PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients

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Standard

PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients. / Berthelsen, A K; Holm, S; Loft, A; Klausen, T L; Andersen, F; Højgaard, L.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 32, No. 10, 10.2005, p. 1167-75.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Berthelsen, AK, Holm, S, Loft, A, Klausen, TL, Andersen, F & Højgaard, L 2005, 'PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients', European Journal of Nuclear Medicine and Molecular Imaging, vol. 32, no. 10, pp. 1167-75. https://doi.org/10.1007/s00259-005-1784-1

APA

Berthelsen, A. K., Holm, S., Loft, A., Klausen, T. L., Andersen, F., & Højgaard, L. (2005). PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients. European Journal of Nuclear Medicine and Molecular Imaging, 32(10), 1167-75. https://doi.org/10.1007/s00259-005-1784-1

Vancouver

Berthelsen AK, Holm S, Loft A, Klausen TL, Andersen F, Højgaard L. PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients. European Journal of Nuclear Medicine and Molecular Imaging. 2005 Oct;32(10):1167-75. https://doi.org/10.1007/s00259-005-1784-1

Author

Berthelsen, A K ; Holm, S ; Loft, A ; Klausen, T L ; Andersen, F ; Højgaard, L. / PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients. In: European Journal of Nuclear Medicine and Molecular Imaging. 2005 ; Vol. 32, No. 10. pp. 1167-75.

Bibtex

@article{4442c8cb368d4c49961424ade36bdf16,
title = "PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients",
abstract = "PURPOSE: If the CT scan of a combined PET/CT study is performed as a full diagnostic quality CT scan including intravenous (IV) contrast agent, the quality of the joint PET/CT procedure is improved and a separate diagnostic CT scan can be avoided. CT with IV contrast can be used for PET attenuation correction, but this may result in a bias in the attenuation factors. The clinical significance of this bias has not been established. Our aim was to perform a prospective clinical study where each patient had CT performed with and without IV contrast agent to establish whether PET/CT with IV contrast can be used for PET attenuation without reducing the clinical value of the PET scan.METHODS: A uniform phantom study was used to document that the PET acquisition itself is not significantly influenced by the presence of IV contrast medium. Then, 19 patients referred to PET/CT with IV contrast underwent CT scans without, and then with contrast agent, followed by an 18F-fluorodeoxyglucose whole-body PET scan. The CT examinations were performed with identical parameters on a GE Discovery LS scanner. The PET data were reconstructed with attenuation correction based on the two CT data sets. A global comparison of standard uptake value (SUV) was performed, and SUVs in tumour, in non-tumour tissue and in the subclavian vein were calculated. Clinical evaluation of the number and location of lesions on all PET/CT scans was performed twice, blinded and in a different random order, by two independent nuclear medicine specialists.RESULTS: In all patients, the measured global SUV of PET images based on CT with IV contrast agent was higher than the global activity using non-contrast correction. The overall increase in the mean SUV (for two different conversion tables tested) was 4.5+/-2.3{\%} and 1.6+/-0.5{\%}, respectively. In 11/19 patients, focal uptake was identified corresponding to malignant tumours. Eight out of 11 tumours showed an increased SUVmax (2.9+/-3.1{\%}) on the PET images reconstructed using IV contrast. The clinical evaluation performed by the two specialists comparing contrast and non-contrast CT attenuated PET images showed weighted kappa values of 0.92 (doctor A) and 0.82 (doctor B). No contrast-introduced artefacts were found.CONCLUSION: This study demonstrates that CT scans with IV contrast agent can be used for attenuation correction of the PET data in combined modality PET/CT scanning, without changing the clinical diagnostic interpretation.",
keywords = "Adult, Aged, Artifacts, Contrast Media, Female, Fluorodeoxyglucose F18, Humans, Image Enhancement, Injections, Intravenous, Iothalamic Acid, Male, Middle Aged, Neoplasms, Phantoms, Imaging, Positron-Emission Tomography, Radiopharmaceuticals, Reproducibility of Results, Sensitivity and Specificity, Single-Blind Method, Subtraction Technique, Tomography, X-Ray Computed, Journal Article, Randomized Controlled Trial",
author = "Berthelsen, {A K} and S Holm and A Loft and Klausen, {T L} and F Andersen and L H{\o}jgaard",
year = "2005",
month = "10",
doi = "10.1007/s00259-005-1784-1",
language = "English",
volume = "32",
pages = "1167--75",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients

