Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers

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Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers. / Schmidt, Marjanka K; Hogervorst, Frans; van Hien, Richard R; Cornelissen, Sten; Broeks, Annegien; Adank, Muriel A; Meijers-Heijboer, Hanne; Waisfisz, Quinten; Hollestelle, Antoinette; Schutte, Mieke; van den Ouweland, Ans; Hooning, Maartje; Andrulis, Irene L; Anton-Culver, Hoda; Antonenkova, Natalia; Antoniou, Antonis C; Arndt, Volker; Bermisheva, Marina; Bogdanova, Natalia V; Bolla, Manjeet K; Brauch, Hiltrud; Brenner, Hermann; Brüning, Thomas; Burwinkel, Barbara; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Dunning, Alison M; Fasching, Peter A; Figueroa, Jonine; Fletcher, Olivia; Flyger, Henrik; Galle, Eva; García-Closas, Montserrat; Giles, Graham; Haeberle, Lothar; Hall, Per; Hillemanns, Peter; Hopper, John L; Jakubowska, Anna; John, Esther M; Jones, Michael; Khusnutdinova, Elza; Knight, Julia A; Kosma, Veli-Matti; Kristensen, Vessela; Lee, Andrew; Lindblom, Annika; Lubinski, Jan; Mannermaa, Arto; Margolin, Sara; Meindl, Alfons; Milne, Roger L; Muranen, Taru A; Newcomb, Polly A; Offit, Kenneth; Park-Simon, Tjoung-Won; Peto, Julian; Pharoah, Paul P D; Robson, Mark; Rudolph, Anja; Sawyer, Elinor J; Schmutzler, Rita K; Seynaeve, Caroline; Soens, Julie; Southey, Melissa C; Spurdle, Amanda B; Surowy, Harald M; Swerdlow, Anthony; Tollenaar, Rob A E M; Tomlinson, Ian; Trentham-Dietz, Amy; Vachon, Celine; Wang, Qin; Whittemore, Alice S; Ziogas, Argyrios; van der Kolk, Lizet; Nevanlinna, Heli; Doerk, Thilo; Bojesen, Stig; Easton, Douglas F.

In: Journal of Clinical Oncology, Vol. 34, No. 23, 10.08.2016, p. 2750-60.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schmidt, MK, Hogervorst, F, van Hien, RR, Cornelissen, S, Broeks, A, Adank, MA, Meijers-Heijboer, H, Waisfisz, Q, Hollestelle, A, Schutte, M, van den Ouweland, A, Hooning, M, Andrulis, IL, Anton-Culver, H, Antonenkova, N, Antoniou, AC, Arndt, V, Bermisheva, M, Bogdanova, NV, Bolla, MK, Brauch, H, Brenner, H, Brüning, T, Burwinkel, B, Chang-Claude, J, Chenevix-Trench, G, Couch, FJ, Cox, A, Cross, SS, Czene, K, Dunning, AM, Fasching, PA, Figueroa, J, Fletcher, O, Flyger, H, Galle, E, García-Closas, M, Giles, G, Haeberle, L, Hall, P, Hillemanns, P, Hopper, JL, Jakubowska, A, John, EM, Jones, M, Khusnutdinova, E, Knight, JA, Kosma, V-M, Kristensen, V, Lee, A, Lindblom, A, Lubinski, J, Mannermaa, A, Margolin, S, Meindl, A, Milne, RL, Muranen, TA, Newcomb, PA, Offit, K, Park-Simon, T-W, Peto, J, Pharoah, PPD, Robson, M, Rudolph, A, Sawyer, EJ, Schmutzler, RK, Seynaeve, C, Soens, J, Southey, MC, Spurdle, AB, Surowy, HM, Swerdlow, A, Tollenaar, RAEM, Tomlinson, I, Trentham-Dietz, A, Vachon, C, Wang, Q, Whittemore, AS, Ziogas, A, van der Kolk, L, Nevanlinna, H, Doerk, T, Bojesen, S & Easton, DF 2016, 'Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers', Journal of Clinical Oncology, vol. 34, no. 23, pp. 2750-60. https://doi.org/10.1200/JCO.2016.66.5844

