Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets. / Jensen, Michael Ladegaard; Thymann, Thomas; Cilieborg, Malene Skovsted; Jensen, Mikkel Lykke; Mølbak, Lars; Jensen, Bent B; Schmidt, Mette; Kelly, Denise; Mulder, Imke; Burrin, Douglas G; Sangild, Per Torp.

In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 306, No. 1, 2014, p. G59-G71.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, ML, Thymann, T, Cilieborg, MS, Jensen, ML, Mølbak, L, Jensen, BB, Schmidt, M, Kelly, D, Mulder, I, Burrin, DG & Sangild, PT 2014, 'Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 306, no. 1, pp. G59-G71. https://doi.org/10.1152/ajpgi.00213.2013

APA

Jensen, M. L., Thymann, T., Cilieborg, M. S., Jensen, M. L., Mølbak, L., Jensen, B. B., Schmidt, M., Kelly, D., Mulder, I., Burrin, D. G., & Sangild, P. T. (2014). Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets. American Journal of Physiology: Gastrointestinal and Liver Physiology, 306(1), G59-G71. https://doi.org/10.1152/ajpgi.00213.2013

Vancouver

Jensen ML, Thymann T, Cilieborg MS, Jensen ML, Mølbak L, Jensen BB et al. Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2014;306(1):G59-G71. https://doi.org/10.1152/ajpgi.00213.2013

Author

Jensen, Michael Ladegaard ; Thymann, Thomas ; Cilieborg, Malene Skovsted ; Jensen, Mikkel Lykke ; Mølbak, Lars ; Jensen, Bent B ; Schmidt, Mette ; Kelly, Denise ; Mulder, Imke ; Burrin, Douglas G ; Sangild, Per Torp. / Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets. In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 2014 ; Vol. 306, No. 1. pp. G59-G71.

Bibtex

@article{6c7401ef351f431b8c54336876e4fdb6,
title = "Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets",
abstract = "Preterm birth, bacterial colonization and formula feeding predispose to necrotizing enterocolitis (NEC). Antibiotics are commonly administered to prevent sepsis in preterm infants, but it is not known whether this affects intestinal immunity and NEC resistance. We hypothesized that broad-spectrum antibiotics treatment improves NEC resistance and intestinal structure, function and immunity in neonates. Caesarean-delivered preterm pigs were fed 3 d of parenteral nutrition followed by 2 d of enteral formula. Immediately after birth they were assigned to receive either antibiotics (oral and parenteral doses of gentamycin, ampicillin and metronidazole, ANTI, n=11) or saline in the control group (CON, n=13), given twice daily. NEC-lesions and intestinal structure, function, microbiology and immunity markers were recorded. None of the ANTI but 85% of the CON pigs developed NEC lesions by d 5 (0/11 vs. 11/13, P",
author = "Jensen, {Michael Ladegaard} and Thomas Thymann and Cilieborg, {Malene Skovsted} and Jensen, {Mikkel Lykke} and Lars M{\o}lbak and Jensen, {Bent B} and Mette Schmidt and Denise Kelly and Imke Mulder and Burrin, {Douglas G} and Sangild, {Per Torp}",
note = "CURIS 2014 NEXS 003",
year = "2014",
doi = "10.1152/ajpgi.00213.2013",
language = "English",
volume = "306",
pages = "G59--G71",
journal = "American Journal of Physiology: Gastrointestinal and Liver Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets

AU - Jensen, Michael Ladegaard

AU - Thymann, Thomas

AU - Cilieborg, Malene Skovsted

AU - Jensen, Mikkel Lykke

AU - Mølbak, Lars

AU - Jensen, Bent B

AU - Schmidt, Mette

AU - Kelly, Denise

AU - Mulder, Imke

AU - Burrin, Douglas G

AU - Sangild, Per Torp

N1 - CURIS 2014 NEXS 003

PY - 2014

Y1 - 2014

N2 - Preterm birth, bacterial colonization and formula feeding predispose to necrotizing enterocolitis (NEC). Antibiotics are commonly administered to prevent sepsis in preterm infants, but it is not known whether this affects intestinal immunity and NEC resistance. We hypothesized that broad-spectrum antibiotics treatment improves NEC resistance and intestinal structure, function and immunity in neonates. Caesarean-delivered preterm pigs were fed 3 d of parenteral nutrition followed by 2 d of enteral formula. Immediately after birth they were assigned to receive either antibiotics (oral and parenteral doses of gentamycin, ampicillin and metronidazole, ANTI, n=11) or saline in the control group (CON, n=13), given twice daily. NEC-lesions and intestinal structure, function, microbiology and immunity markers were recorded. None of the ANTI but 85% of the CON pigs developed NEC lesions by d 5 (0/11 vs. 11/13, P

AB - Preterm birth, bacterial colonization and formula feeding predispose to necrotizing enterocolitis (NEC). Antibiotics are commonly administered to prevent sepsis in preterm infants, but it is not known whether this affects intestinal immunity and NEC resistance. We hypothesized that broad-spectrum antibiotics treatment improves NEC resistance and intestinal structure, function and immunity in neonates. Caesarean-delivered preterm pigs were fed 3 d of parenteral nutrition followed by 2 d of enteral formula. Immediately after birth they were assigned to receive either antibiotics (oral and parenteral doses of gentamycin, ampicillin and metronidazole, ANTI, n=11) or saline in the control group (CON, n=13), given twice daily. NEC-lesions and intestinal structure, function, microbiology and immunity markers were recorded. None of the ANTI but 85% of the CON pigs developed NEC lesions by d 5 (0/11 vs. 11/13, P

U2 - 10.1152/ajpgi.00213.2013

DO - 10.1152/ajpgi.00213.2013

M3 - Journal article

C2 - 24157972

VL - 306

SP - G59-G71

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

SN - 0193-1857

IS - 1

ER -

ID: 91314576