKL-40 levels were associated with high values of alkaline phosphatase and low values of albumin. Smoking, gender and bilirubin were not associated with the plasma YKL-40 level. High levels of YKL-40 and alcohol were associated with where people lived.CONCLUSION: The plasma concentrations of YKL-40 are significantly lower in Inuit living in Greenland than Inuit and Danes living in Denmark. A number of factors, including different alcohol intake patterns, nutrition and genes may play a role in these findings.",

keywords = "Adipokines, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Alcohol Drinking, Cross-Sectional Studies, Denmark, European Continental Ancestry Group, Female, Greenland, Humans, Inuits, Lectins, Male, Middle Aged, Sex Factors, Young Adult",

author = "Camilla N{\o}jgaard and Johansen, {Julia S} and Peter Bjerregaard and Bojesen, {Stig E} and Ulrik Becker",

year = "2015",

month = jan,

day = "1",

doi = "10.1093/alcalc/agu072",

language = "English",

volume = "50",

pages = "11--7",

journal = "Alcohol and Alcoholism",

issn = "0735-0414",

publisher = "Oxford University Press",

number = "1",

}

RIS

TY - JOUR

T1 - Plasma YKL-40 in Inuit and Danes

AU - Nøjgaard, Camilla

AU - Johansen, Julia S

AU - Bjerregaard, Peter

AU - Bojesen, Stig E

AU - Becker, Ulrik

PY - 2015/1/1

Y1 - 2015/1/1

N2 - AIMS: The aim of the present study was to investigate whether there are differences in plasma levels of YKL-40 between Inuit in Greenland and in Denmark and in Danes, as well as to study the relationship between alcohol intake, plasma YKL-40 and other factors in Inuit.METHODS: Plasma YKL-40 levels were measured on 1645 people from The Greenland Population Study (a cross-sectional population study of Inuit from Denmark and West Greenland) and were compared with the plasma YKL-40 levels of 8899 people from The Copenhagen City Heart Study (a population-based, prospective study of the Danish general population).RESULTS: The plasma concentrations of YKL-40 were significantly (P = 0.001) lower in Inuit living in Greenland (median 46 µg/l, range 10-2164, n = 1164) compared with the plasma YKL-40 levels of Inuit living in Denmark (median 63 µg/l, range 20-2827, n = 481) and of Danes living in Denmark (median 55 µg/l, range 10-2909, n = 8899). In Inuit, increased alcohol intake was significantly associated with increased plasma YKL-40 levels (P < 0.001), and high plasma YKL-40 levels were associated with high values of alkaline phosphatase and low values of albumin. Smoking, gender and bilirubin were not associated with the plasma YKL-40 level. High levels of YKL-40 and alcohol were associated with where people lived.CONCLUSION: The plasma concentrations of YKL-40 are significantly lower in Inuit living in Greenland than Inuit and Danes living in Denmark. A number of factors, including different alcohol intake patterns, nutrition and genes may play a role in these findings.

AB - AIMS: The aim of the present study was to investigate whether there are differences in plasma levels of YKL-40 between Inuit in Greenland and in Denmark and in Danes, as well as to study the relationship between alcohol intake, plasma YKL-40 and other factors in Inuit.METHODS: Plasma YKL-40 levels were measured on 1645 people from The Greenland Population Study (a cross-sectional population study of Inuit from Denmark and West Greenland) and were compared with the plasma YKL-40 levels of 8899 people from The Copenhagen City Heart Study (a population-based, prospective study of the Danish general population).RESULTS: The plasma concentrations of YKL-40 were significantly (P = 0.001) lower in Inuit living in Greenland (median 46 µg/l, range 10-2164, n = 1164) compared with the plasma YKL-40 levels of Inuit living in Denmark (median 63 µg/l, range 20-2827, n = 481) and of Danes living in Denmark (median 55 µg/l, range 10-2909, n = 8899). In Inuit, increased alcohol intake was significantly associated with increased plasma YKL-40 levels (P < 0.001), and high plasma YKL-40 levels were associated with high values of alkaline phosphatase and low values of albumin. Smoking, gender and bilirubin were not associated with the plasma YKL-40 level. High levels of YKL-40 and alcohol were associated with where people lived.CONCLUSION: The plasma concentrations of YKL-40 are significantly lower in Inuit living in Greenland than Inuit and Danes living in Denmark. A number of factors, including different alcohol intake patterns, nutrition and genes may play a role in these findings.

KW - Adipokines

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Alcohol Drinking

KW - Cross-Sectional Studies

KW - Denmark

KW - European Continental Ancestry Group

KW - Female

KW - Greenland

KW - Humans

KW - Inuits

KW - Lectins

KW - Male

KW - Middle Aged

KW - Sex Factors

KW - Young Adult

U2 - 10.1093/alcalc/agu072

DO - 10.1093/alcalc/agu072

M3 - Journal article

C2 - 25332349

VL - 50

SP - 11

EP - 17

JO - Alcohol and Alcoholism

JF - Alcohol and Alcoholism

SN - 0735-0414

IS - 1

ER -

ID: 160616391