APA

Schmidt, M. K., Hogervorst, F., van Hien, R. R., Cornelissen, S., Broeks, A., Adank, M. A., Meijers-Heijboer, H., Waisfisz, Q., Hollestelle, A., Schutte, M., van den Ouweland, A., Hooning, M., Andrulis, I. L., Anton-Culver, H., Antonenkova, N., Antoniou, A. C., Arndt, V., Bermisheva, M., Bogdanova, N. V., ... Easton, D. F. (2016). Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers. Journal of Clinical Oncology, 34(23), 2750-60. https://doi.org/10.1200/JCO.2016.66.5844

Vancouver

Schmidt MK, Hogervorst F, van Hien RR, Cornelissen S, Broeks A, Adank MA et al. Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers. Journal of Clinical Oncology. 2016 Aug 10;34(23):2750-60. https://doi.org/10.1200/JCO.2016.66.5844

Author

Schmidt, Marjanka K ; Hogervorst, Frans ; van Hien, Richard R ; Cornelissen, Sten ; Broeks, Annegien ; Adank, Muriel A ; Meijers-Heijboer, Hanne ; Waisfisz, Quinten ; Hollestelle, Antoinette ; Schutte, Mieke ; van den Ouweland, Ans ; Hooning, Maartje ; Andrulis, Irene L ; Anton-Culver, Hoda ; Antonenkova, Natalia ; Antoniou, Antonis C ; Arndt, Volker ; Bermisheva, Marina ; Bogdanova, Natalia V ; Bolla, Manjeet K ; Brauch, Hiltrud ; Brenner, Hermann ; Brüning, Thomas ; Burwinkel, Barbara ; Chang-Claude, Jenny ; Chenevix-Trench, Georgia ; Couch, Fergus J ; Cox, Angela ; Cross, Simon S ; Czene, Kamila ; Dunning, Alison M ; Fasching, Peter A ; Figueroa, Jonine ; Fletcher, Olivia ; Flyger, Henrik ; Galle, Eva ; García-Closas, Montserrat ; Giles, Graham ; Haeberle, Lothar ; Hall, Per ; Hillemanns, Peter ; Hopper, John L ; Jakubowska, Anna ; John, Esther M ; Jones, Michael ; Khusnutdinova, Elza ; Knight, Julia A ; Kosma, Veli-Matti ; Kristensen, Vessela ; Lee, Andrew ; Lindblom, Annika ; Lubinski, Jan ; Mannermaa, Arto ; Margolin, Sara ; Meindl, Alfons ; Milne, Roger L ; Muranen, Taru A ; Newcomb, Polly A ; Offit, Kenneth ; Park-Simon, Tjoung-Won ; Peto, Julian ; Pharoah, Paul P D ; Robson, Mark ; Rudolph, Anja ; Sawyer, Elinor J ; Schmutzler, Rita K ; Seynaeve, Caroline ; Soens, Julie ; Southey, Melissa C ; Spurdle, Amanda B ; Surowy, Harald M ; Swerdlow, Anthony ; Tollenaar, Rob A E M ; Tomlinson, Ian ; Trentham-Dietz, Amy ; Vachon, Celine ; Wang, Qin ; Whittemore, Alice S ; Ziogas, Argyrios ; van der Kolk, Lizet ; Nevanlinna, Heli ; Doerk, Thilo ; Bojesen, Stig ; Easton, Douglas F. / Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers. In: Journal of Clinical Oncology. 2016 ; Vol. 34, No. 23. pp. 2750-60.

Bibtex

@article{18446b0ef960478192e9950cad32f7e2,

title = "Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers",

abstract = "PURPOSE: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC.PATIENTS AND METHODS: CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (ORs) for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression and adjusted for study (categorical) and age. Main analyses included patients with invasive breast cancer from population- and hospital-based studies.RESULTS: Proportions of heterozygous CHEK2*1100delC carriers in controls, in patients with breast cancer from population- and hospital-based studies, and in patients with breast cancer from familial- and clinical genetics center-based studies were 0.5%, 1.3%, and 3.0%, respectively. The estimated OR for invasive breast cancer was 2.26 (95%CI, 1.90 to 2.69; P = 2.3 × 10(-20)). The OR was higher for estrogen receptor (ER)-positive disease (2.55 [95%CI, 2.10 to 3.10; P = 4.9 × 10(-21)]) than it was for ER-negative disease (1.32 [95%CI, 0.93 to 1.88; P = .12]; P interaction = 9.9 × 10(-4)). The OR significantly declined with attained age for breast cancer overall (P = .001) and for ER-positive tumors (P = .001). Estimated cumulative risks for development of ER-positive and ER-negative tumors by age 80 in CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom.CONCLUSION: These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models and into guidelines for intensified screening and follow-up.",

