Standard
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk : a case-control study. / Johnson, Nichola; Dudbridge, Frank; Orr, Nick; Gibson, Lorna; Jones, Michael E; Schoemaker, Minouk J; Folkerd, Elizabeth J; Haynes, Ben P; Hopper, John L; Southey, Melissa C; Dite, Gillian S; Apicella, Carmel; Schmidt, Marjanka K; Broeks, Annegien; Van T Veer, Laura J; Atsma, Femke; Muir, Kenneth; Lophatananon, Artitaya; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Renner, Stefan P; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Miller, Nicola; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Guénel, Pascal; Truong, Therese; Cordina, Emilie; Menegaux, Florence; Bojesen, Stig E; Nordestgaard, Børge G; Flyger, Henrik; Milne, Roger; Zamora, M Pilar; Arias Perez, Jose Ignacio; Benitez, Javier; Bernstein, Leslie; Anton-Culver, Hoda; Ziogas, Argyrios; Clarke Dur, Christina; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Dieffenbach, Aida Karina; Meindl, Alfons; Heil, Joerg; Bartram, Claus R; Schmutzler, Rita K; Brauch, Hiltrud; Justenhoven, Christina; Ko, Yon-Dschun; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Matsuo, Keitaro; Dörk, Thilo; Bogdanova, Natalia V; Antonenkova, Natalia N; Lindblom, Annika; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Chenevix-Trench, Georgia; Beesley, Jonathan; Wu, Anna H; Van den Berg, David; Tseng, Chiu-Chen; Lambrechts, Diether; Smeets, Dominiek; Neven, Patrick; Wildiers, Hans; Chang-Claude, Jenny; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Pensotti, Valeria; Couch, Fergus J; Olson, Janet E; Wang, Xianshu; Fredericksen, Zachary; Pankratz, Vernon S; Giles, Graham G; Severi, Gianluca; Baglietto, Laura; Haiman, Chris; Simard, Jacques; Goldberg, Mark S; Labrèche, France; Dumont, Martine; Soucy, Penny; Teo, Soo; Yip, Cheng Har; Phuah, Sze Yee; Cornes, Belinda K; Kristensen, Vessela N; Grenaker Alnæs, Grethe; Børresen-Dale, Anne-Lise; Zheng, Wei; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Devillee, Peter; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Sherman, Mark E; Hall, Per; Schoof, Nils; Hooning, Maartje; Hollestelle, Antoinette; Oldenburg, Rogier A; Tilanus-Linthorst, Madeleine; Liu, Jianjun; Cox, Angie; Brock, Ian W; Reed, Malcolm Wr; Cross, Simon S; Blot, William; Signorello, Lisa B; Pharoah, Paul Dp; Dunning, Alison M; Shah, Mitul; Kang, Daehee; Noh, Dong-Young; Park, Sue K; Choi, Ji-Yeob; Hartman, Mikael; Miao, Hui; Lim, Wei Yen; Tang, Anthony; Hamann, Ute; Försti, Asta; Rüdiger, Thomas; Ulmer, Hans Ulrich; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Slager, Susan; Toland, Amanda E; Vachon, Celine; Yannoukakos, Drakoulis; Shen, Chen-Yang; Yu, Jyh-Cherng; Huang, Chiun-Sheng; Hou, Ming-Feng; González-Neira, Anna; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Dennis, Joe; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Jean; Easton, Douglas F; García-Closas, Montserrat; Dowsett, Mitch; Ashworth, Alan; Swerdlow, Anthony J; Peto, Julian; Dos Santos Silva, Isabel; Fletcher, Olivia.
