Introducing the hypothome: a way to integrate predicted proteins in interactomes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Introducing the hypothome : a way to integrate predicted proteins in interactomes. / Madsen, Claus Desler; Zambach, Sine; Suravajhala, Prashanth; Rasmussen, Lene Juel.

In: International Journal of Bioinformatics Research and Applications, Vol. 10, No. 6, 2014, p. 647-52.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Madsen, CD, Zambach, S, Suravajhala, P & Rasmussen, LJ 2014, 'Introducing the hypothome: a way to integrate predicted proteins in interactomes', International Journal of Bioinformatics Research and Applications, vol. 10, no. 6, pp. 647-52. https://doi.org/10.1504/IJBRA.2014.065247

APA

Madsen, C. D., Zambach, S., Suravajhala, P., & Rasmussen, L. J. (2014). Introducing the hypothome: a way to integrate predicted proteins in interactomes. International Journal of Bioinformatics Research and Applications, 10(6), 647-52. https://doi.org/10.1504/IJBRA.2014.065247

Vancouver

Madsen CD, Zambach S, Suravajhala P, Rasmussen LJ. Introducing the hypothome: a way to integrate predicted proteins in interactomes. International Journal of Bioinformatics Research and Applications. 2014;10(6):647-52. https://doi.org/10.1504/IJBRA.2014.065247

Author

Madsen, Claus Desler ; Zambach, Sine ; Suravajhala, Prashanth ; Rasmussen, Lene Juel. / Introducing the hypothome : a way to integrate predicted proteins in interactomes. In: International Journal of Bioinformatics Research and Applications. 2014 ; Vol. 10, No. 6. pp. 647-52.

Bibtex

@article{f7c2a7651d244e999f786f7b5d3f444b,
title = "Introducing the hypothome: a way to integrate predicted proteins in interactomes",
abstract = "An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that are only predicted into interactomes. The disadvantage of doing so is the risk of devaluing the definition of interactomes. By adding proteins that have only been predicted, an interactome can no longer be classified as experimentally verified and the integrity of the interactome will be endured. Therefore, we propose the term 'hypothome' (collection of hypothetical interactions of predicted proteins). The purpose of such a term is to provide a denotation to the interactome concept allowing the interaction of predicted proteins without devaluing the integrity of the interactome. We define a rule-set for a hypothome and have integrated the predicted protein interaction partners to the hypothetical protein. EAW74251 is an example for the usage of a hypothome.",
author = "Madsen, {Claus Desler} and Sine Zambach and Prashanth Suravajhala and Rasmussen, {Lene Juel}",
year = "2014",
doi = "10.1504/IJBRA.2014.065247",
language = "English",
volume = "10",
pages = "647--52",
journal = "International Journal of Bioinformatics Research and Applications",
issn = "1744-5485",
publisher = "Inderscience Publishers",
number = "6",

}

RIS

TY - JOUR

T1 - Introducing the hypothome

T2 - a way to integrate predicted proteins in interactomes

AU - Madsen, Claus Desler

AU - Zambach, Sine

AU - Suravajhala, Prashanth

AU - Rasmussen, Lene Juel

PY - 2014

Y1 - 2014

N2 - An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that are only predicted into interactomes. The disadvantage of doing so is the risk of devaluing the definition of interactomes. By adding proteins that have only been predicted, an interactome can no longer be classified as experimentally verified and the integrity of the interactome will be endured. Therefore, we propose the term 'hypothome' (collection of hypothetical interactions of predicted proteins). The purpose of such a term is to provide a denotation to the interactome concept allowing the interaction of predicted proteins without devaluing the integrity of the interactome. We define a rule-set for a hypothome and have integrated the predicted protein interaction partners to the hypothetical protein. EAW74251 is an example for the usage of a hypothome.

AB - An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that are only predicted into interactomes. The disadvantage of doing so is the risk of devaluing the definition of interactomes. By adding proteins that have only been predicted, an interactome can no longer be classified as experimentally verified and the integrity of the interactome will be endured. Therefore, we propose the term 'hypothome' (collection of hypothetical interactions of predicted proteins). The purpose of such a term is to provide a denotation to the interactome concept allowing the interaction of predicted proteins without devaluing the integrity of the interactome. We define a rule-set for a hypothome and have integrated the predicted protein interaction partners to the hypothetical protein. EAW74251 is an example for the usage of a hypothome.

U2 - 10.1504/IJBRA.2014.065247

DO - 10.1504/IJBRA.2014.065247

M3 - Journal article

C2 - 25335568

VL - 10

SP - 647

EP - 652

JO - International Journal of Bioinformatics Research and Applications

JF - International Journal of Bioinformatics Research and Applications

SN - 1744-5485

IS - 6

ER -

ID: 132942768