The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

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The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. / Hornbak, Malene; Banasik, Karina; Justesen, Johanne Marie; Krarup, Nikolaj Thure; Sandholt, Camilla Helene; Andersson, Åsa; Sandbaek, Annelli; Lauritzen, Torsten; Pisinger, Charlotta; Witte, Daniel R; Sørensen, Thorkild I.A.; Pedersen, Oluf; Hansen, Torben.

In: BMC Medical Genetics, Vol. 12, No. 1, 06.01.2011, p. 4.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hornbak, M, Banasik, K, Justesen, JM, Krarup, NT, Sandholt, CH, Andersson, Å, Sandbaek, A, Lauritzen, T, Pisinger, C, Witte, DR, Sørensen, TIA, Pedersen, O & Hansen, T 2011, 'The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load', BMC Medical Genetics, vol. 12, no. 1, pp. 4. https://doi.org/10.1186/1471-2350-12-4

APA

Hornbak, M., Banasik, K., Justesen, J. M., Krarup, N. T., Sandholt, C. H., Andersson, Å., ... Hansen, T. (2011). The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. BMC Medical Genetics, 12(1), 4. https://doi.org/10.1186/1471-2350-12-4

Vancouver

Hornbak M, Banasik K, Justesen JM, Krarup NT, Sandholt CH, Andersson Å et al. The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. BMC Medical Genetics. 2011 Jan 6;12(1):4. https://doi.org/10.1186/1471-2350-12-4

Author

Hornbak, Malene ; Banasik, Karina ; Justesen, Johanne Marie ; Krarup, Nikolaj Thure ; Sandholt, Camilla Helene ; Andersson, Åsa ; Sandbaek, Annelli ; Lauritzen, Torsten ; Pisinger, Charlotta ; Witte, Daniel R ; Sørensen, Thorkild I.A. ; Pedersen, Oluf ; Hansen, Torben. / The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. In: BMC Medical Genetics. 2011 ; Vol. 12, No. 1. pp. 4.

Bibtex

@article{bc461f9466a94895a9384d57b7d6ac48,
title = "The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load",
abstract = "ABSTRACT: Background A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid beta-oxidation. Chronic exposure to fatty acids due to an impaired beta-oxidation may down-regulate the glucose-stimulated insulin release and result in an increased risk of type 2 diabetes (T2D). We aimed to investigate whether the two variants associate with altered insulin release following an oral glucose load or with T2D. Methods The variants were genotyped using KASPar(R) PCR SNP genotyping system and investigated for associations with estimates of insulin release and insulin sensitivity following an oral glucose tolerance test (OGTT) in a random sample of middle-aged Danish individuals (nACADS=4,324; nACADM=4,337). The T2D-case-control study involved a total of ~8,300 Danish individuals (nACADS=8,313; nACADM=8,344). Results In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS associated with reduced measures of serum insulin at 30 min following an oral glucose load (per allele effect (beta)=-3.8{\%} (-6.3{\%};-1.3{\%}), P=0.003), reduced incremental area under the insulin curve (beta=-3.6{\%} (-6.3{\%};-0.9{\%}), P=0.009), reduced acute insulin response (beta=-2.2{\%} (-4.2{\%};0.2{\%}), P=0.03), and with increased insulin sensitivity ISIMatsuda (beta= 2.9{\%} (0.5{\%};5.2{\%}), P=0.02). The C-allele did not associate with two other measures of insulin sensitivity or with a derived disposition index. The C-allele was not associated with T2D in the case-control analysis (OR 1.07, 95{\%} CI 0.96-1.18, P=0.21). rs11161510 of ACADM did not associate with any indices of glucose-stimulated insulin release or with T2D. Conclusions In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS was associated with reduced measures of glucose-stimulated insulin release during an OGTT, a finding which in part may be mediated through an impaired beta-oxidation of fatty acids.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Malene Hornbak and Karina Banasik and Justesen, {Johanne Marie} and Krarup, {Nikolaj Thure} and Sandholt, {Camilla Helene} and {\AA}sa Andersson and Annelli Sandbaek and Torsten Lauritzen and Charlotta Pisinger and Witte, {Daniel R} and S{\o}rensen, {Thorkild I.A.} and Oluf Pedersen and Torben Hansen",
year = "2011",
month = "1",
day = "6",
doi = "10.1186/1471-2350-12-4",
language = "English",
volume = "12",
pages = "4",
journal = "B M C Medical Genetics",
issn = "1471-2350",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

AU - Hornbak, Malene

AU - Banasik, Karina

AU - Justesen, Johanne Marie

AU - Krarup, Nikolaj Thure

AU - Sandholt, Camilla Helene

AU - Andersson, Åsa

AU - Sandbaek, Annelli

AU - Lauritzen, Torsten

AU - Pisinger, Charlotta

AU - Witte, Daniel R

AU - Sørensen, Thorkild I.A.

