Standard
Body mass index and breast cancer survival : a Mendelian randomization analysis. / Guo, Qi; Burgess, Stephen; Turman, Constance; Bolla, Manjeet K; Wang, Qin; Lush, Michael; Abraham, Jean; Aittomäki, Kristiina; Andrulis, Irene L; Apicella, Carmel; Arndt, Volker; Barrdahl, Myrto; Benitez, Javier; Berg, Christine D; Blomqvist, Carl; Bojesen, Stig E; Bonanni, Bernardo; Brand, Judith S; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Caldas, Carlos; Campa, Daniele; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J; Chin, Suet-Feung; Couch, Fergus J; Cox, Angela; Cross, Simon S; Cybulski, Cezary; Czene, Kamila; Darabi, Hatef; Devilee, Peter; Diver, W Ryan; Dunning, Alison M; Earl, Helena M; Eccles, Diana M; Ekici, Arif B; Eriksson, Mikael; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine; Flesch-Janys, Dieter; Flyger, Henrik; Gapstur, Susan M; Gaudet, Mia M; Giles, Graham G; Glendon, Gord; Grip, Mervi; Gronwald, Jacek; Haeberle, Lothar; Hall, Per; Hamann, Ute; Hankinson, Susan; Hartikainen, Jaana M; Hein, Alexander; Hiller, Louise; Hogervorst, Frans B; Holleczek, Bernd; Hooning, Maartje J; Hoover, Robert N; Humphreys, Keith; Hunter, David J; Hüsing, Anika; Jakubowska, Anna; Jukkola-Vuorinen, Arja; Kaaks, Rudolf; Kabisch, Maria; Kataja, Vesa; kConFab/AOCS Investigators; Knight, Julia A; Koppert, Linetta B; Kosma, Veli-Matti; Kristensen, Vessela N; Lambrechts, Diether; Marchand, Loic Le; Li, Jingmei; Lindblom, Annika; Lindström, Sara; Lissowska, Jolanta; Lubinski, Jan; Machiela, Mitchell J; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Marme, Federik; Martens, John WM; McLean, Catriona; Menéndez, Primitiva; Milne, Roger L; Mulligan, Anna Marie; Muranen, Taru A; Nevanlinna, Heli; Neven, Patrick; Nielsen, Sune F; Nordestgaard, Børge G; Olson, Janet E; Perez, Jose IA; Peterlongo, Paolo; Phillips, Kelly-Anne; Poole, Christopher J; Pylkäs, Katri; Radice, Paolo; Rahman, Nazneen; Rüdiger, Thomas; Rudolph, Anja; Sawyer, Elinor J; Schumacher, Fredrick; Seibold, Petra; Seynaeve, Caroline; Shah, Mitul; Smeets, Ann; Southey, Melissa C; Tollenaar, Rob A E M; Tomlinson, Ian; Tsimiklis, Helen; Ulmer, Hans Ulrich; Vachon, Celine; van den Ouweland, Ans MW; Van't Veer, Laura J; Wildiers, Hans; Willett, Walter; Winqvist, Robert; Pilar Zamora, M; Chenevix-Trench, Georgia; Dörk, Thilo; Easton, Douglas F.; García-Closas, Montserrat; Kraft, Peter; Hopper, John L; Zheng, Wei; Schmidt, Marjanka K; Pharoah, Paul DP.
