Adhesion, growth, and matrix production by fibroblasts on laminin substrates.

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Adhesion, growth, and matrix production by fibroblasts on laminin substrates. / Couchman, J R; Höök, M; Rees, D A; Timpl, R.

In: Journal of Cell Biology, Vol. 96, No. 1, 1983, p. 177-83.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Couchman, JR, Höök, M, Rees, DA & Timpl, R 1983, 'Adhesion, growth, and matrix production by fibroblasts on laminin substrates.', Journal of Cell Biology, vol. 96, no. 1, pp. 177-83.

APA

Couchman, J. R., Höök, M., Rees, D. A., & Timpl, R. (1983). Adhesion, growth, and matrix production by fibroblasts on laminin substrates. Journal of Cell Biology, 96(1), 177-83.

Vancouver

Couchman JR, Höök M, Rees DA, Timpl R. Adhesion, growth, and matrix production by fibroblasts on laminin substrates. Journal of Cell Biology. 1983;96(1):177-83.

Author

Couchman, J R ; Höök, M ; Rees, D A ; Timpl, R. / Adhesion, growth, and matrix production by fibroblasts on laminin substrates. In: Journal of Cell Biology. 1983 ; Vol. 96, No. 1. pp. 177-83.

Bibtex

@article{58154fd0598f11dd8d9f000ea68e967b,
title = "Adhesion, growth, and matrix production by fibroblasts on laminin substrates.",
abstract = "Human embryonic skin fibroblasts have been shown to attach and spread on laminin substrates in the absence of protein synthesis and presence of fibronectin-depleted serum and anti-fibronectin antibodies. Rates of attachment and the type of spreading are virtually identical on fibronectin and laminin-coated substrates with the development of microfilament bundles and focal adhesions. Antibodies to laminin, but not fibronectin, will prevent or reverse fibroblast adhesion to laminin, whereas antibodies to fibronectin but not laminin will give similar results on fibronectin-coated substrates. These and other results indicate that fibroblasts possess distinct receptors for laminin and fibronectin which on contact with suitable substrates promote adhesion through interaction with common intermediates. This type of adhesion is compatible with subsequent growth and extracellular matrix production.",
author = "Couchman, {J R} and M H{\"o}{\"o}k and Rees, {D A} and R Timpl",
note = "Keywords: Antibodies; Cell Adhesion; Cell Division; Cell Movement; Cells, Cultured; Cytoskeleton; Fibroblasts; Fibronectins; Glycoproteins; Humans; Laminin; Procollagen; Skin",
year = "1983",
language = "English",
volume = "96",
pages = "177--83",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Adhesion, growth, and matrix production by fibroblasts on laminin substrates.

AU - Couchman, J R

AU - Höök, M

AU - Rees, D A

AU - Timpl, R

N1 - Keywords: Antibodies; Cell Adhesion; Cell Division; Cell Movement; Cells, Cultured; Cytoskeleton; Fibroblasts; Fibronectins; Glycoproteins; Humans; Laminin; Procollagen; Skin

PY - 1983

Y1 - 1983

N2 - Human embryonic skin fibroblasts have been shown to attach and spread on laminin substrates in the absence of protein synthesis and presence of fibronectin-depleted serum and anti-fibronectin antibodies. Rates of attachment and the type of spreading are virtually identical on fibronectin and laminin-coated substrates with the development of microfilament bundles and focal adhesions. Antibodies to laminin, but not fibronectin, will prevent or reverse fibroblast adhesion to laminin, whereas antibodies to fibronectin but not laminin will give similar results on fibronectin-coated substrates. These and other results indicate that fibroblasts possess distinct receptors for laminin and fibronectin which on contact with suitable substrates promote adhesion through interaction with common intermediates. This type of adhesion is compatible with subsequent growth and extracellular matrix production.

AB - Human embryonic skin fibroblasts have been shown to attach and spread on laminin substrates in the absence of protein synthesis and presence of fibronectin-depleted serum and anti-fibronectin antibodies. Rates of attachment and the type of spreading are virtually identical on fibronectin and laminin-coated substrates with the development of microfilament bundles and focal adhesions. Antibodies to laminin, but not fibronectin, will prevent or reverse fibroblast adhesion to laminin, whereas antibodies to fibronectin but not laminin will give similar results on fibronectin-coated substrates. These and other results indicate that fibroblasts possess distinct receptors for laminin and fibronectin which on contact with suitable substrates promote adhesion through interaction with common intermediates. This type of adhesion is compatible with subsequent growth and extracellular matrix production.

M3 - Journal article

C2 - 6681817

VL - 96

SP - 177

EP - 183

JO - Journal of Cell Biology

JF - Journal of Cell Biology

SN - 0021-9525

IS - 1

ER -

ID: 5167837