Serum galectin-2, -4, and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium
Research output: Contribution to journal › Journal article › Research › peer-review
Adhesion of disseminating tumor cells to the blood vascular endothelium is a pivotal step in metastasis. Previous investigations have shown that galectin-3 concentrations are increased in the bloodstream of patients with cancer and that galectin-3 promotes adhesion of disseminating tumor cells to vascular endothelium in vitro and experimental metastasis in vivo. This study determined the levels of galectin-1, -2, -3, -4, -8, and -9 in the sera of healthy people and patients with colon and breast cancer and assessed the influence of these galectins on cancer-endothelium adhesion.
Original language | English |
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Journal | Clinical Cancer Research |
Volume | 17 |
Issue number | 22 |
Pages (from-to) | 7035-7046 |
Number of pages | 12 |
ISSN | 1078-0432 |
DOIs | |
Publication status | Published - 15 Nov 2011 |
ID: 37622261