Purpose: The aim of this study was to explore the factor structure of the Danish translation of the eating disorder quality of life scale and evaluate the internal reliability and convergent validity of the scale in a Danish cohort of women with AN. Methods: The total sample comprised 211 patients diagnosed with anorexia nervosa age 13–40 years. Patients completed questionnaires assessing eating disorder psychopathology, physical and social functioning, and well-being. Results: Factor analyses were not able to support the current division of the scale into 12 factors. We found excellent internal consistency of the eating disorder quality-of-life scale total score. We found relevant associations between quality of life and pre-determined variables. Conclusion: This study supports the use of the total score of the eating disorder quality of life scale in assessing quality of life in patients with anorexia nervosa. However, future studies should explore the factor structure of the scale further. Level of evidence: III: Evidence obtained from cohort or case-control analytic studies.