A non-destructive method for quality control of the pellet distribution within a MUPS tablet by terahertz pulsed imaging
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A non-destructive method for quality control of the pellet distribution within a MUPS tablet by terahertz pulsed imaging. / Novikova, Anna; Markl, Daniel; Axel Zeitler, J; Rades, Thomas; Leopold, Claudia S.
In: European Journal of Pharmaceutical Sciences, Vol. 111, 01.2018, p. 549-555.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A non-destructive method for quality control of the pellet distribution within a MUPS tablet by terahertz pulsed imaging
AU - Novikova, Anna
AU - Markl, Daniel
AU - Axel Zeitler, J
AU - Rades, Thomas
AU - Leopold, Claudia S
N1 - Copyright © 2017. Published by Elsevier B.V.
PY - 2018/1
Y1 - 2018/1
N2 - Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform. Cross-section images of the tablets were extracted at different depths and parallel to the tablet faces from 3D terahertz data to visualize the surface-near structure of the MUPS tablets. The images of the surface-near structure of the MUPS tablets were compared to X-ray microtomography images at the same depths. The surface-near structure could be clearly resolved by TPI at depths between 24 and 152μm below the tablet surface. An increasing amount of pellets within the MUPS tablets appears to slightly decrease the detectability of the pellets within the tablets by TPI. TPI was shown to be a non-destructive method for the detection of pellets within the tablets and could resolve structures thicker than 30μm. In conclusion, a proof-of-concept was provided for TPI as a method of quality control for MUPS tablets.
AB - Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform. Cross-section images of the tablets were extracted at different depths and parallel to the tablet faces from 3D terahertz data to visualize the surface-near structure of the MUPS tablets. The images of the surface-near structure of the MUPS tablets were compared to X-ray microtomography images at the same depths. The surface-near structure could be clearly resolved by TPI at depths between 24 and 152μm below the tablet surface. An increasing amount of pellets within the MUPS tablets appears to slightly decrease the detectability of the pellets within the tablets by TPI. TPI was shown to be a non-destructive method for the detection of pellets within the tablets and could resolve structures thicker than 30μm. In conclusion, a proof-of-concept was provided for TPI as a method of quality control for MUPS tablets.
KW - Journal Article
U2 - 10.1016/j.ejps.2017.10.029
DO - 10.1016/j.ejps.2017.10.029
M3 - Journal article
C2 - 29056403
VL - 111
SP - 549
EP - 555
JO - Norvegica Pharmaceutica Acta
JF - Norvegica Pharmaceutica Acta
SN - 0928-0987
ER -
ID: 185402818