keywords = "Journal Article",

author = "Schmidt, {Marjanka K} and Frans Hogervorst and {van Hien}, {Richard R} and Sten Cornelissen and Annegien Broeks and Adank, {Muriel A} and Hanne Meijers-Heijboer and Quinten Waisfisz and Antoinette Hollestelle and Mieke Schutte and {van den Ouweland}, Ans and Maartje Hooning and Andrulis, {Irene L} and Hoda Anton-Culver and Natalia Antonenkova and Antoniou, {Antonis C} and Volker Arndt and Marina Bermisheva and Bogdanova, {Natalia V} and Bolla, {Manjeet K} and Hiltrud Brauch and Hermann Brenner and Thomas Br{\"u}ning and Barbara Burwinkel and Jenny Chang-Claude and Georgia Chenevix-Trench and Couch, {Fergus J} and Angela Cox and Cross, {Simon S} and Kamila Czene and Dunning, {Alison M} and Fasching, {Peter A} and Jonine Figueroa and Olivia Fletcher and Henrik Flyger and Eva Galle and Montserrat Garc{\'i}a-Closas and Graham Giles and Lothar Haeberle and Per Hall and Peter Hillemanns and Hopper, {John L} and Anna Jakubowska and John, {Esther M} and Michael Jones and Elza Khusnutdinova and Knight, {Julia A} and Veli-Matti Kosma and Vessela Kristensen and Andrew Lee and Annika Lindblom and Jan Lubinski and Arto Mannermaa and Sara Margolin and Alfons Meindl and Milne, {Roger L} and Muranen, {Taru A} and Newcomb, {Polly A} and Kenneth Offit and Tjoung-Won Park-Simon and Julian Peto and Pharoah, {Paul P D} and Mark Robson and Anja Rudolph and Sawyer, {Elinor J} and Schmutzler, {Rita K} and Caroline Seynaeve and Julie Soens and Southey, {Melissa C} and Spurdle, {Amanda B} and Surowy, {Harald M} and Anthony Swerdlow and Tollenaar, {Rob A E M} and Ian Tomlinson and Amy Trentham-Dietz and Celine Vachon and Qin Wang and Whittemore, {Alice S} and Argyrios Ziogas and {van der Kolk}, Lizet and Heli Nevanlinna and Thilo Doerk and Stig Bojesen and Easton, {Douglas F}",