In:
International Journal of Epidemiology, Vol. 46, No. 6, 2017, p. 1814-1822.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Guo, Q, Burgess, S, Turman, C, Bolla, MK, Wang, Q, Lush, M, Abraham, J, Aittomäki, K, Andrulis, IL, Apicella, C, Arndt, V, Barrdahl, M, Benitez, J, Berg, CD, Blomqvist, C
, Bojesen, SE, Bonanni, B, Brand, JS, Brenner, H, Broeks, A, Burwinkel, B, Caldas, C, Campa, D, Canzian, F, Chang-Claude, J, Chanock, SJ, Chin, S-F, Couch, FJ, Cox, A, Cross, SS, Cybulski, C, Czene, K, Darabi, H, Devilee, P, Diver, WR, Dunning, AM, Earl, HM, Eccles, DM, Ekici, AB, Eriksson, M, Evans, DG, Fasching, PA, Figueroa, J, Flesch-Janys, D, Flyger, H, Gapstur, SM, Gaudet, MM, Giles, GG, Glendon, G, Grip, M, Gronwald, J, Haeberle, L, Hall, P, Hamann, U, Hankinson, S, Hartikainen, JM, Hein, A, Hiller, L, Hogervorst, FB, Holleczek, B, Hooning, MJ, Hoover, RN, Humphreys, K, Hunter, DJ, Hüsing, A, Jakubowska, A, Jukkola-Vuorinen, A, Kaaks, R, Kabisch, M, Kataja, V, kConFab/AOCS Investigators, Knight, JA, Koppert, LB, Kosma, V-M, Kristensen, VN, Lambrechts, D, Marchand, LL, Li, J, Lindblom, A, Lindström, S, Lissowska, J, Lubinski, J, Machiela, MJ, Mannermaa, A, Manoukian, S, Margolin, S, Marme, F, Martens, JWM, McLean, C, Menéndez, P, Milne, RL, Mulligan, AM, Muranen, TA, Nevanlinna, H, Neven, P, Nielsen, SF
, Nordestgaard, BG, Olson, JE, Perez, JIA, Peterlongo, P, Phillips, K-A, Poole, CJ, Pylkäs, K, Radice, P, Rahman, N, Rüdiger, T, Rudolph, A, Sawyer, EJ, Schumacher, F, Seibold, P, Seynaeve, C, Shah, M, Smeets, A, Southey, MC, Tollenaar, RAEM, Tomlinson, I, Tsimiklis, H, Ulmer, HU, Vachon, C, van den Ouweland, AMW, Van't Veer, LJ, Wildiers, H, Willett, W, Winqvist, R, Pilar Zamora, M, Chenevix-Trench, G, Dörk, T, Easton, DF, García-Closas, M, Kraft, P, Hopper, JL, Zheng, W, Schmidt, MK & Pharoah, PDP 2017, '
Body mass index and breast cancer survival: a Mendelian randomization analysis',
International Journal of Epidemiology, vol. 46, no. 6, pp. 1814-1822.
https://doi.org/10.1093/ije/dyx131APA
Guo, Q., Burgess, S., Turman, C., Bolla, M. K., Wang, Q., Lush, M., Abraham, J., Aittomäki, K., Andrulis, I. L., Apicella, C., Arndt, V., Barrdahl, M., Benitez, J., Berg, C. D., Blomqvist, C.
, Bojesen, S. E., Bonanni, B., Brand, J. S., Brenner, H., ... Pharoah, P. DP. (2017).
Body mass index and breast cancer survival: a Mendelian randomization analysis.
International Journal of Epidemiology,
46(6), 1814-1822.
https://doi.org/10.1093/ije/dyx131Vancouver
Guo Q, Burgess S, Turman C, Bolla MK, Wang Q, Lush M et al.
Body mass index and breast cancer survival: a Mendelian randomization analysis.
International Journal of Epidemiology. 2017;46(6):1814-1822.
