Extracellular matrix component signaling in cancer

Research output: Contribution to journalReviewResearchpeer-review

Hinke A. B. Multhaupt, Birgit Leitinger, Donald Gullberg, John R. Couchman

Cell responses to the extracellular matrix depend on specific signaling events. These are important from early development, through differentiation and tissue homeostasis, immune surveillance, and disease pathogenesis. Signaling not only regulates cell adhesion cytoskeletal organization and motility but also provides survival and proliferation cues. The major classes of cell surface receptors for matrix macromols. are the integrins, discoidin domain receptors, and transmembrane proteoglycans such as syndecans and CD44. Cells respond not only to specific ligands, such as collagen, fibronectin, or basement membrane glycoproteins, but also in terms of matrix rigidity. This can regulate the release and subsequent biol. activity of matrix-bound growth factors, for example, transforming growth factor-β. In the environment of tumors, there may be changes in cell populations and their receptor profiles as well as matrix constitution and protein crosslinking. Here we summarize roles of the three major matrix receptor types, with emphasis on how they function in tumor progression. [on SciFinder(R)]
Original languageEnglish
JournalAdvanced Drug Delivery Reviews
Volume97
Pages (from-to)28–40
ISSN0169-409X
DOIs
Publication statusPublished - 1 Feb 2016

Bibliographical note

M1 - Copyright (C) 2015 American Chemical Society (ACS). All Rights Reserved.

CAPLUS AN 2015:1757218(Journal)

ID: 150700795