Serum galectin-2, -4, and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium
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Serum galectin-2, -4, and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium. / Barrow, Hannah; Guo, Xiuli; Wandall, Hans H; Pedersen, Johannes W; Fu, Bo; Zhao, Qicheng; Chen, Chen; Rhodes, Jonathan M; Yu, Lu-Gang.
In: Clinical Cancer Research, Vol. 17, No. 22, 15.11.2011, p. 7035-7046.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Serum galectin-2, -4, and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium
AU - Barrow, Hannah
AU - Guo, Xiuli
AU - Wandall, Hans H
AU - Pedersen, Johannes W
AU - Fu, Bo
AU - Zhao, Qicheng
AU - Chen, Chen
AU - Rhodes, Jonathan M
AU - Yu, Lu-Gang
PY - 2011/11/15
Y1 - 2011/11/15
N2 - Adhesion of disseminating tumor cells to the blood vascular endothelium is a pivotal step in metastasis. Previous investigations have shown that galectin-3 concentrations are increased in the bloodstream of patients with cancer and that galectin-3 promotes adhesion of disseminating tumor cells to vascular endothelium in vitro and experimental metastasis in vivo. This study determined the levels of galectin-1, -2, -3, -4, -8, and -9 in the sera of healthy people and patients with colon and breast cancer and assessed the influence of these galectins on cancer-endothelium adhesion.
AB - Adhesion of disseminating tumor cells to the blood vascular endothelium is a pivotal step in metastasis. Previous investigations have shown that galectin-3 concentrations are increased in the bloodstream of patients with cancer and that galectin-3 promotes adhesion of disseminating tumor cells to vascular endothelium in vitro and experimental metastasis in vivo. This study determined the levels of galectin-1, -2, -3, -4, -8, and -9 in the sera of healthy people and patients with colon and breast cancer and assessed the influence of these galectins on cancer-endothelium adhesion.
U2 - 10.1158/1078-0432.CCR-11-1462
DO - 10.1158/1078-0432.CCR-11-1462
M3 - Journal article
C2 - 21933892
VL - 17
SP - 7035
EP - 7046
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 22
ER -
ID: 37622261