Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection
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Human immunodeficiency virus-1 (HIV-1) infection has been shown to result in up-regulation of the urokinase-type plasminogen activator receptor (uPAR/CD87) on leukocytes in vitro and in vivo. The objective of this study was to investigate whether this up-regulation is paralleled by higher serum levels of soluble uPAR (suPAR) in patients with advanced HIV-1 disease and whether the serum level of suPAR is predictive of clinical outcome. Using an enzyme-linked immunosorbent assay, the level of suPAR was measured retrospectively in serum samples from 314 patients with HIV-1 infection. By Kaplan-Meier and Cox regression analyses, the serum suPAR levels were correlated to survival with AIDS-related death as the end point. High levels of serum suPAR (greater than median) were associated with poor overall survival, and Kaplan-Meier analysis on patients stratified by suPAR level demonstrated a continuous increase in mortality rates with higher suPAR levels. After adjustment for accepted prognostic markers-including Centers for Disease Control and Prevention-defined clinical stages, CD4 counts, viral load, beta2-microglobulin, and age-the prognostic strength of suPAR remained highly significant, indicating that the serum suPAR level is a novel, strong, and independent predictor of survival in HIV-1 infection. This report is the first to demonstrate an important association between the plasminogen activator system and disease progression in HIV-1 infection.
Original language | English |
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Journal | Blood |
Volume | 96 |
Issue number | 13 |
Pages (from-to) | 4091-5 |
Number of pages | 5 |
ISSN | 0006-4971 |
Publication status | Published - 15 Dec 2000 |
- Adolescent, Adult, Aged, Antiretroviral Therapy, Highly Active, Cohort Studies, Denmark, Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, HIV Infections, HIV-1, Humans, Life Tables, Male, Middle Aged, Prognosis, Proportional Hazards Models, Receptors, Cell Surface, Receptors, Urokinase Plasminogen Activator, Retrospective Studies, Severity of Illness Index, Solubility, Survival Analysis, Treatment Outcome, Journal Article
Research areas
ID: 180571657