The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action
Research output: Contribution to journal › Journal article › Research › peer-review
Glucagon-like peptide 1 (GLP-1) exerts beneficial antidiabetic actions via effects on pancreatic beta- and alpha-cells. Previous studies have focused on the improvements in beta-cell function, while the inhibition of alpha-cell secretion has received less attention. The aim of this research was to quantify the glucagonostatic contribution to the glucose-lowering effect of GLP-1 infusions in patients with type 2 diabetes.
Original language | English |
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Journal | Diabetes |
Volume | 59 |
Issue number | 7 |
Pages (from-to) | 1765-70 |
Number of pages | 6 |
ISSN | 0012-1797 |
DOIs | |
Publication status | Published - 1 Jul 2010 |
- Adult, Analysis of Variance, Area Under Curve, Blood Glucose, Diabetes Mellitus, Type 2, Glucagon, Glucagon-Like Peptide 1, Glucose Clamp Technique, Humans, Insulin, Male, Middle Aged, Time Factors, Treatment Outcome
Research areas
ID: 33940158