https://doi.org/10.1093/ije/dyx131Author
Guo, Qi ; Burgess, Stephen ; Turman, Constance ; Bolla, Manjeet K ; Wang, Qin ; Lush, Michael ; Abraham, Jean ; Aittomäki, Kristiina ; Andrulis, Irene L ; Apicella, Carmel ; Arndt, Volker ; Barrdahl, Myrto ; Benitez, Javier ; Berg, Christine D ; Blomqvist, Carl ; Bojesen, Stig E ; Bonanni, Bernardo ; Brand, Judith S ; Brenner, Hermann ; Broeks, Annegien ; Burwinkel, Barbara ; Caldas, Carlos ; Campa, Daniele ; Canzian, Federico ; Chang-Claude, Jenny ; Chanock, Stephen J ; Chin, Suet-Feung ; Couch, Fergus J ; Cox, Angela ; Cross, Simon S ; Cybulski, Cezary ; Czene, Kamila ; Darabi, Hatef ; Devilee, Peter ; Diver, W Ryan ; Dunning, Alison M ; Earl, Helena M ; Eccles, Diana M ; Ekici, Arif B ; Eriksson, Mikael ; Evans, D Gareth ; Fasching, Peter A ; Figueroa, Jonine ; Flesch-Janys, Dieter ; Flyger, Henrik ; Gapstur, Susan M ; Gaudet, Mia M ; Giles, Graham G ; Glendon, Gord ; Grip, Mervi ; Gronwald, Jacek ; Haeberle, Lothar ; Hall, Per ; Hamann, Ute ; Hankinson, Susan ; Hartikainen, Jaana M ; Hein, Alexander ; Hiller, Louise ; Hogervorst, Frans B ; Holleczek, Bernd ; Hooning, Maartje J ; Hoover, Robert N ; Humphreys, Keith ; Hunter, David J ; Hüsing, Anika ; Jakubowska, Anna ; Jukkola-Vuorinen, Arja ; Kaaks, Rudolf ; Kabisch, Maria ; Kataja, Vesa ; kConFab/AOCS Investigators ; Knight, Julia A ; Koppert, Linetta B ; Kosma, Veli-Matti ; Kristensen, Vessela N ; Lambrechts, Diether ; Marchand, Loic Le ; Li, Jingmei ; Lindblom, Annika ; Lindström, Sara ; Lissowska, Jolanta ; Lubinski, Jan ; Machiela, Mitchell J ; Mannermaa, Arto ; Manoukian, Siranoush ; Margolin, Sara ; Marme, Federik ; Martens, John WM ; McLean, Catriona ; Menéndez, Primitiva ; Milne, Roger L ; Mulligan, Anna Marie ; Muranen, Taru A ; Nevanlinna, Heli ; Neven, Patrick ; Nielsen, Sune F ; Nordestgaard, Børge G ; Olson, Janet E ; Perez, Jose IA ; Peterlongo, Paolo ; Phillips, Kelly-Anne ; Poole, Christopher J ; Pylkäs, Katri ; Radice, Paolo ; Rahman, Nazneen ; Rüdiger, Thomas ; Rudolph, Anja ; Sawyer, Elinor J ; Schumacher, Fredrick ; Seibold, Petra ; Seynaeve, Caroline ; Shah, Mitul ; Smeets, Ann ; Southey, Melissa C ; Tollenaar, Rob A E M ; Tomlinson, Ian ; Tsimiklis, Helen ; Ulmer, Hans Ulrich ; Vachon, Celine ; van den Ouweland, Ans MW ; Van't Veer, Laura J ; Wildiers, Hans ; Willett, Walter ; Winqvist, Robert ; Pilar Zamora, M ; Chenevix-Trench, Georgia ; Dörk, Thilo ; Easton, Douglas F. ; García-Closas, Montserrat ; Kraft, Peter ; Hopper, John L ; Zheng, Wei ; Schmidt, Marjanka K ; Pharoah, Paul DP. / Body mass index and breast cancer survival : a Mendelian randomization analysis. In: International Journal of Epidemiology. 2017 ; Vol. 46, No. 6. pp. 1814-1822.