AU - Pedersen, Oluf

AU - Hansen, Torben

PY - 2011/1/6

Y1 - 2011/1/6

N2 - ABSTRACT: Background A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid beta-oxidation. Chronic exposure to fatty acids due to an impaired beta-oxidation may down-regulate the glucose-stimulated insulin release and result in an increased risk of type 2 diabetes (T2D). We aimed to investigate whether the two variants associate with altered insulin release following an oral glucose load or with T2D. Methods The variants were genotyped using KASPar(R) PCR SNP genotyping system and investigated for associations with estimates of insulin release and insulin sensitivity following an oral glucose tolerance test (OGTT) in a random sample of middle-aged Danish individuals (nACADS=4,324; nACADM=4,337). The T2D-case-control study involved a total of ~8,300 Danish individuals (nACADS=8,313; nACADM=8,344). Results In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS associated with reduced measures of serum insulin at 30 min following an oral glucose load (per allele effect (beta)=-3.8% (-6.3%;-1.3%), P=0.003), reduced incremental area under the insulin curve (beta=-3.6% (-6.3%;-0.9%), P=0.009), reduced acute insulin response (beta=-2.2% (-4.2%;0.2%), P=0.03), and with increased insulin sensitivity ISIMatsuda (beta= 2.9% (0.5%;5.2%), P=0.02). The C-allele did not associate with two other measures of insulin sensitivity or with a derived disposition index. The C-allele was not associated with T2D in the case-control analysis (OR 1.07, 95% CI 0.96-1.18, P=0.21). rs11161510 of ACADM did not associate with any indices of glucose-stimulated insulin release or with T2D. Conclusions In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS was associated with reduced measures of glucose-stimulated insulin release during an OGTT, a finding which in part may be mediated through an impaired beta-oxidation of fatty acids.

AB - ABSTRACT: Background A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid beta-oxidation. Chronic exposure to fatty acids due to an impaired beta-oxidation may down-regulate the glucose-stimulated insulin release and result in an increased risk of type 2 diabetes (T2D). We aimed to investigate whether the two variants associate with altered insulin release following an oral glucose load or with T2D. Methods The variants were genotyped using KASPar(R) PCR SNP genotyping system and investigated for associations with estimates of insulin release and insulin sensitivity following an oral glucose tolerance test (OGTT) in a random sample of middle-aged Danish individuals (nACADS=4,324; nACADM=4,337). The T2D-case-control study involved a total of ~8,300 Danish individuals (nACADS=8,313; nACADM=8,344). Results In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS associated with reduced measures of serum insulin at 30 min following an oral glucose load (per allele effect (beta)=-3.8% (-6.3%;-1.3%), P=0.003), reduced incremental area under the insulin curve (beta=-3.6% (-6.3%;-0.9%), P=0.009), reduced acute insulin response (beta=-2.2% (-4.2%;0.2%), P=0.03), and with increased insulin sensitivity ISIMatsuda (beta= 2.9% (0.5%;5.2%), P=0.02). The C-allele did not associate with two other measures of insulin sensitivity or with a derived disposition index. The C-allele was not associated with T2D in the case-control analysis (OR 1.07, 95% CI 0.96-1.18, P=0.21). rs11161510 of ACADM did not associate with any indices of glucose-stimulated insulin release or with T2D. Conclusions In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS was associated with reduced measures of glucose-stimulated insulin release during an OGTT, a finding which in part may be mediated through an impaired beta-oxidation of fatty acids.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1186/1471-2350-12-4

DO - 10.1186/1471-2350-12-4

M3 - Journal article

C2 - 21211036

VL - 12

SP - 4

JO - B M C Medical Genetics

JF - B M C Medical Genetics

SN - 1471-2350

IS - 1

ER -

ID: 32325562