Effects of subcutaneous interleukin-2 therapy on phenotype and function of peripheral blood mononuclear cells in human immunodeficiency virus infected patients
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In the context of clinical therapy with recombinant human interleukin-2 (IL-2), we monitored immunological alteration in 10 human immunodeficiency virus type-I (HIV-1)-infected individuals, on stable antiretroviral therapy, who had a CD4+ cell count between 200 and 500 cells/mm3. Subcutaneous IL-2 was prescribed thrice weekly (at a dose of 3 x 10(6) IU) for 24 weeks and the patients were followed-up for 32 weeks. IL-2 treatment induced an increase in the CD4+ percentage (P<0.001) and CD4+ cell count (P<0.009). Furthermore. natural killer (NK) cell activity was increased (P<0.001) at week 8 of treatment, whereas lymphokine-activated killer (LAK) cell activity showed a transient, nonsignificant increase at week 8 and was reduced (P<0.001) at 32 weeks. However, the cytotoxic T-lymphocyte (CTL) activity decreased against HIV antigens, and the proliferative response to Candida, IL-2 and phytohaemagglutinin (PHA) declined during the first 8 weeks (P<0.05) and returned to baseline levels after 32 weeks. The HIV RNA level did not change during IL-2 therapy; however, after 8 weeks of follow-up a significant increase (P<0.001) in viral load was observed. In
Original language | English |
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Journal | Scandinavian Journal of Immunology |
Volume | 51 |
Issue number | 2 |
Pages (from-to) | 168-75 |
Number of pages | 8 |
ISSN | 0300-9475 |
Publication status | Published - Feb 2000 |
- Adult, Anti-HIV Agents, Cell Division, Follow-Up Studies, HIV Infections, HIV-1, Humans, Immunophenotyping, Injections, Subcutaneous, Interleukin-2, Killer Cells, Lymphokine-Activated, Killer Cells, Natural, Leukocytes, Mononuclear, Recombinant Proteins, T-Lymphocytes, Cytotoxic, Viral Load, Clinical Trial, Journal Article
Research areas
ID: 180571989