In:
Breast cancer research : BCR, Vol. 16, No. 3, 2014, p. R51.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Johnson, N, Dudbridge, F, Orr, N, Gibson, L, Jones, ME, Schoemaker, MJ, Folkerd, EJ, Haynes, BP, Hopper, JL, Southey, MC, Dite, GS, Apicella, C, Schmidt, MK, Broeks, A, Van T Veer, LJ, Atsma, F, Muir, K, Lophatananon, A, Fasching, PA, Beckmann, MW, Ekici, AB, Renner, SP, Sawyer, E, Tomlinson, I, Kerin, M, Miller, N, Burwinkel, B, Marme, F, Schneeweiss, A, Sohn, C, Guénel, P, Truong, T, Cordina, E, Menegaux, F
, Bojesen, SE, Nordestgaard, BG, Flyger, H, Milne, R, Zamora, MP, Arias Perez, JI, Benitez, J, Bernstein, L, Anton-Culver, H, Ziogas, A, Clarke Dur, C, Brenner, H, Müller, H, Arndt, V, Dieffenbach, AK, Meindl, A, Heil, J, Bartram, CR, Schmutzler, RK, Brauch, H, Justenhoven, C, Ko, Y-D, Nevanlinna, H, Muranen, TA, Aittomäki, K, Blomqvist, C, Matsuo, K, Dörk, T, Bogdanova, NV, Antonenkova, NN, Lindblom, A, Mannermaa, A, Kataja, V, Kosma, V-M, Hartikainen, JM, Chenevix-Trench, G, Beesley, J, Wu, AH, Van den Berg, D, Tseng, C-C, Lambrechts, D, Smeets, D, Neven, P, Wildiers, H, Chang-Claude, J, Rudolph, A, Nickels, S, Flesch-Janys, D, Radice, P, Peterlongo, P, Bonanni, B, Pensotti, V, Couch, FJ, Olson, JE, Wang, X, Fredericksen, Z, Pankratz, VS, Giles, GG, Severi, G, Baglietto, L, Haiman, C, Simard, J, Goldberg, MS, Labrèche, F, Dumont, M, Soucy, P, Teo, S, Yip, CH, Phuah, SY, Cornes, BK, Kristensen, VN, Grenaker Alnæs, G, Børresen-Dale, A-L, Zheng, W, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Andrulis, IL, Knight, JA, Glendon, G, Mulligan, AM, Devillee, P, Figueroa, J, Chanock, SJ, Lissowska, J, Sherman, ME, Hall, P, Schoof, N, Hooning, M, Hollestelle, A, Oldenburg, RA, Tilanus-Linthorst, M, Liu, J, Cox, A, Brock, IW, Reed, MW, Cross, SS, Blot, W, Signorello, LB, Pharoah, PD, Dunning, AM, Shah, M, Kang, D, Noh, D-Y, Park, SK, Choi, J-Y, Hartman, M, Miao, H, Lim, WY, Tang, A, Hamann, U, Försti, A, Rüdiger, T, Ulmer, HU, Jakubowska, A, Lubinski, J, Jaworska-Bieniek, K, Durda, K, Sangrajrang, S, Gaborieau, V, Brennan, P, McKay, J, Slager, S, Toland, AE, Vachon, C, Yannoukakos, D, Shen, C-Y, Yu, J-C, Huang, C-S, Hou, M-F, González-Neira, A, Tessier, DC, Vincent, D, Bacot, F, Luccarini, C, Dennis, J, Michailidou, K, Bolla, MK, Wang, J, Easton, DF, García-Closas, M, Dowsett, M, Ashworth, A, Swerdlow, AJ, Peto, J, Dos Santos Silva, I & Fletcher, O 2014, '
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study',
Breast cancer research : BCR, vol. 16, no. 3, pp. R51.
https://doi.org/10.1186/bcr3662APA
Johnson, N., Dudbridge, F., Orr, N., Gibson, L., Jones, M. E., Schoemaker, M. J., Folkerd, E. J., Haynes, B. P., Hopper, J. L., Southey, M. C., Dite, G. S., Apicella, C., Schmidt, M. K., Broeks, A., Van T Veer, L. J., Atsma, F., Muir, K., Lophatananon, A., Fasching, P. A., ... Fletcher, O. (2014).
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.
Breast cancer research : BCR,
16(3), R51.
https://doi.org/10.1186/bcr3662Vancouver
Johnson N, Dudbridge F, Orr N, Gibson L, Jones ME, Schoemaker MJ et al.
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.
Breast cancer research : BCR. 2014;16(3):R51.