Bibtex
@article{5e460eae12bb4769a4fa9e7756e4dd0b,
title = "Body mass index and breast cancer survival: a Mendelian randomization analysis",
abstract = "Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer.Methods: We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis.Results: BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01-1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89-1.13, P = 0.95).Conclusions: Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.",
author = "Qi Guo and Stephen Burgess and Constance Turman and Bolla, {Manjeet K} and Qin Wang and Michael Lush and Jean Abraham and Kristiina Aittom{\"a}ki and Andrulis, {Irene L} and Carmel Apicella and Volker Arndt and Myrto Barrdahl and Javier Benitez and Berg, {Christine D} and Carl Blomqvist and Bojesen, {Stig E} and Bernardo Bonanni and Brand, {Judith S} and Hermann Brenner and Annegien Broeks and Barbara Burwinkel and Carlos Caldas and Daniele Campa and Federico Canzian and Jenny Chang-Claude and Chanock, {Stephen J} and Suet-Feung Chin and Couch, {Fergus J} and Angela Cox and Cross, {Simon S} and Cezary Cybulski and Kamila Czene and Hatef Darabi and Peter Devilee and Diver, {W Ryan} and Dunning, {Alison M} and Earl, {Helena M} and Eccles, {Diana M} and Ekici, {Arif B} and Mikael Eriksson and Evans, {D Gareth} and Fasching, {Peter A} and Jonine Figueroa and Dieter Flesch-Janys and Henrik Flyger and Gapstur, {Susan M} and Gaudet, {Mia M} and Giles, {Graham G} and Gord Glendon and Mervi Grip and Jacek Gronwald and Lothar Haeberle and Per Hall and Ute Hamann and Susan Hankinson and Hartikainen, {Jaana M} and Alexander Hein and Louise Hiller and Hogervorst, {Frans B} and Bernd Holleczek and Hooning, {Maartje J} and Hoover, {Robert N} and Keith Humphreys and Hunter, {David J} and Anika H{\"u}sing and Anna Jakubowska and Arja Jukkola-Vuorinen and Rudolf Kaaks and Maria Kabisch and Vesa Kataja and {kConFab/AOCS Investigators} and Knight, {Julia A} and Koppert, {Linetta B} and Veli-Matti Kosma and Kristensen, {Vessela N} and Diether Lambrechts and Marchand, {Loic Le} and Jingmei Li and Annika Lindblom and Sara Lindstr{\"o}m and Jolanta Lissowska and Jan Lubinski and Machiela, {Mitchell J} and Arto Mannermaa and Siranoush Manoukian and Sara Margolin and Federik Marme and Martens, {John WM} and Catriona McLean and Primitiva Men{\'e}ndez and Milne, {Roger L} and Mulligan, {Anna Marie} and Muranen, {Taru A} and Heli Nevanlinna and Patrick Neven and Nielsen, {Sune F} and Nordestgaard, {B{\o}rge G} and Olson, {Janet E} and Perez, {Jose IA} and Paolo Peterlongo and Kelly-Anne Phillips and Poole, {Christopher J} and Katri Pylk{\"a}s and Paolo Radice and Nazneen Rahman and Thomas R{\"u}diger and Anja Rudolph and Sawyer, {Elinor J} and Fredrick Schumacher and Petra Seibold and Caroline Seynaeve and Mitul Shah and Ann Smeets and Southey, {Melissa C} and Tollenaar, {Rob A E M} and Ian Tomlinson and Helen Tsimiklis and Ulmer, {Hans Ulrich} and Celine Vachon and {van den Ouweland}, {Ans MW} and {Van't Veer}, {Laura J} and Hans Wildiers and Walter Willett and Robert Winqvist and {Pilar Zamora}, M and Georgia Chenevix-Trench and Thilo D{\"o}rk and Easton, {Douglas F.} and Montserrat Garc{\'i}a-Closas and Peter Kraft and Hopper, {John L} and Wei Zheng and Schmidt, {Marjanka K} and Pharoah, {Paul DP}",
note = "{\textcopyright} The Author 2017. Published by Oxford University Press on behalf of the International Epidemiological Association",
year = "2017",
doi = "10.1093/ije/dyx131",
language = "English",
volume = "46",
pages = "1814--1822",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "6",
}
RIS
TY - JOUR
T1 - Body mass index and breast cancer survival
T2 - a Mendelian randomization analysis
AU - Guo, Qi
AU - Burgess, Stephen
AU - Turman, Constance
AU - Bolla, Manjeet K
AU - Wang, Qin
