Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes
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Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes. / Bybjerg-Grauholm, Jonas; Hagen, Christian M.; Gonçalves, Vanessa F.; Bækvad-Hansen, Marie; Hansen, Christine S.; Hedley, Paula L.; Kanters, Jørgen K.; Nielsen, Jimmi; Theisen, Michael; Mors, Ole; Kennedy, James; Als, Thomas D.; Demur, Alfonso B.; Nordentoft, Merete; Børglum, Anders; Mortensen, Preben B.; Werge, Thomas M.; Hougaard, David M.; Christiansen, Michael.
In: PLoS ONE, Vol. 13, No. 12, e0208829, 13.12.2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes
AU - Bybjerg-Grauholm, Jonas
AU - Hagen, Christian M.
AU - Gonçalves, Vanessa F.
AU - Bækvad-Hansen, Marie
AU - Hansen, Christine S.
AU - Hedley, Paula L.
AU - Kanters, Jørgen K.
AU - Nielsen, Jimmi
AU - Theisen, Michael
AU - Mors, Ole
AU - Kennedy, James
AU - Als, Thomas D.
AU - Demur, Alfonso B.
AU - Nordentoft, Merete
AU - Børglum, Anders
AU - Mortensen, Preben B.
AU - Werge, Thomas M.
AU - Hougaard, David M.
AU - Christiansen, Michael
PY - 2018/12/13
Y1 - 2018/12/13
N2 - Mitochondrial DNA (mtDNA) haplogroups (hgs) are evolutionarily conserved sets of mtDNA SNP-haplotypes with characteristic geographical distribution. Associations of hgs with disease and physiological characteristics have been reported, but have frequently not been reproducible. Using 418 mtDNA SNPs on the PsychChip (Illumina), we assessed the spatio-temporal distribution of mtDNA hgs in Denmark from DNA isolated from 24,642 geographically un-biased dried blood spots (DBS), collected from 1981 to 2005 through the Danish National Neonatal Screening program. ADMIXTURE was used to establish the genomic ancestry of all samples using a reference of 100K+ autosomal SNPs in 2,248 individuals from nine populations. Median-joining analysis determined that the hgs were highly variable, despite being typically Northern European in origin, suggesting multiple founder events. Furthermore, considerable heterogeneity and variation in nuclear genomic ancestry was observed. Thus, individuals with hg H exhibited 95%, and U hgs 38.2% - 92.5%, Danish ancestry. Significant clines between geographical regions and rural and metropolitan populations were found. Over 25 years, macro-hg L increased from 0.2% to 1.2% (p = 1.1*E-10), and M from 1% to 2.4% (p = 3.7*E-8). Hg U increased among the R macro-hg from 14.1% to 16.5% (p = 1.9*E-3). Genomic ancestry, geographical skewedness, and sub-hg distribution suggested that the L, M and U increases are due to immigration. The complex spatio-temporal dynamics and genomic ancestry of mtDNA in the Danish population reflect repeated migratory events and, in later years, net immigration. Such complexity may explain the often contradictory and population-specific reports of mito-genomic association with disease.
AB - Mitochondrial DNA (mtDNA) haplogroups (hgs) are evolutionarily conserved sets of mtDNA SNP-haplotypes with characteristic geographical distribution. Associations of hgs with disease and physiological characteristics have been reported, but have frequently not been reproducible. Using 418 mtDNA SNPs on the PsychChip (Illumina), we assessed the spatio-temporal distribution of mtDNA hgs in Denmark from DNA isolated from 24,642 geographically un-biased dried blood spots (DBS), collected from 1981 to 2005 through the Danish National Neonatal Screening program. ADMIXTURE was used to establish the genomic ancestry of all samples using a reference of 100K+ autosomal SNPs in 2,248 individuals from nine populations. Median-joining analysis determined that the hgs were highly variable, despite being typically Northern European in origin, suggesting multiple founder events. Furthermore, considerable heterogeneity and variation in nuclear genomic ancestry was observed. Thus, individuals with hg H exhibited 95%, and U hgs 38.2% - 92.5%, Danish ancestry. Significant clines between geographical regions and rural and metropolitan populations were found. Over 25 years, macro-hg L increased from 0.2% to 1.2% (p = 1.1*E-10), and M from 1% to 2.4% (p = 3.7*E-8). Hg U increased among the R macro-hg from 14.1% to 16.5% (p = 1.9*E-3). Genomic ancestry, geographical skewedness, and sub-hg distribution suggested that the L, M and U increases are due to immigration. The complex spatio-temporal dynamics and genomic ancestry of mtDNA in the Danish population reflect repeated migratory events and, in later years, net immigration. Such complexity may explain the often contradictory and population-specific reports of mito-genomic association with disease.
UR - http://www.scopus.com/inward/record.url?scp=85058431802&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0208829
DO - 10.1371/journal.pone.0208829
M3 - Journal article
C2 - 30543675
AN - SCOPUS:85058431802
VL - 13
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 12
M1 - e0208829
ER -
ID: 210385314