https://doi.org/10.1186/bcr3662Author
Johnson, Nichola ; Dudbridge, Frank ; Orr, Nick ; Gibson, Lorna ; Jones, Michael E ; Schoemaker, Minouk J ; Folkerd, Elizabeth J ; Haynes, Ben P ; Hopper, John L ; Southey, Melissa C ; Dite, Gillian S ; Apicella, Carmel ; Schmidt, Marjanka K ; Broeks, Annegien ; Van T Veer, Laura J ; Atsma, Femke ; Muir, Kenneth ; Lophatananon, Artitaya ; Fasching, Peter A ; Beckmann, Matthias W ; Ekici, Arif B ; Renner, Stefan P ; Sawyer, Elinor ; Tomlinson, Ian ; Kerin, Michael ; Miller, Nicola ; Burwinkel, Barbara ; Marme, Frederik ; Schneeweiss, Andreas ; Sohn, Christof ; Guénel, Pascal ; Truong, Therese ; Cordina, Emilie ; Menegaux, Florence ; Bojesen, Stig E ; Nordestgaard, Børge G ; Flyger, Henrik ; Milne, Roger ; Zamora, M Pilar ; Arias Perez, Jose Ignacio ; Benitez, Javier ; Bernstein, Leslie ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Clarke Dur, Christina ; Brenner, Hermann ; Müller, Heiko ; Arndt, Volker ; Dieffenbach, Aida Karina ; Meindl, Alfons ; Heil, Joerg ; Bartram, Claus R ; Schmutzler, Rita K ; Brauch, Hiltrud ; Justenhoven, Christina ; Ko, Yon-Dschun ; Nevanlinna, Heli ; Muranen, Taru A ; Aittomäki, Kristiina ; Blomqvist, Carl ; Matsuo, Keitaro ; Dörk, Thilo ; Bogdanova, Natalia V ; Antonenkova, Natalia N ; Lindblom, Annika ; Mannermaa, Arto ; Kataja, Vesa ; Kosma, Veli-Matti ; Hartikainen, Jaana M ; Chenevix-Trench, Georgia ; Beesley, Jonathan ; Wu, Anna H ; Van den Berg, David ; Tseng, Chiu-Chen ; Lambrechts, Diether ; Smeets, Dominiek ; Neven, Patrick ; Wildiers, Hans ; Chang-Claude, Jenny ; Rudolph, Anja ; Nickels, Stefan ; Flesch-Janys, Dieter ; Radice, Paolo ; Peterlongo, Paolo ; Bonanni, Bernardo ; Pensotti, Valeria ; Couch, Fergus J ; Olson, Janet E ; Wang, Xianshu ; Fredericksen, Zachary ; Pankratz, Vernon S ; Giles, Graham G ; Severi, Gianluca ; Baglietto, Laura ; Haiman, Chris ; Simard, Jacques ; Goldberg, Mark S ; Labrèche, France ; Dumont, Martine ; Soucy, Penny ; Teo, Soo ; Yip, Cheng Har ; Phuah, Sze Yee ; Cornes, Belinda K ; Kristensen, Vessela N ; Grenaker Alnæs, Grethe ; Børresen-Dale, Anne-Lise ; Zheng, Wei ; Winqvist, Robert ; Pylkäs, Katri ; Jukkola-Vuorinen, Arja ; Grip, Mervi ; Andrulis, Irene L ; Knight, Julia A ; Glendon, Gord ; Mulligan, Anna Marie ; Devillee, Peter ; Figueroa, Jonine ; Chanock, Stephen J ; Lissowska, Jolanta ; Sherman, Mark E ; Hall, Per ; Schoof, Nils ; Hooning, Maartje ; Hollestelle, Antoinette ; Oldenburg, Rogier A ; Tilanus-Linthorst, Madeleine ; Liu, Jianjun ; Cox, Angie ; Brock, Ian W ; Reed, Malcolm Wr ; Cross, Simon S ; Blot, William ; Signorello, Lisa B ; Pharoah, Paul Dp ; Dunning, Alison M ; Shah, Mitul ; Kang, Daehee ; Noh, Dong-Young ; Park, Sue K ; Choi, Ji-Yeob ; Hartman, Mikael ; Miao, Hui ; Lim, Wei Yen ; Tang, Anthony ; Hamann, Ute ; Försti, Asta ; Rüdiger, Thomas ; Ulmer, Hans Ulrich ; Jakubowska, Anna ; Lubinski, Jan ; Jaworska-Bieniek, Katarzyna ; Durda, Katarzyna ; Sangrajrang, Suleeporn ; Gaborieau, Valerie ; Brennan, Paul ; McKay, James ; Slager, Susan ; Toland, Amanda E ; Vachon, Celine ; Yannoukakos, Drakoulis ; Shen, Chen-Yang ; Yu, Jyh-Cherng ; Huang, Chiun-Sheng ; Hou, Ming-Feng ; González-Neira, Anna ; Tessier, Daniel C ; Vincent, Daniel ; Bacot, Francois ; Luccarini, Craig ; Dennis, Joe ; Michailidou, Kyriaki ; Bolla, Manjeet K ; Wang, Jean ; Easton, Douglas F ; García-Closas, Montserrat ; Dowsett, Mitch ; Ashworth, Alan ; Swerdlow, Anthony J ; Peto, Julian ; Dos Santos Silva, Isabel ; Fletcher, Olivia. / Genetic variation at CYP3A is associated with age at menarche and breast cancer risk : a case-control study. In: Breast cancer research : BCR. 2014 ; Vol. 16, No. 3. pp. R51.