AU - Lush, Michael
AU - Abraham, Jean
AU - Aittomäki, Kristiina
AU - Andrulis, Irene L
AU - Apicella, Carmel
AU - Arndt, Volker
AU - Barrdahl, Myrto
AU - Benitez, Javier
AU - Berg, Christine D
AU - Blomqvist, Carl
AU - Bojesen, Stig E
AU - Bonanni, Bernardo
AU - Brand, Judith S
AU - Brenner, Hermann
AU - Broeks, Annegien
AU - Burwinkel, Barbara
AU - Caldas, Carlos
AU - Campa, Daniele
AU - Canzian, Federico
AU - Chang-Claude, Jenny
AU - Chanock, Stephen J
AU - Chin, Suet-Feung
AU - Couch, Fergus J
AU - Cox, Angela
AU - Cross, Simon S
AU - Cybulski, Cezary
AU - Czene, Kamila
AU - Darabi, Hatef
AU - Devilee, Peter
AU - Diver, W Ryan
AU - Dunning, Alison M
AU - Earl, Helena M
AU - Eccles, Diana M
AU - Ekici, Arif B
AU - Eriksson, Mikael
AU - Evans, D Gareth
AU - Fasching, Peter A
AU - Figueroa, Jonine
AU - Flesch-Janys, Dieter
AU - Flyger, Henrik
AU - Gapstur, Susan M
AU - Gaudet, Mia M
AU - Giles, Graham G
AU - Glendon, Gord
AU - Grip, Mervi
AU - Gronwald, Jacek
AU - Haeberle, Lothar
AU - Hall, Per
AU - Hamann, Ute
AU - Hankinson, Susan
AU - Hartikainen, Jaana M
AU - Hein, Alexander
AU - Hiller, Louise
AU - Hogervorst, Frans B
AU - Holleczek, Bernd
AU - Hooning, Maartje J
AU - Hoover, Robert N
AU - Humphreys, Keith
AU - Hunter, David J
AU - Hüsing, Anika
AU - Jakubowska, Anna
AU - Jukkola-Vuorinen, Arja
AU - Kaaks, Rudolf
AU - Kabisch, Maria
AU - Kataja, Vesa
AU - kConFab/AOCS Investigators
AU - Knight, Julia A
AU - Koppert, Linetta B
AU - Kosma, Veli-Matti
AU - Kristensen, Vessela N
AU - Lambrechts, Diether
AU - Marchand, Loic Le
AU - Li, Jingmei
AU - Lindblom, Annika
AU - Lindström, Sara
AU - Lissowska, Jolanta
AU - Lubinski, Jan
AU - Machiela, Mitchell J
AU - Mannermaa, Arto
AU - Manoukian, Siranoush
AU - Margolin, Sara
AU - Marme, Federik
AU - Martens, John WM
AU - McLean, Catriona
AU - Menéndez, Primitiva
AU - Milne, Roger L
AU - Mulligan, Anna Marie
AU - Muranen, Taru A
AU - Nevanlinna, Heli
AU - Neven, Patrick
AU - Nielsen, Sune F
AU - Nordestgaard, Børge G
AU - Olson, Janet E
AU - Perez, Jose IA
AU - Peterlongo, Paolo
AU - Phillips, Kelly-Anne
AU - Poole, Christopher J
AU - Pylkäs, Katri
AU - Radice, Paolo
AU - Rahman, Nazneen
AU - Rüdiger, Thomas
AU - Rudolph, Anja
AU - Sawyer, Elinor J
AU - Schumacher, Fredrick
AU - Seibold, Petra
AU - Seynaeve, Caroline
AU - Shah, Mitul
AU - Smeets, Ann
AU - Southey, Melissa C
AU - Tollenaar, Rob A E M
AU - Tomlinson, Ian
AU - Tsimiklis, Helen
AU - Ulmer, Hans Ulrich
AU - Vachon, Celine
AU - van den Ouweland, Ans MW
AU - Van't Veer, Laura J
AU - Wildiers, Hans
AU - Willett, Walter
AU - Winqvist, Robert
AU - Pilar Zamora, M
AU - Chenevix-Trench, Georgia
AU - Dörk, Thilo
AU - Easton, Douglas F.
AU - García-Closas, Montserrat
AU - Kraft, Peter
AU - Hopper, John L
AU - Zheng, Wei
AU - Schmidt, Marjanka K
AU - Pharoah, Paul DP
N1 - © The Author 2017. Published by Oxford University Press on behalf of the International Epidemiological Association
PY - 2017
Y1 - 2017
N2 - Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer.Methods: We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis.Results: BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01-1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89-1.13, P = 0.95).Conclusions: Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.
AB - Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer.Methods: We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis.Results: BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01-1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89-1.13, P = 0.95).Conclusions: Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.
U2 - 10.1093/ije/dyx131
DO - 10.1093/ije/dyx131
M3 - Journal article
C2 - 29232439
VL - 46
SP - 1814
EP - 1822
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
SN - 0300-5771
IS - 6
ER -
