Mutations in the AXIN1 gene in advanced prostate cancer
Research output: Contribution to journal › Journal article › Research › peer-review
The Wnt signalling pathway directs aspects of embryogenesis and is thought to contribute to maintenance of certain stem cell populations. Disruption of the pathway has been observed in many different tumour types. In bowel, stomach, and endometrial cancer, this is usually due to mutation of genes encoding Wnt pathway components APC or beta-catenin. Such mutations are rare in hepatocellular carcinomas and medulloblastomas with Wnt pathway dysfunction, and there, mutation in genes for other Wnt molecules, such as Axin, is more frequently found.
Original language | English |
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Journal | European Urology Supplements |
Volume | 56 |
Issue number | 3 |
Pages (from-to) | 486-94 |
Number of pages | 9 |
ISSN | 1569-9056 |
DOIs | |
Publication status | Published - 1 Sep 2009 |
- Aged, Aged, 80 and over, Genes, APC, Humans, Male, Middle Aged, Mutation, Prostatic Neoplasms, Repressor Proteins, Signal Transduction, Wnt Proteins, beta Catenin
Research areas
ID: 33572511