Bibtex
@article{4ca2afb60a494dfe9948dd0d014f5a4f,
title = "Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study",
abstract = "INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age <=50 years.METHODS: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.RESULTS: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (Ptrend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (Ptrend = 0.005) but not cases (Ptrend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (Phet = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age >=15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; Ptrend = 0.002) but not for those who had their menarche age <=11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; Ptrend = 0.29).CONCLUSIONS: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.",
author = "Nichola Johnson and Frank Dudbridge and Nick Orr and Lorna Gibson and Jones, {Michael E} and Schoemaker, {Minouk J} and Folkerd, {Elizabeth J} and Haynes, {Ben P} and Hopper, {John L} and Southey, {Melissa C} and Dite, {Gillian S} and Carmel Apicella and Schmidt, {Marjanka K} and Annegien Broeks and {Van T Veer}, {Laura J} and Femke Atsma and Kenneth Muir and Artitaya Lophatananon and Fasching, {Peter A} and Beckmann, {Matthias W} and Ekici, {Arif B} and Renner, {Stefan P} and Elinor Sawyer and Ian Tomlinson and Michael Kerin and Nicola Miller and Barbara Burwinkel and Frederik Marme and Andreas Schneeweiss and Christof Sohn and Pascal Gu{\'e}nel and Therese Truong and Emilie Cordina and Florence Menegaux and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G} and Henrik Flyger and Roger Milne and Zamora, {M Pilar} and {Arias Perez}, {Jose Ignacio} and Javier Benitez and Leslie Bernstein and Hoda Anton-Culver and Argyrios Ziogas and {Clarke Dur}, Christina and Hermann Brenner and Heiko M{\"u}ller and Volker Arndt and Dieffenbach, {Aida Karina} and Alfons Meindl and Joerg Heil and Bartram, {Claus R} and Schmutzler, {Rita K} and Hiltrud Brauch and Christina Justenhoven and Yon-Dschun Ko and Heli Nevanlinna and Muranen, {Taru A} and Kristiina Aittom{\"a}ki and Carl Blomqvist and Keitaro Matsuo and Thilo D{\"o}rk and Bogdanova, {Natalia V} and Antonenkova, {Natalia N} and Annika Lindblom and Arto Mannermaa and Vesa Kataja and Veli-Matti Kosma and Hartikainen, {Jaana M} and Georgia Chenevix-Trench and Jonathan Beesley and Wu, {Anna H} and {Van den Berg}, David and Chiu-Chen Tseng and Diether Lambrechts and Dominiek Smeets and Patrick Neven and Hans Wildiers and Jenny Chang-Claude and Anja Rudolph and Stefan Nickels and Dieter Flesch-Janys and Paolo Radice and Paolo Peterlongo and Bernardo Bonanni and Valeria Pensotti and Couch, {Fergus J} and Olson, {Janet E} and Xianshu Wang and Zachary Fredericksen and Pankratz, {Vernon S} and Giles, {Graham G} and Gianluca Severi and Laura Baglietto and Chris Haiman and Jacques Simard and Goldberg, {Mark S} and France Labr{\`e}che and Martine Dumont and Penny Soucy and Soo Teo and Yip, {Cheng Har} and Phuah, {Sze Yee} and Cornes, {Belinda K} and Kristensen, {Vessela N} and {Grenaker Aln{\ae}s}, Grethe and Anne-Lise B{\o}rresen-Dale and Wei Zheng and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Andrulis, {Irene L} and Knight, {Julia A} and Gord Glendon and Mulligan, {Anna Marie} and Peter Devillee and Jonine Figueroa and Chanock, {Stephen J} and Jolanta Lissowska and Sherman, {Mark E} and Per Hall and Nils Schoof and Maartje Hooning and Antoinette Hollestelle and Oldenburg, {Rogier A} and Madeleine