Thermal degradation of amorphous glibenclamide
Research output: Contribution to journal › Journal article › peer-review
A glibenclamide polymorph published by Panagopoulou-Kaplani and Malamataris (2000) , obtained by sublimation of amorphous glibenclamide, was analysed. A new interpretation of the data is presented and experimentally confirmed by X-ray powder diffractometry, Fourier transformation infrared spectroscopy, differential scanning calorimetry, and mass spectrometry. The crystals formed during sublimation of amorphous glibenclamide do not represent a glibenclamide polymorph, but a thermal degradation product, namely 1,3-dicyclohexylurea. The reaction mechanism is suggested to be an elimination of cyclohexylisocyanate from glibenclamide. Cyclohexylisocyanate may decompose to carbon monoxide and cyclohexylamine, which may react in an addition reaction with another cyclohexylisocyanate molecule forming 1,3-dicyclohexylurea.
|Journal||European Journal of Pharmaceutics and Biopharmaceutics|
|Number of pages||6|
|Publication status||Published - Jan 2012|
- 1,3-Dicyclohexylurea, Amorphous, Glibenclamide, Polymorphism, Thermal degradation