TY - JOUR

T1 - Additional targets of the Arabidopsis autonomous pathway members, FCA and FY

AU - Marquardt, Sebastian

AU - Boss, P.K.

AU - Hadfield, J.

AU - Dean, C.

PY - 2006

Y1 - 2006

N2 - A central player in the Arabidopsis floral transition is the floral repressor FLC, the MADS-box transcriptional regulator that inhibits the activity of genes required to switch the meristem from vegetative to floral development. One of the many pathways that regulate FLC expression is the autonomous promotion pathway composed of FCA, FY, FLD, FPA, FVE, LD, and FLK. Rather than a hierarchical set of activities the autonomous promotion pathway comprises sub-pathways of genes with different biochemical functions that all share FLC as a target. One sub-pathway involves FCA and FY, which interact to regulate RNA processing of FLC. Several of the identified components (FY, FVE, and FLD) are homologous to yeast and mammalian proteins with rather generic roles in gene regulation. So why do mutations in these genes specifically show a late-flowering phenotype in Arabidopsis? One reason, found during the analysis of fy alleles, is that the mutant alleles identified in flowering screens can be hypomorphic, they still have partial function. A broader role for the autonomous promotion pathway is supported by a microarray analysis which has identified genes mis-regulated in fca mutants, and whose expression is also altered in fy mutants.

AB - A central player in the Arabidopsis floral transition is the floral repressor FLC, the MADS-box transcriptional regulator that inhibits the activity of genes required to switch the meristem from vegetative to floral development. One of the many pathways that regulate FLC expression is the autonomous promotion pathway composed of FCA, FY, FLD, FPA, FVE, LD, and FLK. Rather than a hierarchical set of activities the autonomous promotion pathway comprises sub-pathways of genes with different biochemical functions that all share FLC as a target. One sub-pathway involves FCA and FY, which interact to regulate RNA processing of FLC. Several of the identified components (FY, FVE, and FLD) are homologous to yeast and mammalian proteins with rather generic roles in gene regulation. So why do mutations in these genes specifically show a late-flowering phenotype in Arabidopsis? One reason, found during the analysis of fy alleles, is that the mutant alleles identified in flowering screens can be hypomorphic, they still have partial function. A broader role for the autonomous promotion pathway is supported by a microarray analysis which has identified genes mis-regulated in fca mutants, and whose expression is also altered in fy mutants.

KW - Alleles

KW - Arabidopsis

KW - Arabidopsis Proteins

KW - Flowers

KW - Gene Expression Regulation, Plant

KW - Models, Genetic

KW - Mutation

KW - Oligonucleotide Array Sequence Analysis

KW - Polyadenylation

KW - RNA Processing, Post-Transcriptional

KW - RNA, Messenger

KW - RNA-Binding Proteins

KW - mRNA Cleavage and Polyadenylation Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1093/jxb/erl073

DO - 10.1093/jxb/erl073

M3 - Review

C2 - 16940039

VL - 57

SP - 3379

EP - 3386

JO - Journal of Experimental Botany. Flowering Newsletter

JF - Journal of Experimental Botany. Flowering Newsletter

SN - 1754-6613

IS - 13

ER -