Tilanus-Linthorst and Jianjun Liu and Angie Cox and Brock, {Ian W} and Reed, {Malcolm Wr} and Cross, {Simon S} and William Blot and Signorello, {Lisa B} and Pharoah, {Paul Dp} and Dunning, {Alison M} and Mitul Shah and Daehee Kang and Dong-Young Noh and Park, {Sue K} and Ji-Yeob Choi and Mikael Hartman and Hui Miao and Lim, {Wei Yen} and Anthony Tang and Ute Hamann and Asta F{\"o}rsti and Thomas R{\"u}diger and Ulmer, {Hans Ulrich} and Anna Jakubowska and Jan Lubinski and Katarzyna Jaworska-Bieniek and Katarzyna Durda and Suleeporn Sangrajrang and Valerie Gaborieau and Paul Brennan and James McKay and Susan Slager and Toland, {Amanda E} and Celine Vachon and Drakoulis Yannoukakos and Chen-Yang Shen and Jyh-Cherng Yu and Chiun-Sheng Huang and Ming-Feng Hou and Anna Gonz{\'a}lez-Neira and Tessier, {Daniel C} and Daniel Vincent and Francois Bacot and Craig Luccarini and Joe Dennis and Kyriaki Michailidou and Bolla, {Manjeet K} and Jean Wang and Easton, {Douglas F} and Montserrat Garc{\'i}a-Closas and Mitch Dowsett and Alan Ashworth and Swerdlow, {Anthony J} and Julian Peto and {Dos Santos Silva}, Isabel and Olivia Fletcher",
year = "2014",
doi = "10.1186/bcr3662",
language = "English",
volume = "16",
pages = "R51",
journal = "Breast Cancer Research",
issn = "1465-5411",
publisher = "BioMed Central Ltd.",
number = "3",
}
RIS
TY - JOUR
T1 - Genetic variation at CYP3A is associated with age at menarche and breast cancer risk
T2 - a case-control study
AU - Johnson, Nichola
AU - Dudbridge, Frank
AU - Orr, Nick
AU - Gibson, Lorna
AU - Jones, Michael E
AU - Schoemaker, Minouk J
AU - Folkerd, Elizabeth J
AU - Haynes, Ben P
AU - Hopper, John L
AU - Southey, Melissa C
AU - Dite, Gillian S
AU - Apicella, Carmel
AU - Schmidt, Marjanka K
AU - Broeks, Annegien
AU - Van T Veer, Laura J
AU - Atsma, Femke
AU - Muir, Kenneth
AU - Lophatananon, Artitaya
AU - Fasching, Peter A
AU - Beckmann, Matthias W
AU - Ekici, Arif B
AU - Renner, Stefan P
AU - Sawyer, Elinor
AU - Tomlinson, Ian
AU - Kerin, Michael
AU - Miller, Nicola
AU - Burwinkel, Barbara
AU - Marme, Frederik
AU - Schneeweiss, Andreas
AU - Sohn, Christof
AU - Guénel, Pascal
AU - Truong, Therese
AU - Cordina, Emilie
AU - Menegaux, Florence
AU - Bojesen, Stig E
AU - Nordestgaard, Børge G
AU - Flyger, Henrik
AU - Milne, Roger
AU - Zamora, M Pilar
AU - Arias Perez, Jose Ignacio
AU - Benitez, Javier
AU - Bernstein, Leslie
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Clarke Dur, Christina
AU - Brenner, Hermann
AU - Müller, Heiko
AU - Arndt, Volker
AU - Dieffenbach, Aida Karina
AU - Meindl, Alfons
AU - Heil, Joerg
AU - Bartram, Claus R
AU - Schmutzler, Rita K
AU - Brauch, Hiltrud
AU - Justenhoven, Christina
AU - Ko, Yon-Dschun
AU - Nevanlinna, Heli
AU - Muranen, Taru A
AU - Aittomäki, Kristiina
AU - Blomqvist, Carl
AU - Matsuo, Keitaro
AU - Dörk, Thilo
AU - Bogdanova, Natalia V
AU - Antonenkova, Natalia N
AU - Lindblom, Annika
AU - Mannermaa, Arto
AU - Kataja, Vesa
AU - Kosma, Veli-Matti
AU - Hartikainen, Jaana M
AU - Chenevix-Trench, Georgia
AU - Beesley, Jonathan
AU - Wu, Anna H
AU - Van den Berg, David
AU - Tseng, Chiu-Chen
AU - Lambrechts, Diether
AU - Smeets, Dominiek
AU - Neven, Patrick
AU - Wildiers, Hans
AU - Chang-Claude, Jenny
AU - Rudolph, Anja
AU - Nickels, Stefan
AU - Flesch-Janys, Dieter
AU - Radice, Paolo
AU - Peterlongo, Paolo
AU - Bonanni, Bernardo
AU - Pensotti, Valeria
AU - Couch, Fergus J
AU - Olson, Janet E
AU - Wang, Xianshu
AU - Fredericksen, Zachary
AU - Pankratz, Vernon S