AU - Berthelsen, A K

AU - Holm, S

AU - Loft, A

AU - Klausen, T L

AU - Andersen, F

AU - Højgaard, L

PY - 2005/10

Y1 - 2005/10

N2 - PURPOSE: If the CT scan of a combined PET/CT study is performed as a full diagnostic quality CT scan including intravenous (IV) contrast agent, the quality of the joint PET/CT procedure is improved and a separate diagnostic CT scan can be avoided. CT with IV contrast can be used for PET attenuation correction, but this may result in a bias in the attenuation factors. The clinical significance of this bias has not been established. Our aim was to perform a prospective clinical study where each patient had CT performed with and without IV contrast agent to establish whether PET/CT with IV contrast can be used for PET attenuation without reducing the clinical value of the PET scan.METHODS: A uniform phantom study was used to document that the PET acquisition itself is not significantly influenced by the presence of IV contrast medium. Then, 19 patients referred to PET/CT with IV contrast underwent CT scans without, and then with contrast agent, followed by an 18F-fluorodeoxyglucose whole-body PET scan. The CT examinations were performed with identical parameters on a GE Discovery LS scanner. The PET data were reconstructed with attenuation correction based on the two CT data sets. A global comparison of standard uptake value (SUV) was performed, and SUVs in tumour, in non-tumour tissue and in the subclavian vein were calculated. Clinical evaluation of the number and location of lesions on all PET/CT scans was performed twice, blinded and in a different random order, by two independent nuclear medicine specialists.RESULTS: In all patients, the measured global SUV of PET images based on CT with IV contrast agent was higher than the global activity using non-contrast correction. The overall increase in the mean SUV (for two different conversion tables tested) was 4.5+/-2.3% and 1.6+/-0.5%, respectively. In 11/19 patients, focal uptake was identified corresponding to malignant tumours. Eight out of 11 tumours showed an increased SUVmax (2.9+/-3.1%) on the PET images reconstructed using IV contrast. The clinical evaluation performed by the two specialists comparing contrast and non-contrast CT attenuated PET images showed weighted kappa values of 0.92 (doctor A) and 0.82 (doctor B). No contrast-introduced artefacts were found.CONCLUSION: This study demonstrates that CT scans with IV contrast agent can be used for attenuation correction of the PET data in combined modality PET/CT scanning, without changing the clinical diagnostic interpretation.

AB - PURPOSE: If the CT scan of a combined PET/CT study is performed as a full diagnostic quality CT scan including intravenous (IV) contrast agent, the quality of the joint PET/CT procedure is improved and a separate diagnostic CT scan can be avoided. CT with IV contrast can be used for PET attenuation correction, but this may result in a bias in the attenuation factors. The clinical significance of this bias has not been established. Our aim was to perform a prospective clinical study where each patient had CT performed with and without IV contrast agent to establish whether PET/CT with IV contrast can be used for PET attenuation without reducing the clinical value of the PET scan.METHODS: A uniform phantom study was used to document that the PET acquisition itself is not significantly influenced by the presence of IV contrast medium. Then, 19 patients referred to PET/CT with IV contrast underwent CT scans without, and then with contrast agent, followed by an 18F-fluorodeoxyglucose whole-body PET scan. The CT examinations were performed with identical parameters on a GE Discovery LS scanner. The PET data were reconstructed with attenuation correction based on the two CT data sets. A global comparison of standard uptake value (SUV) was performed, and SUVs in tumour, in non-tumour tissue and in the subclavian vein were calculated. Clinical evaluation of the number and location of lesions on all PET/CT scans was performed twice, blinded and in a different random order, by two independent nuclear medicine specialists.RESULTS: In all patients, the measured global SUV of PET images based on CT with IV contrast agent was higher than the global activity using non-contrast correction. The overall increase in the mean SUV (for two different conversion tables tested) was 4.5+/-2.3% and 1.6+/-0.5%, respectively. In 11/19 patients, focal uptake was identified corresponding to malignant tumours. Eight out of 11 tumours showed an increased SUVmax (2.9+/-3.1%) on the PET images reconstructed using IV contrast. The clinical evaluation performed by the two specialists comparing contrast and non-contrast CT attenuated PET images showed weighted kappa values of 0.92 (doctor A) and 0.82 (doctor B). No contrast-introduced artefacts were found.CONCLUSION: This study demonstrates that CT scans with IV contrast agent can be used for attenuation correction of the PET data in combined modality PET/CT scanning, without changing the clinical diagnostic interpretation.

KW - Adult

KW - Aged

KW - Artifacts

KW - Contrast Media

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Image Enhancement

KW - Injections, Intravenous

KW - Iothalamic Acid

KW - Male

KW - Middle Aged

KW - Neoplasms

KW - Phantoms, Imaging

KW - Positron-Emission Tomography

KW - Radiopharmaceuticals

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Single-Blind Method

KW - Subtraction Technique

KW - Tomography, X-Ray Computed

KW - Journal Article

KW - Randomized Controlled Trial

U2 - 10.1007/s00259-005-1784-1

DO - 10.1007/s00259-005-1784-1

M3 - Journal article

VL - 32

SP - 1167

EP - 1175

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 10

ER -

ID: 165882182