Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot
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Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot. / Jansen, Rasmus Bo; Christensen, Tomas Møller; Bülow, Jens; Rørdam, Lene; Jørgensen, Niklas Rye; Svendsen, Ole Lander.
In: Journal of Diabetes Research, Vol. 2018, 5647981, 2018, p. 1-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot
AU - Jansen, Rasmus Bo
AU - Christensen, Tomas Møller
AU - Bülow, Jens
AU - Rørdam, Lene
AU - Jørgensen, Niklas Rye
AU - Svendsen, Ole Lander
PY - 2018
Y1 - 2018
N2 - Objective: Due to the localized nature of Charcot foot, systemically altered levels of inflammation markers can be difficult to measure. The aim of this study was to investigate whether it is possible to detect an arteriovenous (A-V) flux in any locally produced inflammatory biomarkers from an acute Charcot foot by comparing local and systemic measurements.Methods: We included patients with acute diabetic Charcot foot. Blood was sampled from the vena saphena magna on the distal part of the crus bilaterally as well as from the arteria radialis. To minimize the A-V shunting effect, the feet were externally cooled with ice water prior to resampling.Results: Both before and after cooling, the A-V flux of interleukin-6 (IL-6) between the Charcot feet and the arterial level was significantly higher than the flux between the healthy feet and the arterial level (Δvaluebefore: 7.25 versus 0.41 pg/mL, resp., p = 0.008; Δvalueafter: 10.04 versus 1.68 pg/mL, resp., p = 0.032). There were no differences in the fluxes for other markers of inflammation.Conclusion: We have found an increased A-V flux of IL-6 in the acute diabetic Charcot foot compared to the healthy foot in the same patients.
AB - Objective: Due to the localized nature of Charcot foot, systemically altered levels of inflammation markers can be difficult to measure. The aim of this study was to investigate whether it is possible to detect an arteriovenous (A-V) flux in any locally produced inflammatory biomarkers from an acute Charcot foot by comparing local and systemic measurements.Methods: We included patients with acute diabetic Charcot foot. Blood was sampled from the vena saphena magna on the distal part of the crus bilaterally as well as from the arteria radialis. To minimize the A-V shunting effect, the feet were externally cooled with ice water prior to resampling.Results: Both before and after cooling, the A-V flux of interleukin-6 (IL-6) between the Charcot feet and the arterial level was significantly higher than the flux between the healthy feet and the arterial level (Δvaluebefore: 7.25 versus 0.41 pg/mL, resp., p = 0.008; Δvalueafter: 10.04 versus 1.68 pg/mL, resp., p = 0.032). There were no differences in the fluxes for other markers of inflammation.Conclusion: We have found an increased A-V flux of IL-6 in the acute diabetic Charcot foot compared to the healthy foot in the same patients.
KW - Arthropathy, Neurogenic/blood
KW - Biomarkers/blood
KW - Bone Resorption/blood
KW - Case-Control Studies
KW - Diabetic Foot/blood
KW - Female
KW - Humans
KW - Inflammation Mediators/blood
KW - Interleukin-6/blood
KW - Male
KW - Middle Aged
KW - Up-Regulation
U2 - 10.1155/2018/5647981
DO - 10.1155/2018/5647981
M3 - Journal article
C2 - 30155488
VL - 2018
SP - 1
EP - 9
JO - Journal of Diabetes Research
JF - Journal of Diabetes Research
SN - 2314-6745
M1 - 5647981
ER -
ID: 216308083