AU - Giles, Graham G
AU - Severi, Gianluca
AU - Baglietto, Laura
AU - Haiman, Chris
AU - Simard, Jacques
AU - Goldberg, Mark S
AU - Labrèche, France
AU - Dumont, Martine
AU - Soucy, Penny
AU - Teo, Soo
AU - Yip, Cheng Har
AU - Phuah, Sze Yee
AU - Cornes, Belinda K
AU - Kristensen, Vessela N
AU - Grenaker Alnæs, Grethe
AU - Børresen-Dale, Anne-Lise
AU - Zheng, Wei
AU - Winqvist, Robert
AU - Pylkäs, Katri
AU - Jukkola-Vuorinen, Arja
AU - Grip, Mervi
AU - Andrulis, Irene L
AU - Knight, Julia A
AU - Glendon, Gord
AU - Mulligan, Anna Marie
AU - Devillee, Peter
AU - Figueroa, Jonine
AU - Chanock, Stephen J
AU - Lissowska, Jolanta
AU - Sherman, Mark E
AU - Hall, Per
AU - Schoof, Nils
AU - Hooning, Maartje
AU - Hollestelle, Antoinette
AU - Oldenburg, Rogier A
AU - Tilanus-Linthorst, Madeleine
AU - Liu, Jianjun
AU - Cox, Angie
AU - Brock, Ian W
AU - Reed, Malcolm Wr
AU - Cross, Simon S
AU - Blot, William
AU - Signorello, Lisa B
AU - Pharoah, Paul Dp
AU - Dunning, Alison M
AU - Shah, Mitul
AU - Kang, Daehee
AU - Noh, Dong-Young
AU - Park, Sue K
AU - Choi, Ji-Yeob
AU - Hartman, Mikael
AU - Miao, Hui
AU - Lim, Wei Yen
AU - Tang, Anthony
AU - Hamann, Ute
AU - Försti, Asta
AU - Rüdiger, Thomas
AU - Ulmer, Hans Ulrich
AU - Jakubowska, Anna
AU - Lubinski, Jan
AU - Jaworska-Bieniek, Katarzyna
AU - Durda, Katarzyna
AU - Sangrajrang, Suleeporn
AU - Gaborieau, Valerie
AU - Brennan, Paul
AU - McKay, James
AU - Slager, Susan
AU - Toland, Amanda E
AU - Vachon, Celine
AU - Yannoukakos, Drakoulis
AU - Shen, Chen-Yang
AU - Yu, Jyh-Cherng
AU - Huang, Chiun-Sheng
AU - Hou, Ming-Feng
AU - González-Neira, Anna
AU - Tessier, Daniel C
AU - Vincent, Daniel
AU - Bacot, Francois
AU - Luccarini, Craig
AU - Dennis, Joe
AU - Michailidou, Kyriaki
AU - Bolla, Manjeet K
AU - Wang, Jean
AU - Easton, Douglas F
AU - García-Closas, Montserrat
AU - Dowsett, Mitch
AU - Ashworth, Alan
AU - Swerdlow, Anthony J
AU - Peto, Julian
AU - Dos Santos Silva, Isabel
AU - Fletcher, Olivia
PY - 2014
Y1 - 2014
N2 - INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age <=50 years.METHODS: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.RESULTS: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (Ptrend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (Ptrend = 0.005) but not cases (Ptrend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (Phet = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age >=15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; Ptrend = 0.002) but not for those who had their menarche age <=11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; Ptrend = 0.29).CONCLUSIONS: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.
AB - INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age <=50 years.METHODS: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.RESULTS: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (Ptrend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (Ptrend = 0.005) but not cases (Ptrend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (Phet = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age >=15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; Ptrend = 0.002) but not for those who had their menarche age <=11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; Ptrend = 0.29).CONCLUSIONS: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.
U2 - 10.1186/bcr3662
DO - 10.1186/bcr3662
M3 - Journal article
C2 - 24887515
VL - 16
SP - R51
JO - Breast Cancer Research
JF - Breast Cancer Research
SN - 1465-5411
IS - 3
ER -