note = "{\textcopyright} 2016 by American Society of Clinical Oncology.",

year = "2016",

month = aug,

day = "10",

doi = "10.1200/JCO.2016.66.5844",

language = "English",

volume = "34",

pages = "2750--60",

journal = "Journal of Clinical Oncology",

issn = "0732-183X",

publisher = "American Society of Clinical Oncology",

number = "23",

}

RIS

TY - JOUR

T1 - Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers

AU - Schmidt, Marjanka K

AU - Hogervorst, Frans

AU - van Hien, Richard R

AU - Cornelissen, Sten

AU - Broeks, Annegien

AU - Adank, Muriel A

AU - Meijers-Heijboer, Hanne

AU - Waisfisz, Quinten

AU - Hollestelle, Antoinette

AU - Schutte, Mieke

AU - van den Ouweland, Ans

AU - Hooning, Maartje

AU - Andrulis, Irene L

AU - Anton-Culver, Hoda

AU - Antonenkova, Natalia

AU - Antoniou, Antonis C

AU - Arndt, Volker

AU - Bermisheva, Marina

AU - Bogdanova, Natalia V

AU - Bolla, Manjeet K

AU - Brauch, Hiltrud

AU - Brenner, Hermann

AU - Brüning, Thomas

AU - Burwinkel, Barbara

AU - Chang-Claude, Jenny

AU - Chenevix-Trench, Georgia

AU - Couch, Fergus J

AU - Cox, Angela

AU - Cross, Simon S

AU - Czene, Kamila

AU - Dunning, Alison M

AU - Fasching, Peter A

AU - Figueroa, Jonine

AU - Fletcher, Olivia

AU - Flyger, Henrik

AU - Galle, Eva

AU - García-Closas, Montserrat

AU - Giles, Graham

AU - Haeberle, Lothar

AU - Hall, Per

AU - Hillemanns, Peter

AU - Hopper, John L

AU - Jakubowska, Anna

AU - John, Esther M

AU - Jones, Michael

AU - Khusnutdinova, Elza

AU - Knight, Julia A

AU - Kosma, Veli-Matti

AU - Kristensen, Vessela

AU - Lee, Andrew

AU - Lindblom, Annika

AU - Lubinski, Jan

AU - Mannermaa, Arto

AU - Margolin, Sara

AU - Meindl, Alfons

AU - Milne, Roger L

AU - Muranen, Taru A

AU - Newcomb, Polly A

AU - Offit, Kenneth

AU - Park-Simon, Tjoung-Won

AU - Peto, Julian

AU - Pharoah, Paul P D

AU - Robson, Mark

AU - Rudolph, Anja

AU - Sawyer, Elinor J

AU - Schmutzler, Rita K

AU - Seynaeve, Caroline

AU - Soens, Julie

AU - Southey, Melissa C

AU - Spurdle, Amanda B

AU - Surowy, Harald M

AU - Swerdlow, Anthony

AU - Tollenaar, Rob A E M

AU - Tomlinson, Ian

AU - Trentham-Dietz, Amy

AU - Vachon, Celine

AU - Wang, Qin

AU - Whittemore, Alice S

AU - Ziogas, Argyrios

AU - van der Kolk, Lizet

AU - Nevanlinna, Heli

AU - Doerk, Thilo

AU - Bojesen, Stig

AU - Easton, Douglas F

PY - 2016/8/10

Y1 - 2016/8/10

N2 - PURPOSE: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC.PATIENTS AND METHODS: CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (ORs) for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression and adjusted for study (categorical) and age. Main analyses included patients with invasive breast cancer from population- and hospital-based studies.RESULTS: Proportions of heterozygous CHEK2*1100delC carriers in controls, in patients with breast cancer from population- and hospital-based studies, and in patients with breast cancer from familial- and clinical genetics center-based studies were 0.5%, 1.3%, and 3.0%, respectively. The estimated OR for invasive breast cancer was 2.26 (95%CI, 1.90 to 2.69; P = 2.3 × 10(-20)). The OR was higher for estrogen receptor (ER)-positive disease (2.55 [95%CI, 2.10 to 3.10; P = 4.9 × 10(-21)]) than it was for ER-negative disease (1.32 [95%CI, 0.93 to 1.88; P = .12]; P interaction = 9.9 × 10(-4)). The OR significantly declined with attained age for breast cancer overall (P = .001) and for ER-positive tumors (P = .001). Estimated cumulative risks for development of ER-positive and ER-negative tumors by age 80 in CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom.CONCLUSION: These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models and into guidelines for intensified screening and follow-up.

AB - PURPOSE: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC.PATIENTS AND METHODS: CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (ORs) for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression and adjusted for study (categorical) and age. Main analyses included patients with invasive breast cancer from population- and hospital-based studies.RESULTS: Proportions of heterozygous CHEK2*1100delC carriers in controls, in patients with breast cancer from population- and hospital-based studies, and in patients with breast cancer from familial- and clinical genetics center-based studies were 0.5%, 1.3%, and 3.0%, respectively. The estimated OR for invasive breast cancer was 2.26 (95%CI, 1.90 to 2.69; P = 2.3 × 10(-20)). The OR was higher for estrogen receptor (ER)-positive disease (2.55 [95%CI, 2.10 to 3.10; P = 4.9 × 10(-21)]) than it was for ER-negative disease (1.32 [95%CI, 0.93 to 1.88; P = .12]; P interaction = 9.9 × 10(-4)). The OR significantly declined with attained age for breast cancer overall (P = .001) and for ER-positive tumors (P = .001). Estimated cumulative risks for development of ER-positive and ER-negative tumors by age 80 in CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom.CONCLUSION: These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models and into guidelines for intensified screening and follow-up.

KW - Journal Article

U2 - 10.1200/JCO.2016.66.5844

DO - 10.1200/JCO.2016.66.5844

M3 - Journal article

C2 - 27269948

VL - 34

SP - 2750

EP - 2760

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 23

ER -

ID: 176955144